Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Research
Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Focus on Computer Resources
      • Highly Cited Collection
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Early Career Award
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citations
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Table of Contents

Breaking Advances

  • Breaking Advances
    Highlights from Recent Cancer Literature
    Cancer Res June 1 2011 71 (11) 3733-3734;

Review

  • Review
    Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer
    Zhi Shi, Amit K. Tiwari, Atish S. Patel, Li-Wu Fu and Zhe-Sheng Chen
    Cancer Res June 1 2011 71 (11) 3735-3738; DOI:10.1158/0008-5472.CAN-11-0375

Perspective

  • Perspective
    Evolved Tumor Suppression: Why Are We So Good at Not Getting Cancer?
    James DeGregori
    Cancer Res June 1 2011 71 (11) 3739-3744; DOI:10.1158/0008-5472.CAN-11-0342

Clinical Studies

  • Clinical Studies
    Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma
    Heisoog Kim, Ciprian Catana, Eva-Maria Ratai, Ovidiu C. Andronesi, Dominique L. Jennings, Tracy T. Batchelor, Rakesh K. Jain and A. Gregory Sorensen
    Cancer Res June 1 2011 71 (11) 3745-3752; DOI:10.1158/0008-5472.CAN-10-2991

    Metabolic changes in the tumor and brain tissue during anti-VEGF therapy can serve as imaging biomarkers for predicting treatment response in patients with recurrent malignant glioblastomas.

Integrated Systems and Technologies

  • Integrated Systems and Technologies
    Preclinical Validation of Electrochemotherapy as an Effective Treatment for Brain Tumors
    Birgit Agerholm-Larsen, Helle K. Iversen, Per Ibsen, Jakob M. Moller, Faisal Mahmood, Kurt Svarre Jensen and Julie Gehl
    Cancer Res June 1 2011 71 (11) 3753-3762; DOI:10.1158/0008-5472.CAN-11-0451

    Enhancing drug uptake through the use of a novel electrode technology can achieve high rates of complete response in a rat model of brain cancer.

Microenvironment and Immunology

  • Microenvironment and Immunology
    Chronic Inflammatory IFN-γ Signaling Suppresses Hepatocarcinogenesis in Mice by Sensitizing Hepatocytes for Apoptosis
    Stefan Lüth, Jörg Schrader, Stefan Zander, Antonella Carambia, Juliane Buchkremer, Samuel Huber, Kurt Reifenberg, Ken-Ichi Yamamura, Peter Schirmacher, Ansgar W. Lohse and Johannes Herkel
    Cancer Res June 1 2011 71 (11) 3763-3771; DOI:10.1158/0008-5472.CAN-10-3232

    Findings highlight the central role of interferon-γ in determining cancer-promoting versus cancer-suppressing inflammation.

  • Microenvironment and Immunology
    A Requirement of STAT3 DNA Binding Precludes Th-1 Immunostimulatory Gene Expression by NF-κB in Tumors
    Heehyoung Lee, Jiehui Deng, Hong Xin, Yong Liu, Drew Pardoll and Hua Yu
    Cancer Res June 1 2011 71 (11) 3772-3780; DOI:10.1158/0008-5472.CAN-10-3304

    This study addresses paradoxes concerning the role of STAT3 and NF-κB as pro-oncogenic yet also immunostimulatory to T-cell responses against cancer.

  • Microenvironment and Immunology
    Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
    Julien Laurent, Eveline Faes-van't Hull, Cedric Touvrey, François Kuonen, Qiang Lan, Girieca Lorusso, Marie-Agnès Doucey, Laura Ciarloni, Natsuko Imaizumi, Gian Carlo Alghisi, Ernesta Fagiani, Khalil Zaman, Roger Stupp, Masabumi Shibuya, Jean-François Delaloye, Gerhard Christofori and Curzio Ruegg
    Cancer Res June 1 2011 71 (11) 3781-3791; DOI:10.1158/0008-5472.CAN-10-3684

    Findings reveal a previously unrecognized activity of placental growth factor, a proangiogenic factor that contributes to tumor angiogenesis and progression in many types of cancer.

