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Table of Contents

Breaking Advances

  • Breaking Advances
    Highlights from Recent Cancer Literature
    Cancer Res March 1 2011 71 (5) 1509-1510;

Reviews

  • Reviews
    Ironing Out Cancer
    Suzy V. Torti and Frank M. Torti
    Cancer Res March 1 2011 71 (5) 1511-1514; DOI:10.1158/0008-5472.CAN-10-3614

  • Reviews
    p95HER2 and Breast Cancer
    Joaquín Arribas, José Baselga, Kim Pedersen and Josep Lluís Parra-Palau
    Cancer Res March 1 2011 71 (5) 1515-1519; DOI:10.1158/0008-5472.CAN-10-3795

Priority Reports

  • Priority Reports
    Anti-DLL4 Inhibits Growth and Reduces Tumor-Initiating Cell Frequency in Colorectal Tumors with Oncogenic KRAS Mutations
    Marcus Fischer, Wan-Ching Yen, Ann M. Kapoun, Min Wang, Gilbert O'Young, John Lewicki, Austin Gurney and Timothy Hoey
    Cancer Res March 1 2011 71 (5) 1520-1525; DOI:10.1158/0008-5472.CAN-10-2817

    Findings provide a preclinical rationale for clinical targeting of a Notch receptor ligand to improve treatment of colon cancers with oncogenic KRAS mutations, which are refractory to existing treatments.

  • Priority Reports
    Detection of Circulating Tumor Cells in Human Peripheral Blood Using Surface-Enhanced Raman Scattering Nanoparticles
    Xu Wang, Ximei Qian, Jonathan J. Beitler, Zhuo Georgia Chen, Fadlo R. Khuri, Melinda M. Lewis, Hyung Ju C. Shin, Shuming Nie and Dong M. Shin
    Cancer Res March 1 2011 71 (5) 1526-1532; DOI:10.1158/0008-5472.CAN-10-3069

    This study reports a rapid, simple and inexpensive assay to detect cancer cells in blood, offering a potentially important tool for clinical management of cancer and cancer relapse.

  • Priority Reports
    A Germline Variant in the Interferon Regulatory Factor 4 Gene as a Novel Skin Cancer Risk Locus
    Jiali Han, Abrar A. Qureshi, Hongmei Nan, Jiangwen Zhang, Yiqing Song, Qun Guo and David J. Hunter
    Cancer Res March 1 2011 71 (5) 1533-1539; DOI:10.1158/0008-5472.CAN-10-1818

    A single nucleotide polymorphism identified in a key immune regulatory transcription factor associates with elevated risk of the most common types of skin cancer.

Microenvironment and Immunology

  • Microenvironment and Immunology | Free Article
    Increased Efficacy of Breast Cancer Chemotherapy in Thrombocytopenic Mice
    Mélanie Demers, Benoit Ho-Tin-Noé, Daphne Schatzberg, Janie J. Yang and Denisa D. Wagner
    Cancer Res March 1 2011 71 (5) 1540-1549; DOI:10.1158/0008-5472.CAN-10-2038

    Depleting platelets in tumor-bearing mice preferentially increases the leakiness of the tumor vasculature, leveraging the efficacy of administered chemotherapies without worsening toxic side-effects.

  • Microenvironment and Immunology
    Gap Junction–Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells
    Philip K. Lim, Sarah A. Bliss, Shyam A. Patel, Marcelo Taborga, Meneka A. Dave, Larissa A. Gregory, Steven J. Greco, Margarette Bryan, Prem S. Patel and Pranela Rameshwar
    Cancer Res March 1 2011 71 (5) 1550-1560; DOI:10.1158/0008-5472.CAN-10-2372

    Cellular exchange of microRNAs is emerging as a fascinating new mechanism by which tumor stromal cells can influence the tumor cell pathophysiology

  • Microenvironment and Immunology
    LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution
    Holly E. Barker, Joan Chang, Thomas R. Cox, Georgina Lang, Demelza Bird, Monica Nicolau, Holly R. Evans, Alison Gartland and Janine T. Erler
    Cancer Res March 1 2011 71 (5) 1561-1572; DOI:10.1158/0008-5472.CAN-10-2868

    Findings offer preclinical evidence that breast cancer metastasis can be blocked by targeting an important oxidase in the tumor microenvironment.

