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Reviews

Melatonin in Cancer Management: Progress and Promise

Brittney Jung and Nihal Ahmad
Brittney Jung
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Nihal Ahmad
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DOI: 10.1158/0008-5472.CAN-06-1776 Published October 2006
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Abstract

Physiologic and pharmacologic concentrations of the pineal hormone melatonin have shown chemopreventive, oncostatic, and tumor inhibitory effects in a variety of in vitro and in vivo experimental models of neoplasia. Multiple mechanisms have been suggested for the biological effects of melatonin. Not only does melatonin seem to control development alone but also has the potential to increase the efficacy and decrease the side effects of chemotherapy when used in adjuvant settings. This review critically evaluates progress in the ability of melatonin to prevent or reverse cancer development and progression. We also discuss future prospects of the possible development of melatonin as a chemopreventive agent. (Cancer Res 2006; 66(20): 9789-93)

  • melatonin
  • cancer

Footnotes

    • Received May 15, 2006.
    • Revision received July 25, 2006.
    • Accepted August 10, 2006.
    • ©2006 American Association for Cancer Research.
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    Cancer Research: 66 (20)
    October 2006
    Volume 66, Issue 20
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    Melatonin in Cancer Management: Progress and Promise
    Brittney Jung and Nihal Ahmad
    Cancer Res October 15 2006 (66) (20) 9789-9793; DOI: 10.1158/0008-5472.CAN-06-1776

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    Melatonin in Cancer Management: Progress and Promise
    Brittney Jung and Nihal Ahmad
    Cancer Res October 15 2006 (66) (20) 9789-9793; DOI: 10.1158/0008-5472.CAN-06-1776
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    • Article
      • Abstract
      • Introduction
      • Mechanism of Action of Melatonin
      • Cancer and Melatonin
      • Preclinical Studies on Melatonin and Cancer
      • Clinical Studies on Melatonin and Cancer
      • Melatonin and Epidemiologic Studies
      • Melatonin in Adjuvant Settings
      • Melatonin in Immunoenhancement
      • Conclusion
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