Sensitive methods to detect the earliest forms of colorectal a challenge despite the development of serum and cyclic peptide motif, identified via differential phage converted into a multimodal, high affinity imaging agent colorectal cancer by nuclear imaging and fluorescence cover features the putative structure of the imaging ectopic colon tumors by the radiolabeled agent, and the fluorescent endoscopic detection of orthotopic colon tumors active agent. These results show proof-of-principle that library-derived fluorescent probes can be rapidly developed early detection of cancers by optical means. For details, Kelly et al. on page 6247 of this issue.