Article Figures & Data
Figures
- Fig. 1.
Immunohistochemical staining of NSCLC tissues with anti-90K 1A4.22 antibody. A strong cytoplasmic reactivity is evident in a squamous cell carcinoma (A) and in an adenocarcinoma (B). Negative immunostaining of a squamous cell carcinoma (C) and an adenocarcinoma (D).
- Fig. 2.
Disease-free (A) and overall survival (B) in the 72 NSCLC patients based on high or low 90K expression
- Fig. 3.
Association between 90K expression evaluated immunohistochemically and protein levels determined by ELISA. Fourteen randomly selected tumors were analyzed by immunohistochemistry and regarded as high or low. The same tumors were assayed for 90K levels by ELISA. The graph shows the quantitative 90K levels of high and low samples. Also indicated are means; bars, ±SD. The difference was statistically significant (P = 0.017).
Tables
- Table 1
90K status in stage I NSCLC tumors according to the clinicopathological features of patients
Variable 90K low n (%) 90K high n (%) P Age (mean± SD, yr) 63.8± 7.1 63.2± 6.3 0.72 Sex Male 50 (96) 17 (85) 0.13 Female 2 (4) 3 (15) Tumor differentiation Well (G1) 14 (27) 6 (30) 0.92 Moderate (G2) 20 (38) 8 (40) Poor (G3) 18 (35) 6 (30) Histological type SCCa 25 (48) 11 (55) 0.90 AD 19 (36) 6 (30) BAC 4 (8) 2 (10) LCC 4 (8) 1 (5) Tumor size T1 12 (23) 7 (35) 0.37 T2 40 (77) 13 (65) Distant metastases Present 11 (21) 12 (60) 0.0038 Absent 41 (79) 8 (40) -
a SCC, squamous cell carcinoma; AD, adenocarcinoma; BAC, bronchioloalveolar carcinoma; and LCC, large cell carcinoma.
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- Table 2
Multivariate analysis of prognostic variables for disease-free and overall survival
Variable Disease-free survival Overall survival β SE HR (95% CI) P β SE HR (95% CI) P Tumor differentiation G1–G2/G3 0.80 0.52 0.45 (1.23–0.16) 0.12 0.78 0.51 0.46 (1.25–0.17) 0.13 Histological type SCCa/non-SCC 0.42 0.42 0.66 (1.50–0.29) 0.32 0.36 0.42 0.70 (1.58–0.31) 0.32 Tumor size T1/T2 0.63 0.51 0.53 (1.46–0.20) 0.22 0.66 0.51 0.52 (1.41–0.19) 0.20 90K expression Low/high 1.70 0.43 5.50 (12.87–2.34) 0.0003 1.62 0.43 5.04 (11.72–2.16) 0.0005 -
a SE, standard error; HR, Hodds ratio; CI, confidence interval; SCC, squamous cell carcinoma.
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Volume 62, Issue 9
