Breaking Advances
Cancer Res April 15 2011 71 (8) 2807-2808;
Table of Contents
Breaking Advances
Reviews
- ReviewsAnn M. Bode and Zigang DongCancer Res April 15 2011 71 (8) 2809-2814; DOI:10.1158/0008-5472.CAN-10-3756
- ReviewsJessica L. Yecies and Brendan D. ManningCancer Res April 15 2011 71 (8) 2815-2820; DOI:10.1158/0008-5472.CAN-10-4158
Priority Report
- Priority ReportTingting Gu, Zhong Zhang, Jianli Wang, Junyi Guo, Wen Hong Shen and Yuxin YinCancer Res April 15 2011 71 (8) 2821-2825; DOI:10.1158/0008-5472.CAN-10-3399
This study offers important insights into the function of the PTEN phosphatase in the nucleus, where this important tumor suppressor appears to act to suppress cancer in addition to its well-described roles in the cytoplasm.
Integrated Systems and Technologies
- Integrated Systems and Technologies | Free ArticleMarkus R. Owen, I. Johanna Stamper, Munitta Muthana, Giles W. Richardson, Jon Dobson, Claire E. Lewis and Helen M. ByrneCancer Res April 15 2011 71 (8) 2826-2837; DOI:10.1158/0008-5472.CAN-10-2834
This study uses multiscale mathematical modeling to study how hypoxic tumor cells can be attacked most effectively, using a proposed cell-based therapy that takes advantage of several targeting principles.
- Integrated Systems and Technologies | Free ArticleRainer K. Sachs, Kerstin Johnsson, Philip Hahnfeldt, Janet Luo, Allen Chen and Lynn HlatkyCancer Res April 15 2011 71 (8) 2838-2847; DOI:10.1158/0008-5472.CAN-10-4600
A comprehensive mechanistic mathematical model gives evidence that the main driving mechanism for CML blast crisis origination is interaction between leukemic and normal cells.
Microenvironment and Immunology
- Microenvironment and ImmunologyDezheng Dong, Christopher Stapleton, Biquan Luo, Shigang Xiong, Wei Ye, Yi Zhang, Niyati Jhaveri, Genyuan Zhu, Risheng Ye, Zhi Liu, Kevin W. Bruhn, Noah Craft, Susan Groshen, Florence M. Hofman and Amy S. LeeCancer Res April 15 2011 71 (8) 2848-2857; DOI:10.1158/0008-5472.CAN-10-3151
Endothelial cell specific knockout illustrates a critical role for a stress chaperone in the tumor microenvironment, extending its known role in tumor cells and deepening its significance to therapeutic and imaging applications.
- Microenvironment and ImmunologyIn Duk Jung, Soo Kyung Jeong, Chang-Min Lee, Kyung Tae Noh, Deok Rim Heo, Yong Kyoo Shin, Cheol-Heui Yun, Won-Jung Koh, Shizuo Akira, Jake Whang, Hwa-Jung Kim, Won Sun Park, Sung Jae Shin and Yeong-Min ParkCancer Res April 15 2011 71 (8) 2858-2870; DOI:10.1158/0008-5472.CAN-10-3487
This study offers a clear rationale for the development of a powerful new vaccine adjuvant for dendritic cell-based immunotherapies, an emerging area of cancer therapy with the first FDA-approved product appearing in 2010.
- Microenvironment and ImmunologyJames C. Lee, Erik Hayman, Hollie J. Pegram, Elmer Santos, Glenn Heller, Michel Sadelain and Renier BrentjensCancer Res April 15 2011 71 (8) 2871-2881; DOI:10.1158/0008-5472.CAN-10-0552
Successful application of adoptive therapy of cancer using autologous T cells genetically targeted to tumor associated antigens is dependent upon prior depletion of tumor infiltrating regulatory T cells.
- Microenvironment and ImmunologyXiaolin Hu, Dafeng Yang, Mary Zimmerman, Feiyan Liu, Jine Yang, Swati Kannan, Andreas Burchert, Zdzislaw Szulc, Alicja Bielawska, Keiko Ozato, Kapil Bhalla and Kebin LiuCancer Res April 15 2011 71 (8) 2882-2891; DOI:10.1158/0008-5472.CAN-10-2493
Findings define how a critical tumor suppressor gene becomes attenuated in chronic myeloid leukemia, and how this attenuation leads to apoptotic resistance and disease progression.