  • Microenvironment and Immunology | Free Article
    Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis
    Joshua L. Hood, Roman Susana San and Samuel A. Wickline
    Cancer Res June 1 2011 71 (11) 3792-3801; DOI:10.1158/0008-5472.CAN-10-4455

    Preparation of the metastatic niche in lymph nodes relies in part on the ability of a primary tumor to secrete nanovesicles that can remodel the nodal microenvironment and permit its colonization by tumor cells.

Molecular and Cellular Pathobiology

  • Molecular and Cellular Pathobiology
    CD24 Offers a Therapeutic Target for Control of Bladder Cancer Metastasis Based on a Requirement for Lung Colonization
    Jonathan B. Overdevest, Shibu Thomas, Glen Kristiansen, Donna E. Hansel, Steven C. Smith and Dan Theodorescu
    Cancer Res June 1 2011 71 (11) 3802-3811; DOI:10.1158/0008-5472.CAN-11-0519

    Findings offer preclinical proof-of-concept for antibody targeting of a marker of metastatic progression as a potential new adjuvant therapy for clinical investigation.

  • Molecular and Cellular Pathobiology
    An EGFR-ERK-SOX9 Signaling Cascade Links Urothelial Development and Regeneration to Cancer
    Shizhang Ling, Xiaofei Chang, Luciana Schultz, Thomas K. Lee, Alcides Chaux, Luigi Marchionni, George J. Netto, David Sidransky and David M. Berman
    Cancer Res June 1 2011 71 (11) 3812-3821; DOI:10.1158/0008-5472.CAN-10-3072

    Cells undergoing injury turn on EGF ligand production, which induces the developmental transcription factor SOX9 and supports emergence of a migratory, invasive phenotype.

  • Molecular and Cellular Pathobiology
    Epithelial Cell Organization Suppresses Myc Function by Attenuating Myc Expression
    David R. Simpson, Min Yu, Siyuan Zheng, Zhongming Zhao, Senthil K. Muthuswamy and William P. Tansey
    Cancer Res June 1 2011 71 (11) 3822-3830; DOI:10.1158/0008-5472.CAN-10-3782

    This study finds that epithelial cell organization does not pose a barrier to Myc oncogenicity, pointing to roles for tumor suppression mechanisms other than three-dimensional structure in antagonizing Myc during carcinogenesis.

  • Molecular and Cellular Pathobiology
    Bone Marrow Stroma–Secreted Cytokines Protect JAK2V617F-Mutated Cells from the Effects of a JAK2 Inhibitor
    Taghi Manshouri, Zeev Estrov, Alfonso Quintás-Cardama, Jan Burger, Ying Zhang, Ana Livun, Liza Knez, David Harris, Chad J. Creighton, Hagop M. Kantarjian and Srdan Verstovsek
    Cancer Res June 1 2011 71 (11) 3831-3840; DOI:10.1158/0008-5472.CAN-10-4002

    Myeloproliferative neoplasms rely on support from stromal cells in the bone marrow microenvironment that release IL-6, FGF, and CXCL10.

  • Molecular and Cellular Pathobiology
    A Genome-Wide Search for Promoters That Respond to Increased MYCN Reveals Both New Oncogenic and Tumor Suppressor MicroRNAs Associated with Aggressive Neuroblastoma
    Jason M. Shohet, Rajib Ghosh, Cristian Coarfa, Andrew Ludwig, Ashley L. Benham, Zaowen Chen, Danielle M. Patterson, Eveline Barbieri, Pieter Mestdagh, Denae N. Sikorski, Aleksandar Milosavljevic, Eugene S. Kim and Preethi H. Gunaratne
    Cancer Res June 1 2011 71 (11) 3841-3851; DOI:10.1158/0008-5472.CAN-10-4391

    N-Myc activation is associated with direct repression of a microRNA program that is not generally suppressive to neuroblastoma cells, with possible implications for how to better attack this aggressive pediatric cancer.

