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Is Anticancer Drug Development Heading in the Right Direction?

Trevor W. Hambley
Trevor W. Hambley
School of Chemistry, The University of Sydney, New South Wales, Australia
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DOI: 10.1158/0008-5472.CAN-08-3786 Published February 2009
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    Figure 1.

    The number of new agents for the treatment for cancer approved by the Food and Drug Administration between 1996 and 2007, plotted as 2-year averages [i.e., 1997 = (1996 + 1997)/2]. Taken from http://www.centerwatch.com/patient/drugs/druglist.html.

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February 2009
Volume 69, Issue 4
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Is Anticancer Drug Development Heading in the Right Direction?
Trevor W. Hambley
Cancer Res February 15 2009 (69) (4) 1259-1262; DOI: 10.1158/0008-5472.CAN-08-3786

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Is Anticancer Drug Development Heading in the Right Direction?
Trevor W. Hambley
Cancer Res February 15 2009 (69) (4) 1259-1262; DOI: 10.1158/0008-5472.CAN-08-3786
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  • Article
    • Abstract
    • Background
    • Molecular Targeting
    • Alternative Strategies
    • Conclusions
    • Disclosure of Potential Conflicts of Interest
    • Acknowledgments
    • Footnotes
    • References
    • The Pace of New Drug Approvals Is Too Slow
    • Human Cancers Are Characterized by Numerous Genetic Mutations
    • Solid Tumors Are More Difficult to Treat than Liquid Tumors
    • Monotherapy Will Be Less Effective than Combinations
    • Cells Grown on Plastic Are Not Ideal Models for Complex Human Cancers
    • Drug Selectivity Is a Relative Term
    • Both the Targeted and Unsupervised Approaches Should Be Pursued
    • Drug Distribution, Metabolism, and Uptake Are Critically Important
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  • drug uptake
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Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
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