  • Microenvironment and Immunology
    Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors
    Beverly L. Falcon, Sharon Barr, Prafulla C. Gokhale, Jeyling Chou, Jennifer Fogarty, Philippe Depeille, Mark Miglarese, David M. Epstein and Donald M. McDonald
    Cancer Res March 1 2011 71 (5) 1573-1583; DOI:10.1158/0008-5472.CAN-10-3126

    Small molecule inhibitors now in clinical development to block both mTORC kinases can leverage the anti-angiogenic actions of VEGF inhibitors.

  • Microenvironment and Immunology
    Stromal Deletion of the APC Tumor Suppressor in Mice Triggers Development of Endometrial Cancer
    Pradeep S. Tanwar, LiHua Zhang, Drucilla J. Roberts and Jose M. Teixeira
    Cancer Res March 1 2011 71 (5) 1584-1596; DOI:10.1158/0008-5472.CAN-10-3166

    This interesting mouse model study suggests that tumor suppressor alterations in stromal tissue may be sufficient to drive progression of some types of cancer

  • Microenvironment and Immunology
    Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing
    Loredana Cifaldi, Elisa Lo Monaco, Matteo Forloni, Ezio Giorda, Silvia Lorenzi, Stefania Petrini, Elisa Tremante, Daniela Pende, Franco Locatelli, Patrizio Giacomini and Doriana Fruci
    Cancer Res March 1 2011 71 (5) 1597-1606; DOI:10.1158/0008-5472.CAN-10-3326

    Findings highlight a novel immunotherapeutic target that is tractable for small molecule inhibition and that could be broadly relevant to many types of human cancer.

  • Microenvironment and Immunology
    TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer
    Bruno Salaun, Laurence Zitvogel, Carine Asselin-Paturel, Yannis Morel, Karine Chemin, Clarisse Dubois, Catherine Massacrier, Rosa Conforti, Marie Pierre Chenard, Jean-Christophe Sabourin, Aicha Goubar, Serge Lebecque, Michel Pierres, Donata Rimoldi, Pedro Romero and Fabrice Andre
    Cancer Res March 1 2011 71 (5) 1607-1614; DOI:10.1158/0008-5472.CAN-10-3490

    Toll receptors that control innate immune response are not only expressed by immune cells but also by many human cancer cells, which might be targeted directly by Toll receptor agonists in certain disease settings.

  • Microenvironment and Immunology
    Novel Role for STAT3 in Transcriptional Regulation of NK Immune Cell Targeting Receptor MICA on Cancer Cells
    Romain Bedel, Antoine Thiery-Vuillemin, Camille Grandclement, Jeremy Balland, Jean-Paul Remy-Martin, Bernadette Kantelip, Jean-René Pallandre, Xavier Pivot, Christophe Ferrand, Pierre Tiberghien and Christophe Borg
    Cancer Res March 1 2011 71 (5) 1615-1626; DOI:10.1158/0008-5472.CAN-09-4540

    Findings reveal a novel mechanism by which STAT3 modulates immunosurveillance by NK immune cells, by repressing the expression of a key NK cell recognition molecule on cancer cells.

  • Microenvironment and Immunology
    Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APCΔ468 Mice
    Eric C. Cheon, Khashayarsha Khazaie, Mohammad W. Khan, Matthew J. Strouch, Seth B. Krantz, Joseph Phillips, Nichole R. Blatner, Laura M. Hix, Ming Zhang, Kristen L. Dennis, Mohammed R. Salabat, Michael Heiferman, Paul J. Grippo, Hidayatullah G. Munshi, Elias Gounaris and David J. Bentrem
    Cancer Res March 1 2011 71 (5) 1627-1636; DOI:10.1158/0008-5472.CAN-10-1923

    “Findings suggest that the established role of arachadonic acid biosynthesis in colon tumorigenesis may be driven to a large degree from mast cells that support myeloid- derived suppressor cells, an important component of the tumor microenvironment thought to drive immune escape.”

