Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Epidemiology

Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds

Alison P. Klein, Kieran A. Brune, Gloria M. Petersen, Michael Goggins, Anne C. Tersmette, G. Johan A. Offerhaus, Constance Griffin, John L. Cameron, Charles J. Yeo, Scott Kern and Ralph H. Hruban
Alison P. Klein
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kieran A. Brune
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gloria M. Petersen
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Goggins
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anne C. Tersmette
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Johan A. Offerhaus
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Constance Griffin
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John L. Cameron
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charles J. Yeo
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Scott Kern
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralph H. Hruban
1Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland; 2 Departments of Pathology, 3 Oncology, and 4 Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; 5Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; and 6Department of Pathology, the Academic Medical Center, Amsterdam, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/0008-5472.CAN-03-3823 Published April 2004
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Individuals with a family history of pancreatic cancer have an increased risk of developing pancreatic cancer. Quantification of this risk provides a rational basis for cancer risk counseling and for screening for early pancreatic cancer. In a prospective registry-based study, we estimated the risk of pancreatic cancer in individuals with a family history of pancreatic cancer. Standardized incidence ratios were calculated by comparing the number of incident pancreatic cancers observed with those expected using Surveillance, Epidemiology and End Results (SEER) rates. Familial pancreatic cancer (FPC) kindreds were defined as kindreds having at least one pair of first-degree relatives with pancreatic cancer, and sporadic pancreatic cancer (SPC) kindreds as families without such an affected pair. Nineteen incident pancreatic cancers developed among 5,179 individuals from 838 kindreds (at baseline, 370 FPC kindreds and 468 SPC kindreds). Of these 5,179 individuals, 3,957 had at least one first-degree relative with pancreatic cancer and contributed 10,538 person-years of follow-up. In this group, the observed-to-expected rate of pancreatic cancer was significantly elevated in members of FPC kindreds [9.0; 95% confidence interval (CI), 4.5–16.1], but not in the SPC kindreds (1.8; 95% CI., 0.22–6.4). This risk in FPC kindreds was elevated in individuals with three (32.0; 95% CI, 10.2–74.7), two (6.4; CI, 1.8–16.4), or one (4.6; CI, 0.5–16.4) first-degree relative(s) with pancreatic cancer. Risk was not increased among 369 spouses and other genetically unrelated relatives. Risk was higher in smokers than in nonsmokers. Individuals with a strong family history of pancreatic cancer have a significantly increased risk of developing pancreatic cancer.

  • Received December 11, 2003.
  • Revision received February 2, 2004.
  • Accepted February 4, 2004.
  • ©2004 American Association for Cancer Research.
View Full Text
PreviousNext
Back to top
Cancer Research: 64 (7)
April 2004
Volume 64, Issue 7
  • Table of Contents
  • About the Cover

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
Alison P. Klein, Kieran A. Brune, Gloria M. Petersen, Michael Goggins, Anne C. Tersmette, G. Johan A. Offerhaus, Constance Griffin, John L. Cameron, Charles J. Yeo, Scott Kern and Ralph H. Hruban
Cancer Res April 1 2004 (64) (7) 2634-2638; DOI: 10.1158/0008-5472.CAN-03-3823

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
Alison P. Klein, Kieran A. Brune, Gloria M. Petersen, Michael Goggins, Anne C. Tersmette, G. Johan A. Offerhaus, Constance Griffin, John L. Cameron, Charles J. Yeo, Scott Kern and Ralph H. Hruban
Cancer Res April 1 2004 (64) (7) 2634-2638; DOI: 10.1158/0008-5472.CAN-03-3823
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • INTRODUCTION
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Abstract 4634: Breastfeeding and prognosis of breast cancer among Chinese women
  • Abstract 6483: Performance characteristics of the first FDA-cleared droplet digital PCR (ddPCR) IVD assay for monitoring chronic myelogenous leukemia
  • Abstract 6495: Development of robust and reproducible controls to support clinical implementation of quantitative immunofluorescence assays for pharmacodynamic biomarkers
Show more Epidemiology
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement