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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing

Hans K. Erickson, Peter U. Park, Wayne C. Widdison, Yelena V. Kovtun, Lisa M. Garrett, Karen Hoffman, Robert J. Lutz, Victor S. Goldmacher and Walter A. Blättler
Hans K. Erickson
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Peter U. Park
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Lisa M. Garrett
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Robert J. Lutz
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Victor S. Goldmacher
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DOI: 10.1158/0008-5472.CAN-05-4489 Published April 2006
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Cited By

Article Information

Volume 66, Issue 8, pp. 4426-4433

DOI 
https://doi.org/10.1158/0008-5472.CAN-05-4489
PubMed 
16618769

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received December 20, 2005
  • Revision received February 1, 2006
  • Accepted February 13, 2006
  • Published first April 17, 2006.

Copyright & Usage 
©2006 American Association for Cancer Research.

Author Information

  1. Hans K. Erickson,
  2. Peter U. Park,
  3. Wayne C. Widdison,
  4. Yelena V. Kovtun,
  5. Lisa M. Garrett,
  6. Karen Hoffman,
  7. Robert J. Lutz,
  8. Victor S. Goldmacher, and
  9. Walter A. Blättler
  1. ImmunoGen, Inc., Cambridge, Massachusetts
  1. Requests for reprints:
    Hans K. Erickson, ImmunoGen, Inc., 128 Sidney Street, Cambridge, MA 02139. Phone: 617-995-2500; Fax: 617-995-2510; E-mail: hans.erickson{at}immunogen.com.
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Cancer Research: 66 (8)
April 2006
Volume 66, Issue 8
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Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing
Hans K. Erickson, Peter U. Park, Wayne C. Widdison, Yelena V. Kovtun, Lisa M. Garrett, Karen Hoffman, Robert J. Lutz, Victor S. Goldmacher and Walter A. Blättler
Cancer Res April 15 2006 (66) (8) 4426-4433; DOI: 10.1158/0008-5472.CAN-05-4489

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Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing
Hans K. Erickson, Peter U. Park, Wayne C. Widdison, Yelena V. Kovtun, Lisa M. Garrett, Karen Hoffman, Robert J. Lutz, Victor S. Goldmacher and Walter A. Blättler
Cancer Res April 15 2006 (66) (8) 4426-4433; DOI: 10.1158/0008-5472.CAN-05-4489
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