  • Microenvironment and Immunology
    Peroxiredoxin 1 Controls Prostate Cancer Growth through Toll-Like Receptor 4–Dependent Regulation of Tumor Vasculature
    Jonah R. Riddell, Wiam Bshara, Michael T. Moser, Joseph A. Spernyak, Barbara A. Foster and Sandra O. Gollnick
    Cancer Res March 1 2011 71 (5) 1637-1646; DOI:10.1158/0008-5472.CAN-10-3674

    This study defines a tumor-derived inducer of inflammation that provides an important mechanistic link between chronic inflammation and prostate carcinogenesis.

Molecular and Cellular Pathobiology

  • Molecular and Cellular Pathobiology
    The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
    Floriane Pez, Frédéric Dayan, Jérome Durivault, Bastien Kaniewski, Géraldine Aimond, Gabrielle S. Le Provost, Blandine Deux, Philippe Clézardin, Pascal Sommer, Jacques Pouysségur and Caroline Reynaud
    Cancer Res March 1 2011 71 (5) 1647-1657; DOI:10.1158/0008-5472.CAN-10-1516

    Findings reveal a regulatory cycle that can act synergistically to favor cancer cell proliferation in hypoxic tumor microenvironments.

  • Molecular and Cellular Pathobiology
    The Role of Calcium in the Activation of Estrogen Receptor-Alpha
    Shailaja D. Divekar, Geoffrey B. Storchan, Katherine Sperle, David J. Veselik, Earl Johnson, Sivanesan Dakshanamurthy, Yuse N. Lajiminmuhip, Rebecca E. Nakles, Li Huang and Mary Beth Martin
    Cancer Res March 1 2011 71 (5) 1658-1668; DOI:10.1158/0008-5472.CAN-10-1899

    Results shed light on a potentially important mechanism involved in estrogen mimicry at the estrogen receptor-alpha, with implications for understanding breast cancer risk and the development of novel therapeutics for treatment of endocrine independent breast cancer.

  • Molecular and Cellular Pathobiology
    Ulcerative Colitis–Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation
    Rosa Ana Risques, Lisa A. Lai, Cigdem Himmetoglu, Anoosheh Ebaee, Lin Li, Ziding Feng, Mary P. Bronner, Bassel Al-Lahham, Kris V. Kowdley, Keith D. Lindor, Peter S. Rabinovitch and Teresa A. Brentnall
    Cancer Res March 1 2011 71 (5) 1669-1679; DOI:10.1158/0008-5472.CAN-10-1966

    In patients with ulcerative coliitis, cell senescence acts as a tumor suppressor mechanism that is abrogated during the transition from low-grade to high-grade dysplasia.

  • Molecular and Cellular Pathobiology
    MicroRNAs miR-199a-5p and -3p Target the Brm Subunit of SWI/SNF to Generate a Double-Negative Feedback Loop in a Variety of Human Cancers
    Kouhei Sakurai, Chihiro Furukawa, Takeshi Haraguchi, Ken-ichi Inada, Kazuya Shiogama, Takanobu Tagawa, Shuji Fujita, Yoshihito Ueno, Aya Ogata, Mai Ito, Yutaka Tsutsumi and Hideo Iba
    Cancer Res March 1 2011 71 (5) 1680-1689; DOI:10.1158/0008-5472.CAN-10-2345

    Findings describe an microRNA-based mechanism constituting a double feedback loop for control of a pivotal chromatin remodeling factor in cancer cells.

  • Molecular and Cellular Pathobiology
    Cyclin D1 Inhibits Mitochondrial Activity in B Cells
    Guergana Tchakarska, Mikel Roussel, Xavier Troussard and Brigitte Sola
    Cancer Res March 1 2011 71 (5) 1690-1699; DOI:10.1158/0008-5472.CAN-10-2564

    Results identify a new function of cyclin D1 that could help explain its important pathophysiological roles in lymphomas and solid tumors.

  • Molecular and Cellular Pathobiology
    Select Heterozygous Keap1 Mutations Have a Dominant-Negative Effect on Wild-Type Keap1 In Vivo
    Takafumi Suzuki, Jonathan Maher and Masayuki Yamamoto
    Cancer Res March 1 2011 71 (5) 1700-1709; DOI:10.1158/0008-5472.CAN-10-2939

    “A single-hit mutation in Keap1, a key regulator of the important cytoprotective gene Nrf2, is sufficient to generate a selective advantage in the cancer microenvironment.”

  • Molecular and Cellular Pathobiology
    Cancer Causes Cardiac Atrophy and Autophagy in a Sexually Dimorphic Manner
    Pippa F. Cosper and Leslie A. Leinwand
    Cancer Res March 1 2011 71 (5) 1710-1720; DOI:10.1158/0008-5472.CAN-10-3145

    Findings reveal the mechanisms of cancer-induced cardiac atrophy, which are distinct from skeletal muscle and exhibit sex differences.

  • Molecular and Cellular Pathobiology
    Rho Kinase Phosphorylation Promotes Ezrin-Mediated Metastasis in Hepatocellular Carcinoma
    Yong Chen, Dongmei Wang, Zhen Guo, Jun Zhao, Bing Wu, Hui Deng, Ti Zhou, Hongjun Xiang, Fei Gao, Xue Yu, Jian Liao, Tarsha Ward, Peng Xia, Chibuzo Emenari, Xia Ding, Winston Thompson, Kelong Ma, Jingde Zhu, Felix Aikhionbare, Kefen Dou, Shi-Yuan Cheng and Xuebiao Yao
    Cancer Res March 1 2011 71 (5) 1721-1729; DOI:10.1158/0008-5472.CAN-09-4683

    This study reveals an important mechanistic linkage in metastasis of liver cancers, with potential therapeutic implications.

  • Molecular and Cellular Pathobiology
    An EGFR–Src–Arg–Cortactin Pathway Mediates Functional Maturation of Invadopodia and Breast Cancer Cell Invasion
    Christopher C. Mader, Matthew Oser, Marco A. O. Magalhaes, Jose Javier Bravo-Cordero, John Condeelis, Anthony J. Koleske and Hava Gil-Henn
    Cancer Res March 1 2011 71 (5) 1730-1741; DOI:10.1158/0008-5472.CAN-10-1432

    Findings define an Abl-related tyrosine kinase in a mechanism of breast cancer invasion that is mediated by invadopodia maturation and function.

  • Molecular and Cellular Pathobiology
    Steroid Receptor Coactivator-1 Upregulates Integrin α5 Expression to Promote Breast Cancer Cell Adhesion and Migration
    Li Qin, Xian Chen, Yelin Wu, Zhen Feng, Tao He, Li Wang, Lan Liao and Jianming Xu
    Cancer Res March 1 2011 71 (5) 1742-1751; DOI:10.1158/0008-5472.CAN-10-3453

    Findings suggest a mechanism through which a transcriptional coactivator can promote invasive progression in breast cancers, where it has been implicated as a marker of poor prognosis.

  • Molecular and Cellular Pathobiology
    Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer
    Tao Zuo, Ta-Ming Liu, Xun Lan, Yu-I Weng, Rulong Shen, Fei Gu, Yi-Wen Huang, Sandya Liyanarachchi, Daniel E. Deatherage, Pei-Yin Hsu, Cenny Taslim, Bhuvaneswari Ramaswamy, Charles L. Shapiro, Huey-Jen L. Lin, Alfred S. L. Cheng, Victor X. Jin and Tim H.-M. Huang
    Cancer Res March 1 2011 71 (5) 1752-1762; DOI:10.1158/0008-5472.CAN-10-3573

    Combination therapy targeting PI3K/AKT signaling and DNA methylation can effectively reactivate epigenetically silenced genes and slow tumor progression.

Prevention and Epidemiology

  • Prevention and Epidemiology
    Long-term Use of Cholesterol-Lowering Drugs and Cancer Incidence in a Large United States Cohort
    Eric J. Jacobs, Christina C. Newton, Michael J. Thun and Susan M. Gapstur
    Cancer Res March 1 2011 71 (5) 1763-1771; DOI:10.1158/0008-5472.CAN-10-2953

    In this large prospective study, long-term use of cholesterol-lowering drugs was associated with lower risk of melanoma, endometrial cancer, and non-Hodgkin lymphoma.

Therapeutics, Targets, and Chemical Biology

  • Therapeutics, Targets, and Chemical Biology
    Using a Stem Cell–Based Signature to Guide Therapeutic Selection in Cancer
    Igor Shats, Michael L. Gatza, Jeffrey T. Chang, Seiichi Mori, Jialiang Wang, Jeremy Rich and Joseph R. Nevins
    Cancer Res March 1 2011 71 (5) 1772-1780; DOI:10.1158/0008-5472.CAN-10-1735

    Findings suggest strategies for therapeutic targeting of a stem-like phenotype in a relevant cohort of cancer patients.

  • Therapeutics, Targets, and Chemical Biology
    Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity
    Shinjiro Nagai, Kazumasa Takenaka, Deepa Nachagari, Charles Rose, Kali Domoney, Daxi Sun, Alex Sparreboom and John D. Schuetz
    Cancer Res March 1 2011 71 (5) 1781-1791; DOI:10.1158/0008-5472.CAN-10-1919

    Findings show how an cellular efflux transporter can circumvent a major pathway to activate therapeutic nucleoside mimetic drugs.

  • Therapeutics, Targets, and Chemical Biology
    Activation of TYRO3/AXL Tyrosine Kinase Receptors in Thyroid Cancer
    Elvira Avilla, Valentina Guarino, Carla Visciano, Federica Liotti, Maria Svelto, GnanaPrakasam Krishnamoorthy, Renato Franco and Rosa Marina Melillo
    Cancer Res March 1 2011 71 (5) 1792-1804; DOI:10.1158/0008-5472.CAN-10-2186

    Findings prompt clinical study of a tractable therapy for thyroid cancer based on disruption of a functionally critical cell surface receptor signaling complex

  • Therapeutics, Targets, and Chemical Biology
    Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors
    Munitta Muthana, Athina Giannoudis, Simon D. Scott, Hsin-Yu Fang, Seth B. Coffelt, Fiona J. Morrow, Craig Murdoch, Julian Burton, Neil Cross, Bernard Burke, Roshna Mistry, Freddie Hamdy, Nicola J. Brown, Lindsay Georgopoulos, Peter Hoskin, Magnus Essand, Claire E. Lewis and Norman J. Maitland
    Cancer Res March 1 2011 71 (5) 1805-1815; DOI:10.1158/0008-5472.CAN-10-2349

    Findings describe the use of macrophages to target an oncolytic adenovirus to hypoxic areas of prostate tumors, to improve viral inhibition of primary and secondary tumour growth.

  • Therapeutics, Targets, and Chemical Biology
    Discovery of DNA Repair Inhibitors by Combinatorial Library Profiling
    Benjamin J. Moeller, Richard L. Sidman, Renata Pasqualini and Wadih Arap
    Cancer Res March 1 2011 71 (5) 1816-1824; DOI:10.1158/0008-5472.CAN-10-2361

    Combinatorial profiling of double-strand DNA break repair machinery yields peptides capable of modulating DNA repair phenotypes and sensitizing tumor cells to genotoxic therapy.

  • Therapeutics, Targets, and Chemical Biology
    CNT1 Expression Influences Proliferation and Chemosensitivity in Drug-Resistant Pancreatic Cancer Cells
    Yangzom D. Bhutia, Sau Wai Hung, Bhavi Patel, Dylan Lovin and Rajgopal Govindarajan
    Cancer Res March 1 2011 71 (5) 1825-1835; DOI:10.1158/0008-5472.CAN-10-2736

    Findings suggest an effective strategy to defeat chemoresistance in human pancreatic cancers, which remains a primary clinical challenge.