  • Molecular and Cellular Pathobiology
    The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
    Divya Khaitan, Marcel E. Dinger, Joseph Mazar, Joanna Crawford, Martin A. Smith, John S. Mattick and Ranjan J. Perera
    Cancer Res June 1 2011 71 (11) 3852-3862; DOI:10.1158/0008-5472.CAN-10-4460

    Long noncoding RNAs (lncRNAs) are a rapidly emerging area of cancer research because of their suspected roles in interacting with messenger RNAs, regulatory microRNAs, and proteins and modulating their functions.

  • Molecular and Cellular Pathobiology
    Mutationally Activated BRAFV600E Elicits Papillary Thyroid Cancer in the Adult Mouse
    Roch-Philippe Charles, Gioia Iezza, Elena Amendola, David Dankort and Martin McMahon
    Cancer Res June 1 2011 71 (11) 3863-3871; DOI:10.1158/0008-5472.CAN-10-4463

    Studies of thyroid cancer, the most common endocrine cancer, will benefit from the development of a high-penetrance, genetically- engineered mouse model, which recapitulates key features of the genetics and pathophysiology of the human disease.

  • Molecular and Cellular Pathobiology
    Mild Elevation of Body Temperature Reduces Tumor Interstitial Fluid Pressure and Hypoxia and Enhances Efficacy of Radiotherapy in Murine Tumor Models
    Arindam Sen, Maegan L. Capitano, Joseph A. Spernyak, John T. Schueckler, Seneca Thomas, Anurag K. Singh, Sharon S. Evans, Bonnie L. Hylander and Elizabeth A. Repasky
    Cancer Res June 1 2011 71 (11) 3872-3880; DOI:10.1158/0008-5472.CAN-10-4482

    Preclinical findings show how mild systemic hyperthermia in mice bearing tumors can increase tumor blood flow and improve the efficacy radiation therapy, prompting immediate attention for clinical evaluation.

Prevention and Epidemiology

  • Prevention and Epidemiology
    A Multistage Association Study Identifies a Breast Cancer Genetic Locus at NCOA7
    Kathryn S.P. Higginbotham, Joan P. Breyer, Kevin M. Bradley, Peggy A. Schuyler, W. Dale Plummer Jr., Marcia E. Freudenthal, Amy Trentham-Dietz, Polly A. Newcomb, Melinda E. Sanders, David L. Page, Fritz F. Parl, Kathleen M. Egan, William D. Dupont and Jeffrey R. Smith
    Cancer Res June 1 2011 71 (11) 3881-3888; DOI:10.1158/0008-5472.CAN-10-2653

    A large genetic association study of growth factor signaling and estrogen metabolism defines a variant in an estrogen receptor-binding transcriptional co-activator that may confer a reduced risk of breast cancer.

  • Prevention and Epidemiology
    Physical Activity after Diagnosis and Risk of Prostate Cancer Progression: Data from the Cancer of the Prostate Strategic Urologic Research Endeavor
    Erin L. Richman, Stacey A. Kenfield, Meir J. Stampfer, Alan Paciorek, Peter R. Carroll and June M. Chan
    Cancer Res June 1 2011 71 (11) 3889-3895; DOI:10.1158/0008-5472.CAN-10-3932

    Brisk walking after diagnosis may inhibit or delay prostate cancer progression among men diagnosed with clinically localized prostate cancer.

