The cover shows a molecular classifier for gastric cancer based on the expression levels of three genes in normal gastric mucosa (green frame) gastritis (blue frame), intestinal metaplasia (brown frame) and gastric adenocarcinoma (red frame). The authors describe the construction of molecular classifiers based on trios of genes that can discriminate between malignant and non-malignant samples. Importantly, some samples of in-testinal metaplasia, known to be at higher risk of becoming malignant, showed signatures that resemble that of a tumor sample. For details, see the article by Meireles et al. on p. 1255 of this issue.