  • Therapeutics, Targets, and Chemical Biology
    Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair–Deficient Cancers
    Sarah A. Martin, Madeleine Hewish, David Sims, Christopher J. Lord and Alan Ashworth
    Cancer Res March 1 2011 71 (5) 1836-1848; DOI:10.1158/0008-5472.CAN-10-2836

    A kinase originally linked to Parkinson's disease may offer a potential therapeutic target in treatment of cancers characterized by a specific deficiency in DNA repair.

  • Therapeutics, Targets, and Chemical Biology
    Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases
    Bruce W. Konicek, Jennifer R. Stephens, Ann M. McNulty, Nathaniel Robichaud, Robert B. Peery, Chad A. Dumstorf, Michele S. Dowless, Philip W. Iversen, Stephen Parsons, Karen E. Ellis, Denis J. McCann, Jerry Pelletier, Luc Furic, Jonathan M. Yingling, Louis F. Stancato, Nahum Sonenberg and Jeremy R. Graff
    Cancer Res March 1 2011 71 (5) 1849-1857; DOI:10.1158/0008-5472.CAN-10-3298

    Findings offer initial preclinical proof-of-concept for small molecule blockade of a important translational regulator as a tractable cancer therapeutic approach.

  • Therapeutics, Targets, and Chemical Biology
    Chromosomal Instability Confers Intrinsic Multidrug Resistance
    Alvin J.X. Lee, David Endesfelder, Andrew J. Rowan, Axel Walther, Nicolai J. Birkbak, P. Andrew Futreal, Julian Downward, Zoltan Szallasi, Ian P.M. Tomlinson, Michael Howell, Maik Kschischo and Charles Swanton
    Cancer Res March 1 2011 71 (5) 1858-1870; DOI:10.1158/0008-5472.CAN-10-3604

    Determining the chromosome instability (CIN) status of patient tumors may provide useful information on the clinical response to many cytotoxic agents and small molecules.

  • Therapeutics, Targets, and Chemical Biology | Free Article
    Trastuzumab Has Preferential Activity against Breast Cancers Driven by HER2 Homodimers
    Ritwik Ghosh, Archana Narasanna, Shizhen Emily Wang, Shuying Liu, Anindita Chakrabarty, Justin M. Balko, Ana María González-Angulo, Gordon B. Mills, Elicia Penuel, John Winslow, Jeff Sperinde, Rajiv Dua, Sailaja Pidaparthi, Ali Mukherjee, Kim Leitzel, Wolfgang J. Kostler, Allan Lipton, Michael Bates and Carlos L. Arteaga
    Cancer Res March 1 2011 71 (5) 1871-1882; DOI:10.1158/0008-5472.CAN-10-1872

    Findings suggest that the dimeric state of an oncogenic receptor in cancer cells may impact their therapeutic response to anti-receptor antibodies.

  • Therapeutics, Targets, and Chemical Biology
    Distinct TRAIL Resistance Mechanisms Can Be Overcome by Proteasome Inhibition but not Generally by Synergizing Agents
    Christina Menke, Lianghua Bin, Jacqueline Thorburn, Kian Behbakht, Heide L. Ford and Andrew Thorburn
    Cancer Res March 1 2011 71 (5) 1883-1892; DOI:10.1158/0008-5472.CAN-10-2252

    This study rationalizes anticancer combinations that not only synergize but also overcome drug resistance, a primary challenge in cancer care.

  • Therapeutics, Targets, and Chemical Biology
    Functional Activation of the Estrogen Receptor-α and Aromatase by the HDAC Inhibitor Entinostat Sensitizes ER-Negative Tumors to Letrozole
    Gauri J. Sabnis, Olga Goloubeva, Saranya Chumsri, Nguyen Nguyen, Saraswati Sukumar and Angela M.H. Brodie
    Cancer Res March 1 2011 71 (5) 1893-1903; DOI:10.1158/0008-5472.CAN-10-2458

    This incisive and important preclinical study shows how using histone deacetylase inhibtors to restore ER expression in ER-negative tumors can be used to sensitize them to the therapeutic effects of aromatase inhibitors.

  • Therapeutics, Targets, and Chemical Biology
    6-Thioguanine Reactivates Epigenetically Silenced Genes in Acute Lymphoblastic Leukemia Cells by Facilitating Proteasome-mediated Degradation of DNMT1
    Bifeng Yuan, Jing Zhang, Hongxia Wang, Lei Xiong, Qian Cai, Tina Wang, Steven Jacobsen, Sriharsa Pradhan and Yinsheng Wang
    Cancer Res March 1 2011 71 (5) 1904-1911; DOI:10.1158/0008-5472.CAN-10-3430

    “This study reveals a vital mechanistic connection between the widely employed cancer drug 6-thioguanine and its effects on DNA hypomethylation, with implications for understanding therapeutic efficacy.”

Tumor and Stem Cell Biology

  • Tumor and Stem Cell Biology
    The Epithelial-Mesenchymal Transition Mediator S100A4 Maintains Cancer-Initiating Cells in Head and Neck Cancers
    Jeng-Fan Lo, Cheng-Chia Yu, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Shu-Chun Lin, Chung-Ji Liu, Wen-Yuan Hu and Yau-Hua Yu
    Cancer Res March 1 2011 71 (5) 1912-1923; DOI:10.1158/0008-5472.CAN-10-2350

    A calcium-binding molecule that is prognostic in several cancers is found to be critical to maintain stemness properties, with implications for new cancer targeting strategies.

  • Tumor and Stem Cell Biology
    Prediction and Genetic Demonstration of a Role for Activator E2Fs in Myc-Induced Tumors
    Kenichiro Fujiwara, Inez Yuwanita, Daniel P. Hollern and Eran R. Andrechek
    Cancer Res March 1 2011 71 (5) 1924-1932; DOI:10.1158/0008-5472.CAN-10-2386

    This study establishes the root causal relationships between Myc and E2F, two key transcription factors involved in virtually all human cancers.

  • Tumor and Stem Cell Biology
    The ΔNp63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer
    Niamh E. Buckley, Susan J. Conlon, Karin Jirstrom, Elaine W. Kay, Nyree T. Crawford, Anthony O'Grady, Katherine Sheehan, Simon S. Mc Dade, Ching-Wei Wang, Dennis J. McCance, Patrick G. Johnston, Richard D. Kennedy, D. Paul Harkin and Paul B. Mullan
    Cancer Res March 1 2011 71 (5) 1933-1944; DOI:10.1158/0008-5472.CAN-10-2717

    Findings define an important transcriptional target of BRCA1 that may provide insight into the pathogenesis of basal-like breast cancers, an aggressive but poorly understood disease.

  • Tumor and Stem Cell Biology
    Ron Kinase Transphosphorylation Sustains MET Oncogene Addiction
    Silvia Benvenuti, Luca Lazzari, Addolorata Arnesano, Giulia Li Chiavi, Alessandra Gentile and Paolo M. Comoglio
    Cancer Res March 1 2011 71 (5) 1945-1955; DOI:10.1158/0008-5472.CAN-10-2100

    Insights into how oncogenic addiction is maintained to the MET kinase, which drives a powerful program of invasive growth in cancer cells, suggests strategies to strengthen cancer therapies based on MET inhibition.

  • Tumor and Stem Cell Biology
    Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells
    Päivi Östling, Suvi-Katri Leivonen, Anna Aakula, Pekka Kohonen, Rami Mäkelä, Zandra Hagman, Anders Edsjö, Sara Kangaspeska, Henrik Edgren, Daniel Nicorici, Anders Bjartell, Yvonne Ceder, Merja Perälä and Olli Kallioniemi
    Cancer Res March 1 2011 71 (5) 1956-1967; DOI:10.1158/0008-5472.CAN-10-2421

    A comprehensive survery defines a set of microRNAs that are important regulators of androgen receptor levels and prostate cancer cell proliferation.

