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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines

Samir E. Witta, Robert M. Gemmill, Fred R. Hirsch, Christopher D. Coldren, Karla Hedman, Larisa Ravdel, Barbara Helfrich, Rafal Dziadziuszko, Daniel C. Chan, Michio Sugita, Zeng Chan, Anna Baron, Wilbur Franklin, Harry A. Drabkin, Luc Girard, Adi F. Gazdar, John D. Minna and Paul A. Bunn Jr.
Samir E. Witta
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Robert M. Gemmill
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Fred R. Hirsch
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Christopher D. Coldren
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Karla Hedman
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Larisa Ravdel
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Barbara Helfrich
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Rafal Dziadziuszko
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Daniel C. Chan
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Michio Sugita
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Zeng Chan
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Anna Baron
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Wilbur Franklin
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Harry A. Drabkin
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Luc Girard
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Adi F. Gazdar
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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John D. Minna
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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Paul A. Bunn Jr.
Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
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DOI: 10.1158/0008-5472.CAN-05-1988 Published January 2006
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Article Information

Volume 66, Issue 2, pp. 944-950

DOI 
https://doi.org/10.1158/0008-5472.CAN-05-1988
PubMed 
16424029

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received June 7, 2005
  • Revision received October 24, 2005
  • Accepted November 1, 2005
  • Published first January 19, 2006.

Copyright & Usage 
©2006 American Association for Cancer Research.

Author Information

  1. Samir E. Witta1,
  2. Robert M. Gemmill1,
  3. Fred R. Hirsch1,2,
  4. Christopher D. Coldren1,
  5. Karla Hedman1,
  6. Larisa Ravdel1,
  7. Barbara Helfrich1,
  8. Rafal Dziadziuszko1,4,
  9. Daniel C. Chan1,
  10. Michio Sugita2,
  11. Zeng Chan3,
  12. Anna Baron3,
  13. Wilbur Franklin2,
  14. Harry A. Drabkin1,
  15. Luc Girard5,
  16. Adi F. Gazdar5,
  17. John D. Minna5, and
  18. Paul A. Bunn Jr.1
  1. Departments of 1Medicine/Medical Oncology, 2Pathology, and 3Preventive Medicine and Biometrics, University of Colorado Health Sciences Center and University of Colorado Cancer Center, Aurora, Colorado; 4Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; and 5Hamon Center for Therapeutic Oncology Research, Dallas, Texas
  1. Requests for reprints:
    Samir E. Witta, Department of Medicine/Medical Oncology, University of Colorado Health Sciences Center, Campus Box 8117, P.O. Box 6511, Aurora, CO 80045. Phone: 303-724-3876; Fax: 303-724-3889; E-mail: Samir.Witta{at}uchsc.edu.
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Cancer Research: 66 (2)
January 2006
Volume 66, Issue 2
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Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines
Samir E. Witta, Robert M. Gemmill, Fred R. Hirsch, Christopher D. Coldren, Karla Hedman, Larisa Ravdel, Barbara Helfrich, Rafal Dziadziuszko, Daniel C. Chan, Michio Sugita, Zeng Chan, Anna Baron, Wilbur Franklin, Harry A. Drabkin, Luc Girard, Adi F. Gazdar, John D. Minna and Paul A. Bunn Jr.
Cancer Res January 15 2006 (66) (2) 944-950; DOI: 10.1158/0008-5472.CAN-05-1988

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Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines
Samir E. Witta, Robert M. Gemmill, Fred R. Hirsch, Christopher D. Coldren, Karla Hedman, Larisa Ravdel, Barbara Helfrich, Rafal Dziadziuszko, Daniel C. Chan, Michio Sugita, Zeng Chan, Anna Baron, Wilbur Franklin, Harry A. Drabkin, Luc Girard, Adi F. Gazdar, John D. Minna and Paul A. Bunn Jr.
Cancer Res January 15 2006 (66) (2) 944-950; DOI: 10.1158/0008-5472.CAN-05-1988
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