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Cancer Research
Cancer Research
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About the Cover

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Breast cancer stem cells are regulated by mesenchymal stem cells via cytokine networks. Breast cancer cells secrete IL6, which recruits bone marrow–derived mesenchymal stem cells and induces CXCL7 secretion by these cells. CXCL7 in turn induces the production of multiple cytokines including IL8 and IL6, which completes a positive feedback loop and stimulates the self-renewal of breast cancer stem cells driving tumor growth and metastasis. For details, see the article by Liu and colleagues on page 614 of this issue.

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Cancer Research: 71 (2)
January 2011
Volume 71, Issue 2
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Issue Highlights

  • Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks
  • IL-6 Trans-Signaling in Formation and Progression of Malignant Ascites in Ovarian Cancer
  • The BH3 Mimetic ABT-737 Induces Cancer Cell Senescence
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Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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