  • Prevention and Epidemiology
    LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
    Jennifer Permuth-Wey, Donghwa Kim, Ya-Yu Tsai, Hui-Yi Lin, Y. Ann Chen, Jill Barnholtz-Sloan, Michael J. Birrer, Gregory Bloom, Stephen J. Chanock, Zhihua Chen, Daniel W. Cramer, Julie M. Cunningham, Getachew Dagne, Judith Ebbert-Syfrett, David Fenstermacher, Brooke L. Fridley, Montserrat Garcia-Closas, Simon A. Gayther, William Ge, Aleksandra Gentry-Maharaj, Jesus Gonzalez-Bosquet, Ellen L. Goode, Edwin Iversen, Heather Jim, William Kong, John McLaughlin, Usha Menon, Alvaro N.A. Monteiro, Steven A. Narod, Paul D.P. Pharoah, Catherine M. Phelan, Xiaotao Qu, Susan J. Ramus, Harvey Risch, Joellen M. Schildkraut, Honglin Song, Heather Stockwell, Rebecca Sutphen, Kathryn L. Terry, Jonathan Tyrer, Robert A. Vierkant, Nicolas Wentzensen, Johnathan M. Lancaster, Jin Q. Cheng and Thomas A. Sellers
    Cancer Res June 1 2011 71 (11) 3896-3903; DOI:10.1158/0008-5472.CAN-10-4167

    Common inherited variants in miRNA biogenesis genes may be useful to identify high-risk populations and to develop novel cancer diagnostic, prognostic, and therapeutic strategies.

  • Prevention and Epidemiology
    Identification of an Unintended Consequence of Nrf2-Directed Cytoprotection against a Key Tobacco Carcinogen plus a Counteracting Chemopreventive Intervention
    Joseph D. Paonessa, Yi Ding, Kristen L. Randall, Rex Munday, Dayana Argoti, Paul Vouros and Yuesheng Zhang
    Cancer Res June 1 2011 71 (11) 3904-3911; DOI:10.1158/0008-5472.CAN-11-0396

    An important cytoprotective factor is found to sensitize the bladder to a major tobacco carcinogen, but a chemopreventive strategy is suggested to limit this pitfall.

Therapeutics, Targets, and Chemical Biology

  • Therapeutics, Targets, and Chemical Biology
    Combining Histone Deacetylase Inhibitor Vorinostat with Aurora Kinase Inhibitors Enhances Lymphoma Cell Killing with Repression of c-Myc, hTERT, and microRNA Levels
    Leo Kretzner, Anna Scuto, Pamela M. Dino, Claudia M. Kowolik, Jun Wu, Patrick Ventura, Richard Jove, Stephen J. Forman, Yun Yen and Mark H. Kirschbaum
    Cancer Res June 1 2011 71 (11) 3912-3920; DOI:10.1158/0008-5472.CAN-10-2259

    Proof-of-concept and mechanistic findings prompt clinical evaluation for a novel drug combination that could improve cancer treatment.

  • Therapeutics, Targets, and Chemical Biology
    Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State
    Min-Hyung Lee, Mathivanan Jothi, Andrei V. Gudkov and Asoke K. Mal
    Cancer Res June 1 2011 71 (11) 3921-3931; DOI:10.1158/0008-5472.CAN-10-3358

    Results address the longstanding question of how an aggressive childhood cancer might be prompted to undergo terminal differentiation, suggesting new strategies to improve therapy.

  • Therapeutics, Targets, and Chemical Biology
    Erlotinib-Mediated Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress through NOX4
    Kevin P. Orcutt, Arlene D. Parsons, Zita A. Sibenaller, Peter M. Scarbrough, Yueming Zhu, Arya Sobhakumari, Werner W. Wilke, Amanda L. Kalen, Prabhat Goswami, Francis J. Miller Jr., Douglas R. Spitz and Andrean L. Simons
    Cancer Res June 1 2011 71 (11) 3932-3940; DOI:10.1158/0008-5472.CAN-10-3425

    Findings suggest that the cytotoxicity of EGFR kinase inhibitors in cancer cells may be based in large part on induction of oxidative stress via hydrogen peroxide produced by NOX4 signaling.

