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Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells

Maria Y. Wang, Kan V. Lu, Shaojun Zhu, Ederlyn Q. Dia, Igor Vivanco, Gregory M. Shackleford, Webster K. Cavenee, Ingo K. Mellinghoff, Timothy F. Cloughesy, Charles L. Sawyers and Paul S. Mischel
Maria Y. Wang
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Kan V. Lu
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Shaojun Zhu
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Ederlyn Q. Dia
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Igor Vivanco
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Webster K. Cavenee
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Ingo K. Mellinghoff
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Timothy F. Cloughesy
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DOI: 10.1158/0008-5472.CAN-04-4392 Published August 2006
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Article Information

Volume 66, Issue 16, pp. 7864-7869

DOI 
https://doi.org/10.1158/0008-5472.CAN-04-4392
PubMed 
16912159

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received December 9, 2004
  • Revision received June 8, 2006
  • Accepted July 3, 2006
  • Published first August 15, 2006.

Copyright & Usage 
©2006 American Association for Cancer Research.

Author Information

  1. Maria Y. Wang1,8,
  2. Kan V. Lu1,
  3. Shaojun Zhu1,
  4. Ederlyn Q. Dia1,
  5. Igor Vivanco4,
  6. Gregory M. Shackleford7,
  7. Webster K. Cavenee9,
  8. Ingo K. Mellinghoff4,
  9. Timothy F. Cloughesy2,5,
  10. Charles L. Sawyers3,4,6, and
  11. Paul S. Mischel1,5
  1. Departments of 1Pathology and Laboratory Medicine, 2Neurology, 3Medicine, 4Molecular and Medical Pharmacology, 5Henry E. Singleton Brain Tumor Program, and 6Howard Hughes Medical Institute, David Geffen School of Medicine, University of California at Los Angeles; 7Departments of Pediatrics, and Molecular Microbiology and Immunology, Keck School of Medicine at University of Southern California, Los Angeles, California; 8Ventana Medical Systems, Tucson, Arizona; and 9Ludwig Institute for Cancer Research at University of California, San Diego, California
  1. Requests for reprints:
    Paul S. Mischel, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte, Los Angeles, CA 90095-1732. Phone: 310-794-5223; Fax: 310-206-8290; E-mail: pmischel{at}mednet.ucla.edu.
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Cancer Research: 66 (16)
August 2006
Volume 66, Issue 16
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Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells
Maria Y. Wang, Kan V. Lu, Shaojun Zhu, Ederlyn Q. Dia, Igor Vivanco, Gregory M. Shackleford, Webster K. Cavenee, Ingo K. Mellinghoff, Timothy F. Cloughesy, Charles L. Sawyers and Paul S. Mischel
Cancer Res August 15 2006 (66) (16) 7864-7869; DOI: 10.1158/0008-5472.CAN-04-4392

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Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells
Maria Y. Wang, Kan V. Lu, Shaojun Zhu, Ederlyn Q. Dia, Igor Vivanco, Gregory M. Shackleford, Webster K. Cavenee, Ingo K. Mellinghoff, Timothy F. Cloughesy, Charles L. Sawyers and Paul S. Mischel
Cancer Res August 15 2006 (66) (16) 7864-7869; DOI: 10.1158/0008-5472.CAN-04-4392
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