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About the Cover

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RG7204 (PLX4032) is a small molecule inhibitor that selectively blocks the activity of oncogenic BRAFV600E kinase. The BRAFV600E mutation is common in several human cancers, with especially high prevalence in melanoma. In the present study, Yang and colleagues describe the effect of RG7204 on tumor cells. RG7204 suppresses ERK activation and cellular proliferation in tumor cells with BRAFV600E but not in cells expressing only wild-type BRAF. Significantly, RG7204 treatment caused partial or complete tumor regressions and improved survival of animals bearing BRAFV600E tumors, demonstrating potent antitumor activity. These preclinical efficacy data generated in several melanoma xenograft models have foreshadowed the clinical results observed in a multi-center Phase I trial that has been enriched with metastatic melanoma patients testing positive for the BRAFV600E mutation. For details, see the article by Yang and colleagues on page 5518 of this issue.

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Cancer Research: 70 (13)
July 2010
Volume 70, Issue 13
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Issue Highlights

  • RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models
  • Selective BRAFV600E Inhibition Enhances T-Cell Recognition of Melanoma without Affecting Lymphocyte Function
  • Increased Immunogenicity of Tumor-Associated Antigen, Mucin 1, Engineered to Express α-Gal Epitopes: A Novel Approach to Immunotherapy in Pancreatic Cancer
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Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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