  • Therapeutics, Targets, and Chemical Biology
    ErbB3 Ablation Impairs PI3K/Akt-Dependent Mammary Tumorigenesis
    Rebecca S. Cook, Joan T. Garrett, Violeta Sánchez, Jamie C. Stanford, Christian Young, Anindita Chakrabarty, Cammie Rinehart, Yixian Zhang, Yaming Wu, Lee Greenberger, Ivan D. Horak and Carlos L. Arteaga
    Cancer Res June 1 2011 71 (11) 3941-3951; DOI:10.1158/0008-5472.CAN-10-3775

    Findings offer preclinical proof-of-concept that ErbB3 disruption may be therapeutically effective in PI3K/Akt-driven breast cancers.

  • Therapeutics, Targets, and Chemical Biology
    Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice
    Krystyna M. Wozniak, Kenichi Nomoto, Rena G. Lapidus, Ying Wu, Valentina Carozzi, Guido Cavaletti, Kazuhiro Hayakawa, Satoru Hosokawa, Murray J. Towle, Bruce A. Littlefield and Barbara S. Slusher
    Cancer Res June 1 2011 71 (11) 3952-3962; DOI:10.1158/0008-5472.CAN-10-4184

    Compared to taxanes and epothilones, the two major classes of antimitotic drugs used in cancer treatment, a new FDA approved antitubulin drug may cause far less debilitating nerve damage in cancer survivors.

  • Therapeutics, Targets, and Chemical Biology
    Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors
    Kim A. Lopez, Aaron M. Tannenbaum, Marcela C. Assanah, Katy Linskey, Jonathan Yun, Alayar Kangarlu, Orlando D. Gil, Peter Canoll and Jeffrey N. Bruce
    Cancer Res June 1 2011 71 (11) 3963-3971; DOI:10.1158/0008-5472.CAN-10-0906

    The findings of this study suggest that chemotherapy may prime later recurrence by decreasing recruitment of normal glial progenitor cells into a brain tumor microenvironment.

  • Therapeutics, Targets, and Chemical Biology
    6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
    Lucy Liu, Sangkil Nam, Yan Tian, Fan Yang, Jun Wu, Yan Wang, Anna Scuto, Panos Polychronopoulos, Prokopios Magiatis, Leandros Skaltsounis and Richard Jove
    Cancer Res June 1 2011 71 (11) 3972-3979; DOI:10.1158/0008-5472.CAN-10-3852

    Inhibitors of the JAK/STAT3 signaling pathway represent a very appealing therapeutic direction because of the central importance of this pathway in tumor cells and the tumor microenvironment in sustaining malignant growth and progression.

Tumor and Stem Cell Biology

  • Tumor and Stem Cell Biology
    Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness
    Jun Hong, Jian Zhou, Junjiang Fu, Tao He, Jun Qin, Li Wang, Lan Liao and Jianming Xu
    Cancer Res June 1 2011 71 (11) 3980-3990; DOI:10.1158/0008-5472.CAN-10-2914

    Ras-activated MAP kinases promote invasion and metastasis by stabililizing a master regulator of epithelial-mesenchymal transition.

  • Tumor and Stem Cell Biology
    Aldehyde Dehydrogenase in Combination with CD133 Defines Angiogenic Ovarian Cancer Stem Cells That Portend Poor Patient Survival
    Ines A. Silva, Shoumei Bai, Karen McLean, Kun Yang, Kent Griffith, Dafydd Thomas, Christophe Ginestier, Carolyn Johnston, Angela Kueck, R. Kevin Reynolds, Max S. Wicha and Ronald J. Buckanovich
    Cancer Res June 1 2011 71 (11) 3991-4001; DOI:10.1158/0008-5472.CAN-10-3175

    This report identifies a pair of ovarian cancer stem cell markers that may be functionally critical for stem cell differentiation in cancers.

