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Chemistry 6: Natural Products

Inhibition of spontaneous tumorigenicity in transgenic mice by modified citrus pectin

Pratima Nangia-Makker, Allen Saliganan, Larry Tait, Victor Hogan, Judith Abrams and Avraham Raz
Pratima Nangia-Makker
Wayne State University, Detroit, MI
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Allen Saliganan
Wayne State University, Detroit, MI
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Larry Tait
Wayne State University, Detroit, MI
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Victor Hogan
Wayne State University, Detroit, MI
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Judith Abrams
Wayne State University, Detroit, MI
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Avraham Raz
Wayne State University, Detroit, MI
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DOI:  Published May 2005
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Proc Amer Assoc Cancer Res, Volume 46, 2005

Abstract

3071

Citrus pectin (CP) is a complex, highly branched, plant polysaccharide, which contains a backbone consisting of polygalacturonic acid and side chains consisting of pentose and hexose sugars. We have earlier modified citrus pectin into smaller structure by pH and temperature modification and named it MCP. MCP reduced the metastatic spread of mouse melanoma cells B16 F1, prostate cancer cells Mat-LyLu , breast cancer cells MDA-MB-435 and colon cancer cells LSLiM6 in various animal models. We questioned, whether MCP has only therapeutic effects or also preventive effects on tumor formation in mice. Therefore we selected two transgenic mouse model systems, which produce spontaneous tumors. B6.129-Apc tm1Rak mice carry a chain termination mutation in amino acid 1638 (exon 15) of the Apc gene. Mice homozygous to this mutation are embryonically lethal and heterozygous mice develop multiple colonic polyps, gastrointestinal adenomas and adenocarcinomas. The second transgenic mouse model used for prostate and mammary cancer contained a recombinant gene expressing the simian virus 40 early-region transforming sequences under the regulatory control of the rat prostatic steroid binding protein [C3(1)] gene. The female mice develop mammary tumors and the male offsprings develop prostate tumors. The mice were bred in the Wayne State University animal facility and separated after weaning in groups fed on water or MCP. The mammary tumors were studied after 6 months, and prostatic or intestinal tumors were observed after 8 months. Our results indicate that MCP does not have a preventive action on the growth of spontaneous mammary or prostate cancer, but it reduces the number of tumors of the small intestine significantly.

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Cancer Research: 65 (9 Supplement)
May 2005
Volume 65, Issue 9 Supplement
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Inhibition of spontaneous tumorigenicity in transgenic mice by modified citrus pectin
Pratima Nangia-Makker, Allen Saliganan, Larry Tait, Victor Hogan, Judith Abrams and Avraham Raz
Cancer Res May 1 2005 (65) (9 Supplement) 722;

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Inhibition of spontaneous tumorigenicity in transgenic mice by modified citrus pectin
Pratima Nangia-Makker, Allen Saliganan, Larry Tait, Victor Hogan, Judith Abrams and Avraham Raz
Cancer Res May 1 2005 (65) (9 Supplement) 722;
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