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Advances in Brief

Gene Silencing of the Tyrosine Phosphatase SHP1 Gene by Aberrant Methylation in Leukemias/Lymphomas

Takashi Oka, Mamoru Ouchida, Maho Koyama, Yoichiro Ogama, Shinichi Takada, Yoko Nakatani, Takehiro Tanaka, Tadashi Yoshino, Kazuhiko Hayashi, Nobuya Ohara, Eisaku Kondo, Kiyoshi Takahashi, Junjiro Tsuchiyama, Mitsune Tanimoto, Kenji Shimizu and Tadaatsu Akagi
Takashi Oka
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Mamoru Ouchida
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Maho Koyama
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Yoichiro Ogama
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Shinichi Takada
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Yoko Nakatani
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Takehiro Tanaka
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Tadashi Yoshino
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Kazuhiko Hayashi
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Nobuya Ohara
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Eisaku Kondo
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Kiyoshi Takahashi
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Junjiro Tsuchiyama
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Mitsune Tanimoto
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Kenji Shimizu
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Tadaatsu Akagi
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DOI:  Published November 2002
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Abstract

High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.

Footnotes

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

  • ↵1 Supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan (#12670161, #09470051).

  • ↵2 To whom requests for reprints should be addressed, at Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. Phone: 81-86-235-7150; Fax: 81-86-235-7156; E-mail: oka{at}md.okayama-u.ac.jp

  • Received August 2, 2002.
  • Accepted October 4, 2002.
  • ©2002 American Association for Cancer Research.
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Cancer Research: 62 (22)
November 2002
Volume 62, Issue 22
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Gene Silencing of the Tyrosine Phosphatase SHP1 Gene by Aberrant Methylation in Leukemias/Lymphomas
Takashi Oka, Mamoru Ouchida, Maho Koyama, Yoichiro Ogama, Shinichi Takada, Yoko Nakatani, Takehiro Tanaka, Tadashi Yoshino, Kazuhiko Hayashi, Nobuya Ohara, Eisaku Kondo, Kiyoshi Takahashi, Junjiro Tsuchiyama, Mitsune Tanimoto, Kenji Shimizu and Tadaatsu Akagi
Cancer Res November 15 2002 (62) (22) 6390-6394;

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Gene Silencing of the Tyrosine Phosphatase SHP1 Gene by Aberrant Methylation in Leukemias/Lymphomas
Takashi Oka, Mamoru Ouchida, Maho Koyama, Yoichiro Ogama, Shinichi Takada, Yoko Nakatani, Takehiro Tanaka, Tadashi Yoshino, Kazuhiko Hayashi, Nobuya Ohara, Eisaku Kondo, Kiyoshi Takahashi, Junjiro Tsuchiyama, Mitsune Tanimoto, Kenji Shimizu and Tadaatsu Akagi
Cancer Res November 15 2002 (62) (22) 6390-6394;
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