  • Tumor and Stem Cell Biology
    Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer
    Sandra A. O'Toole, Dorothy A. Machalek, Robert F. Shearer, Ewan K.A. Millar, Radhika Nair, Peter Schofield, Duncan McLeod, Caroline L. Cooper, Catriona M. McNeil, Andrea McFarland, Akira Nguyen, Christopher J. Ormandy, Min Ru Qiu, Brian Rabinovich, Luciano G. Martelotto, Duc Vu, Gregory E. Hannigan, Elizabeth A. Musgrove, Daniel Christ, Robert L. Sutherland, D. Neil Watkins and Alexander Swarbrick
    Cancer Res June 1 2011 71 (11) 4002-4014; DOI:10.1158/0008-5472.CAN-10-3738

    This study identifies an important prognostic role of Hedgehog pathway in breast cancer and highlights its potential as a novel therapeutic target in metastatic carcinoma.

  • Tumor and Stem Cell Biology
    The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
    Mei Yee Koh, Robert Lemos Jr, Xiuping Liu and Garth Powis
    Cancer Res June 1 2011 71 (11) 4015-4027; DOI:10.1158/0008-5472.CAN-10-4142

    This study shows how tumor cells exposed to more intense periods of hypoxia in the microenvironment will respond to improve their likelihood of survival and progression, with implications for therapeutic targeting.

  • Tumor and Stem Cell Biology
    EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes β-Catenin–Dependent Hepatocarcinogenesis
    Alfred S.L. Cheng, Suki S. Lau, Yangchao Chen, Yutaka Kondo, May S. Li, Hai Feng, Arthur K. Ching, Kin F. Cheung, Hoi K. Wong, Joanna H. Tong, Hongchuan Jin, Kwong W. Choy, Jun Yu, Ka F. To, Nathalie Wong, Tim H.-M. Huang and Joseph J.Y. Sung
    Cancer Res June 1 2011 71 (11) 4028-4039; DOI:10.1158/0008-5472.CAN-10-3342

    Mechanistic results reveal how the prometastatic transcription repressor EZH2 coordinately blocks Wnt antagonists, thereby promoting Wnt/β-catenin signaling in cancer.

  • Tumor and Stem Cell Biology
    Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
    Nathan P. Young, Denise Crowley and Tyler Jacks
    Cancer Res June 1 2011 71 (11) 4040-4047; DOI:10.1158/0008-5472.CAN-10-4563

    Altering the sequence of mutations in a mouse model of sarcomagenesis shows that mutation order dictates tumor phenotype.

Corrections

  • Corrections
    Correction: Peptide Vaccination after T-Cell Transfer Causes Massive Clonal Expansion, Tumor Eradication, and Manageable Cytokine Storm
    Cancer Res June 1 2011 71 (11) 4048-4048; DOI:10.1158/0008-5472.CAN-11-1279

  • Corrections
    Correction: FLT3-Mediated p38–MAPK Activation Participates in the Control of Megakaryopoiesis in Primary Myelofibrosis
    Cancer Res June 1 2011 71 (11) 4049-4050; DOI:10.1158/0008-5472.CAN-11-1334

  • Corrections
    Correction: Functional Cooperation of RKTG with p53 in Tumorigenesis and Epithelial-Mesenchymal Transition
    Cancer Res June 1 2011 71 (11) 4051-4051; DOI:10.1158/0008-5472.CAN-11-1303

Back to top
PreviousNext
Cancer Research: 71 (11)
June 2011
Volume 71, Issue 11
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover

Sign up for alerts

Issue Highlights

  • Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis
  • EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes β-Catenin–Dependent Hepatocarcinogenesis
  • Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors

Jump to

  • Breaking Advances
  • Review
  • Perspective
  • Clinical Studies
  • Integrated Systems and Technologies
  • Microenvironment and Immunology
  • Molecular and Cellular Pathobiology
  • Prevention and Epidemiology
  • Therapeutics, Targets, and Chemical Biology
  • Tumor and Stem Cell Biology
  • Corrections
Advertisement
  • Most Cited
  • Most Read
Loading
  • Towards Multidrug Adaptive Therapy
  • MEK Inhibition Synergizes with Statins for Cancer Treatment
  • IL1β Promotes Immune Suppression in Pancreatic Cancer
  • Multiple Primary Cancer Penetrance for TP53
  • Metabolomic Gradients in Glioblastoma Models
More...
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement