Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Endocrinology

Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats

David E. Blask, George C. Brainard, Robert T. Dauchy, John P. Hanifin, Leslie K. Davidson, Jean A. Krause, Leonard A. Sauer, Moises A. Rivera-Bermudez, Margarita L. Dubocovich, Samar A. Jasser, Darin T. Lynch, Mark D. Rollag and Frederick Zalatan
David E. Blask
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
George C. Brainard
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert T. Dauchy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John P. Hanifin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leslie K. Davidson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean A. Krause
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leonard A. Sauer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Moises A. Rivera-Bermudez
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Margarita L. Dubocovich
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Samar A. Jasser
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Darin T. Lynch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark D. Rollag
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frederick Zalatan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/0008-5472.CAN-05-1945 Published December 2005
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The increased breast cancer risk in female night shift workers has been postulated to result from the suppression of pineal melatonin production by exposure to light at night. Exposure of rats bearing rat hepatomas or human breast cancer xenografts to increasing intensities of white fluorescent light during each 12-hour dark phase (0-345 μW/cm2) resulted in a dose-dependent suppression of nocturnal melatonin blood levels and a stimulation of tumor growth and linoleic acid uptake/metabolism to the mitogenic molecule 13-hydroxyoctadecadienoic acid. Venous blood samples were collected from healthy, premenopausal female volunteers during either the daytime, nighttime, or nighttime following 90 minutes of ocular bright, white fluorescent light exposure at 580 μW/cm2 (i.e., 2,800 lx). Compared with tumors perfused with daytime-collected melatonin-deficient blood, human breast cancer xenografts and rat hepatomas perfused in situ, with nocturnal, physiologically melatonin-rich blood collected during the night, exhibited markedly suppressed proliferative activity and linoleic acid uptake/metabolism. Tumors perfused with melatonin-deficient blood collected following ocular exposure to light at night exhibited the daytime pattern of high tumor proliferative activity. These results are the first to show that the tumor growth response to exposure to light during darkness is intensity dependent and that the human nocturnal, circadian melatonin signal not only inhibits human breast cancer growth but that this effect is extinguished by short-term ocular exposure to bright, white light at night. These mechanistic studies are the first to provide a rational biological explanation for the increased breast cancer risk in female night shift workers.

  • melatonin
  • light
  • breast cancer
  • liver cancer
  • circadian rhythm

Footnotes

  • Note: D.E. Blask, G.C. Brainard, R.T. Dauchy, and J.P. Hanifin contributed equally to this work.

  • We dedicate this article to the memory of our colleague and friend, the late Dr. William B. Guiney, Jr.

  • Received June 6, 2005.
  • Revision received September 12, 2005.
  • Accepted September 13, 2005.
  • ©2005 American Association for Cancer Research.
View Full Text
PreviousNext
Back to top
Cancer Research: 65 (23)
December 2005
Volume 65, Issue 23
  • Table of Contents
  • About the Cover

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats
David E. Blask, George C. Brainard, Robert T. Dauchy, John P. Hanifin, Leslie K. Davidson, Jean A. Krause, Leonard A. Sauer, Moises A. Rivera-Bermudez, Margarita L. Dubocovich, Samar A. Jasser, Darin T. Lynch, Mark D. Rollag and Frederick Zalatan
Cancer Res December 1 2005 (65) (23) 11174-11184; DOI: 10.1158/0008-5472.CAN-05-1945

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Melatonin-Depleted Blood from Premenopausal Women Exposed to Light at Night Stimulates Growth of Human Breast Cancer Xenografts in Nude Rats
David E. Blask, George C. Brainard, Robert T. Dauchy, John P. Hanifin, Leslie K. Davidson, Jean A. Krause, Leonard A. Sauer, Moises A. Rivera-Bermudez, Margarita L. Dubocovich, Samar A. Jasser, Darin T. Lynch, Mark D. Rollag and Frederick Zalatan
Cancer Res December 1 2005 (65) (23) 11174-11184; DOI: 10.1158/0008-5472.CAN-05-1945
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Abstract LB-131: Profile of glucose metabolism in bladder cancer patients and the inhibitory effect of sulforaphane on bladder cancer glycolysis by regulating microRNA expression
  • Abstract 6468: Prognostic genomic alterations associated with recurrence after primary therapy for patients with luminal B breast cancer
  • Abstract 6450: Circulating hepsin as a novel serum biomarker in prostate cancer patients
Show more Endocrinology
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement