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Cell, Tumor, and Stem Cell Biology

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

Emmanuelle Charafe-Jauffret, Christophe Ginestier, Flora Iovino, Julien Wicinski, Nathalie Cervera, Pascal Finetti, Min-Hee Hur, Mark E. Diebel, Florence Monville, Julie Dutcher, Marty Brown, Patrice Viens, Luc Xerri, François Bertucci, Giorgio Stassi, Gabriela Dontu, Daniel Birnbaum and Max S. Wicha
Emmanuelle Charafe-Jauffret
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Christophe Ginestier
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Flora Iovino
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Julien Wicinski
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Nathalie Cervera
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Pascal Finetti
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Min-Hee Hur
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Mark E. Diebel
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Florence Monville
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Julie Dutcher
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Marty Brown
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Patrice Viens
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Luc Xerri
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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François Bertucci
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Giorgio Stassi
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Gabriela Dontu
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Daniel Birnbaum
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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Max S. Wicha
1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
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DOI: 10.1158/0008-5472.CAN-08-2741 Published February 2009
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Article Information

Volume 69, Issue 4, pp. 1302-1313

DOI 
https://doi.org/10.1158/0008-5472.CAN-08-2741
PubMed 
19190339

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received July 16, 2008
  • Revision received October 17, 2008
  • Accepted November 11, 2008
  • Published first February 3, 2009.

Article Versions

  • Previous version (February 3, 2009 - 13:35).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2009 American Association for Cancer Research.

Author Information

  1. Emmanuelle Charafe-Jauffret1,
  2. Christophe Ginestier2,
  3. Flora Iovino3,
  4. Julien Wicinski1,
  5. Nathalie Cervera1,
  6. Pascal Finetti1,
  7. Min-Hee Hur4,
  8. Mark E. Diebel2,
  9. Florence Monville1,
  10. Julie Dutcher2,
  11. Marty Brown2,
  12. Patrice Viens1,
  13. Luc Xerri1,
  14. François Bertucci1,
  15. Giorgio Stassi3,
  16. Gabriela Dontu2,
  17. Daniel Birnbaum1, and
  18. Max S. Wicha2
  1. 1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France; 2Comprehensive Cancer Center, Department of Internal Medicine/Oncology, University of Michigan, Ann Arbor, Michigan; 3Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy; and 4Cheil General Hospital, Sungkyunkwan University, Seoul, Republic of Korea
  1. Requests for reprints:
    Max S. Wicha, Department of Internal Medicine/Hematology-Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0015. Phone: 734-647-9923, Fax: 734-647-9480; E-mail: mwicha{at}med.umich.edu.
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February 2009
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Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature
Emmanuelle Charafe-Jauffret, Christophe Ginestier, Flora Iovino, Julien Wicinski, Nathalie Cervera, Pascal Finetti, Min-Hee Hur, Mark E. Diebel, Florence Monville, Julie Dutcher, Marty Brown, Patrice Viens, Luc Xerri, François Bertucci, Giorgio Stassi, Gabriela Dontu, Daniel Birnbaum and Max S. Wicha
Cancer Res February 15 2009 (69) (4) 1302-1313; DOI: 10.1158/0008-5472.CAN-08-2741

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Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature
Emmanuelle Charafe-Jauffret, Christophe Ginestier, Flora Iovino, Julien Wicinski, Nathalie Cervera, Pascal Finetti, Min-Hee Hur, Mark E. Diebel, Florence Monville, Julie Dutcher, Marty Brown, Patrice Viens, Luc Xerri, François Bertucci, Giorgio Stassi, Gabriela Dontu, Daniel Birnbaum and Max S. Wicha
Cancer Res February 15 2009 (69) (4) 1302-1313; DOI: 10.1158/0008-5472.CAN-08-2741
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