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Cancer Research
Cancer Research
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About the Cover

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Cancers are described as wounds that do not heal, suggesting that the two share common features. By comparing microarray data from a model of renal regeneration and repair with reported gene expression in renal cell carcinoma (RCC), Riss et al., found two expression signatures: a predominant concordant signature and a lesser discordant one. The concordant gene signature supports the view of cancer as a wound. The discordant signature, however, points to processes, pathways, and genes that differentiate cancer from wounds. These observations provide a conceptual framework to understand the biology and diagnostic and therapeutic strategies of RCC and acute renal failure. For details, see the article by Riss et al. on page 7216 of this issue.

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Cancer Research: 66 (14)
July 2006
Volume 66, Issue 14
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Issue Highlights

  • Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma
  • The G-quadruplex Ligand Telomestatin Inhibits POT1 Binding to Telomeric Sequences In vitro and Induces GFP-POT1 Dissociation from Telomeres in Human Cells
  • Expression of the FUS-CHOP Fusion Protein in Primary Mesenchymal Progenitor Cells Gives Rise to a Model of Myxoid Liposarcoma
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Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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