Article Figures & Data
Tables
- Table 1.
Genes up regulated in parous rats
Fold-change G1P1 versus G0P0 Gene name Symbol Gene ID Function Category Lewis WF F344 Cop Median Immunoglobulin heavy chain Igha 314487 Immunoglobulin Immune 39.4 25.4 12.4 6.9 18.9 Casein beta Csn2 29173 Milk protein Differentiation 8.0 5.2 1.6 1.5 3.4 IgM light chain 287965 Immunoglobulin Immune 2.5 3.8 2.0 1.6 2.2 Insulin-like growth factor binding protein 5 Igfbp5 25285 Igf1-binding Growth factor/ECM 2.4 1.4 1.1 2.7 1.9 Casein gamma Csng 114595 Milk protein Differentiation 3.1 1.9 1.8 0.9 1.9 Lipopolysaccharide binding protein Lbp 29469 Antibacterial Immune 2.1 1.3 1.0 2.0 1.7 Matrix metalloproteinase 12 Mmp12 117033 Proteolysis ECM/Immune 2.6 1.4 1.6 1.3 1.5 Carbonic anhydrase 2 Ca2 54231 Carbon metabolism Metabolism 1.5 1.5 1.5 1.1 1.5 Fatty acid synthase Fasn 50671 Fatty acid biosynthesis Metabolism/Differentation 2.0 1.6 1.3 0.9 1.5 Cytochrome P450, family 4, subfamily b,1 Cyp4b1 24307 Monooxygenase activity Metabolism 1.6 1.5 1.4 1.2 1.4 Transforming growth factor, beta 3 Tgfb3 25717 Cell growth/proliferation Tgf-β 1.5 1.3 0.9 1.4 1.4 Thioesterase domain containing 1 Thedc1 64669 Fatty acid biosynthesis Metabolism/Differentation 1.9 1.2 0.8 1.5 1.3 Malic enzyme 1 Me1 24552 Pyruvate synthesis Metabolism 1.3 1.4 1.4 1.1 1.3 Phosphodiesterase 4B Pde4b 24626 cAMP phoshodiesterase Signal transduction 1.3 1.4 0.8 1.4 1.3 Polymeric immunoglobulin receptor Pigr 25046 Trancytosis Immune 1.7 1.4 1.2 1.1 1.3 Kruppel-like factor 9 Klf9 117560 Transcription Factor Signal transduction 1.3 1.4 1.2 1.1 1.3 Matrix metalloproteinase 11 Mmp11 25481 Proteolysis ECM 1.2 1.2 1.2 1.2 1.2 -
NOTE: Genes identified as up-regulated by at least 1.2-fold in three out of four rat strains as a result of parity are reported from highest to lowest median fold-change. Gene names and symbols are reported based on the Rat Genome Database, and Gene ID according to Entrez Gene. Gene functions and categories are based upon GeneOntology.
Abbreviations: WF, Wistar-Furth; F344, Fischer 344; Cop, Copenhagen.
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- Table 2.
Genes down-regulated in parous rats
Fold-change G0P0 versus G1P1 Gene name Symbol Gene ID Function Category Lewis WF F344 Cop Median Periostin Postn 361945 Cell adhesion ECM 1.9 2.1 1.6 2.2 2.0 Amphiregulin Areg 29183 Epidermal growth factor receptor ligand Growth factor 3.5 2.1 1.9 1.9 2.0 Cellular retinoic acid binding protein I Crabp1 25061 Retinoic acid receptor signaling Signal transduction 1.8 2.1 1.3 1.5 1.7 Glycosylation dependent cell adhesion molecule 1 Glycam1 25258 Selectin ligand Differentiation 0.5 2.2 1.3 1.7 1.5 Secreted acidic cysteine rich glycoprotein Sparc 24791 ECM Formation ECM 1.9 1.3 1.1 1.7 1.5 Lumican Lum 81682 Proteoglycan ECM 1.3 1.5 1.5 1.4 1.5 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 Hmgcs2 24450 Cholesterol/ketone body biosynthesis Metabolism 2.9 1.3 1.6 1.0 1.5 Fibronectin 1 Fn1 25661 Integrin signaling ECM 1.4 1.3 1.3 1.6 1.4 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Cited1 64466 Transcription factor Signal transduction 1.4 1.9 1.3 1.3 1.4 Ectonucleotide pyrophosphatase/phosphodiesterase 2 Enpp2 84050 Lysophospholipase Cell motility 1.7 1.4 0.8 1.3 1.4 Insulin-like growth factor 1 Igf1 24482 Cell proliferation/survival Growth factor 1.7 1.2 1.1 1.5 1.3 Sushi-repeat-containing protein Sprx 64316 1.3 1.3 1.1 1.5 1.3 Lectin, galactose binding, soluble 1 Lgals1 56646 Integrin signaling ECM 1.5 1.2 0.8 1.4 1.3 A kinase (PRKA) anchor protein (gravin) 12 Akap12 83425 Scaffolding protein Signal transduction 1.2 1.6 1.2 1.3 1.3 Lectin, galactose binding, soluble 7 Lgals7 29518 Galactose binding 1.1 1.8 1.4 1.2 1.3 Tropomyosin 1, alpha Tpm1 24851 Actin binding 1.1 1.3 1.3 1.3 1.3 Activity and neurotransmitter induced early gene protein 4 Ania4 360341 CAM kinase Kinase 1.5 1.2 1.0 1.3 1.3 Cytosolic cysteine dioxygenase 1 Cdo1 81718 Cysteine metabolism Metabolism 1.5 1.2 0.8 1.3 1.3 Carbonic anhydrase 3 Ca3 54232 Carbon metabolism Metabolism 1.8 1.2 0.8 1.3 1.2 CD74 antigen Cd74 25599 Immune 1.2 1.2 1.3 1.3 1.2 Tubulin, alpha 1 Tuba1 64158 Microtubule component Cell structure 1.5 1.2 0.9 1.2 1.2 Similar to RIKEN cDNA 6330406I15 RGD1307396 360757 1.6 1.2 1.0 1.3 1.2 Collagen, type 1, alpha 1 Col1a1 29393 ECM structural protein ECM 0.9 1.2 1.2 1.6 1.2 Phosphoglycerate kinase 1 Pgk1 24644 Phosphoprotein glycolysis Metabolism 1.6 1.2 0.9 1.2 1.2 Annexin A5 Anxa5 25673 Calcium ion binding 1.6 1.2 0.8 1.2 1.2 Prohibitin Phb 25344 Regulation of cell cycle Signal transduction 1.3 1.2 1.2 1.1 1.2 Valosin-containing protein Vcp 116643 Endoplasmic reticulum protein catabolism 1.2 1.2 1.2 1.2 1.2 Tropomyosin 4 Tpm4 24852 Actin binding 1.1 1.3 1.2 1.2 1.2 Tubulin, beta 5 Tubb5 29214 Microtubule component Cell structure 1.1 1.3 1.2 1.2 1.2 MORF-related gene X Morf412 317413 1.4 1.2 1.0 1.2 1.2 -
NOTE: Genes identified as down-regulated by at least 1.2-fold in three out of four rat strains as a result of parity are reported from highest to lowest median fold-change. Gene names and symbols are reported based on the Rat Genome Database, and Gene ID according to Entrez Gene. Gene functions and categories are based upon GeneOntology.
Abbreviations: WF, Wistar-Furth; F344, Fischer 344; Cop, Copenhagen.
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January 2007
Volume 67, Issue 2
Volume 67, Issue 2
Correction: Pregnancy-Induced Protection against Mammary Tumorigenesis
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