  • Tumor and Stem Cell Biology
    Identification of N-Terminally Truncated Stable Nuclear Isoforms of CDC25B That Are Specifically Involved in G2/M Checkpoint Recovery
    Denis Jullien, Beatrix Bugler, Christine Dozier, Martine Cazales and Bernard Ducommun
    Cancer Res March 1 2011 71 (5) 1968-1977; DOI:10.1158/0008-5472.CAN-10-2453

    Findings prompt a rethinking of CDC25B regulation and function and how its impaired expression in cancer may affect susceptibility and chemotherapeutic response.

  • Tumor and Stem Cell Biology
    Identification of a Clinically Relevant Androgen-Dependent Gene Signature in Prostate Cancer
    Hannelore V. Heemers, Lucy J. Schmidt, Zhifu Sun, Kevin M. Regan, S. Keith Anderson, Kelly Duncan, Dan Wang, Song Liu, Karla V. Ballman and Donald J. Tindall
    Cancer Res March 1 2011 71 (5) 1978-1988; DOI:10.1158/0008-5472.CAN-10-2512

    Findings prompt new insights into how androgen signaling might be selectively blocked in prostate cancer cells while sparing normal androgen-dependent processes.

  • Tumor and Stem Cell Biology
    LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases β1 Integrin-Mediated Cell Adhesion and Liver Metastasis
    Rich Y.C. Hsu, Carlos H.F. Chan, Jonathan D. Spicer, Mathieu C. Rousseau, Betty Giannias, Simon Rousseau and Lorenzo E. Ferri
    Cancer Res March 1 2011 71 (5) 1989-1998; DOI:10.1158/0008-5472.CAN-10-2833

    Infectious complications during colon cancer surgery may contribute to liver metastasis, suggesting benefits to inhibiting these complications during the peri-operative period.

  • Tumor and Stem Cell Biology
    High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors
    Stuart A. Rushworth, Kristian M. Bowles and David J. MacEwan
    Cancer Res March 1 2011 71 (5) 1999-2009; DOI:10.1158/0008-5472.CAN-10-3018

    Findings suggest a strategy to render AML cells sensitive to proteosome inhibitory drugs, which are presently ineffective in this disease.

  • Tumor and Stem Cell Biology
    Negative Regulation of the Hippo Pathway by E3 Ubiquitin Ligase ITCH Is Sufficient to Promote Tumorigenicity
    Zaidoun Salah, Gerry Melino and Rami I. Aqeilan
    Cancer Res March 1 2011 71 (5) 2010-2020; DOI:10.1158/0008-5472.CAN-10-3516

    A key regulator of the Hippo tumor suppressor pathway functions as a potent oncogene

Corrections

  • Corrections
    Correction: Antitumoral Immune Response by Recruitment and Expansion of Dendritic Cells in Tumors Infected with Telomerase-Dependent Oncolytic Viruses
    Cancer Res March 1 2011 71 (5) 2021-2021; DOI:10.1158/0008-5472.CAN-11-0067

  • Corrections
    Correction: Serum microRNA Profiles Serve as Novel Biomarkers for HBV Infection and Diagnosis of HBV-Positive Hepatocarcinoma
    Cancer Res March 1 2011 71 (5) 2022-2022; DOI:10.1158/0008-5472.CAN-11-0110

  • Corrections
    Correction: TGF-β-RI Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases
    Cancer Res March 1 2011 71 (5) 2023-2023; DOI:10.1158/0008-5472.CAN-11-0011

  • Corrections
    Correction: Physical Oncology: A Bench-to-Bedside Quantitative and Predictive Approach
    Cancer Res March 1 2011 71 (5) 2024-2024; DOI:10.1158/0008-5472.CAN-11-0122

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Cancer Research: 71 (5)
March 2011
Volume 71, Issue 5
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  • Increased Efficacy of Breast Cancer Chemotherapy in Thrombocytopenic Mice
  • Ron Kinase Transphosphorylation Sustains MET Oncogene Addiction
  • Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APCΔ468 Mice

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Cancer Research Online ISSN: 1538-7445
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