Correction: Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth

Dose titration of DT in DEREG mice defines functional depletion of Treg. Groups of 10 to 15 DEREG mice were inoculated s.c. with either 3 × 10⁶ EG7 lymphoma (A, C, E, G, and I) or 1 × 10⁶ MC38-OVA^dim colon adenocarcinoma (B, D, F, H, and J) cells. Mice were treated with either PBS (A and B) or DT (1 ng, C and D; 10 ng, E and F; 100 ng. G and H; 1,000 ng, I and J) on day 0 (the day of tumor inoculation). Mice were then monitored for tumor growth every second day as described, and results were recorded as the tumor growth curves (size in cm²) of individual mice in each group. The number of cured mice is indicated in parentheses in each panel.