- Microenvironment and ImmunologyJohn Stagg, Upulie Divisekera, Helene Duret, Tim Sparwasser, Michele W.L. Teng, Phillip K. Darcy and Mark J. SmythCancer Res April 15 2011 71 (8) 2892-2900; DOI:10.1158/0008-5472.CAN-10-4246
Findings offer preclinical proof-of-concept for therapeutic targeting of a important cell surface-based driver of immune escape in cancer, perhaps involved in many types of human cancer.
Molecular and Cellular Pathobiology
- Molecular and Cellular PathobiologyChristophe Desterke, Chrystele Bilhou-Nabéra, Bernadette Guerton, Christophe Martinaud, Carole Tonetti, Denis Clay, Paola Guglielmelli, Alessandro Vannucchi, Dominique Bordessoule, Hans Hasselbalch, Brigitte Dupriez, Nassima Benzoubir, Marie-Françoise Bourgeade, Olivier Pierre-Louis, Vladimir Lazar, William Vainchenker, Annelise Bennaceur-Griscelli, Heinz Gisslinger, Stéphane Giraudier and Marie-Caroline Le Bousse-KerdilèsCancer Res April 15 2011 71 (8) 2901-2915; DOI:10.1158/0008-5472.CAN-10-1731
Findings advance understanding of the pathophysiology of primary myelofibrosis, a bone marrow–derived disease, and suggest applications for drugs that target a key megakaryocytic signaling pathway as a new strategy to evaluate for treating this disease.
- Molecular and Cellular PathobiologyXuyu Yang, Nicholas C. Popescu and Drazen B. ZimonjicCancer Res April 15 2011 71 (8) 2916-2925; DOI:10.1158/0008-5472.CAN-10-2158
Findings reveal a mechanism through which plasminogen activator-dependent conversion of plasminogen to plasmin is attenuated, reducing tumor cell capacity for invasion and metastasis in the tumor microenvironment.
- Molecular and Cellular PathobiologyWei Shi, Kate Gerster, Nehad M. Alajez, Jasmine Tsang, Levi Waldron, Melania Pintilie, Angela B. Hui, Jenna Sykes, Christine P'ng, Naomi Miller, David McCready, Anthony Fyles and Fei-Fei LiuCancer Res April 15 2011 71 (8) 2926-2937; DOI:10.1158/0008-5472.CAN-10-3369
This study establishes a novel nodal oncomiR in breast cancer that acts through several pathways to promote metastatic tumor progression.
- Molecular and Cellular PathobiologyPeng Huang, Satoshi Kishida, Dongliang Cao, Yuko Murakami-Tonami, Ping Mu, Masato Nakaguro, Naoshi Koide, Ichiro Takeuchi, Akira Onishi and Kenji KadomatsuCancer Res April 15 2011 71 (8) 2938-2948; DOI:10.1158/0008-5472.CAN-10-3524
Findings establish the critical role of a neuronal differentiation factor in neuroblastoma and its functional relationship with a neuronal repellent factor.
- Molecular and Cellular PathobiologyGrace Wing-Yan Mak, Mandy Man-Lok Chan, Veronica Yee-Law Leong, Joyce Man-Fong Lee, Tai-On Yau, Irene Oi-Lin Ng and Yick-Pang ChingCancer Res April 15 2011 71 (8) 2949-2958; DOI:10.1158/0008-5472.CAN-10-4046
A gene implicated in cancer progression proves to directly support metastasis by activating a PAK kinase implicated in invasive cell motility.
- Molecular and Cellular PathobiologyYuhui Jiang, Xiaoduo Xie, Zhigang Li, Zheng Wang, Yixuan Zhang, Zhiqiang Ling, Yi Pan, Zhenzhen Wang and Yan ChenCancer Res April 15 2011 71 (8) 2959-2968; DOI:10.1158/0008-5472.CAN-10-4077
A novel tumor suppressor collaborates with p53 in tumor formation and epithelial-mesenchymal transition.
- Molecular and Cellular PathobiologyXin-Hai Pei, Feng Bai, Zhijun Li, Matthew D. Smith, Gabrielle Whitewolf, Ran Jin and Yue XiongCancer Res April 15 2011 71 (8) 2969-2977; DOI:10.1158/0008-5472.CAN-10-4300
This study identifies a potential p53 activating E3 ligase located in the cytoplasm that functions as a tumor suppressor.
- Molecular and Cellular PathobiologyJianhui Guo, Li Zheng, Wenyong Liu, Xianshu Wang, Zemin Wang, Zehua Wang, Amy J. French, Dongchon Kang, Lin Chen, Stephen N. Thibodeau and Wanguo LiuCancer Res April 15 2011 71 (8) 2978-2987; DOI:10.1158/0008-5472.CAN-10-3482
A class of mutations that lead to mitochondrial DNA depletion and apoptotic resistance may be important drivers of tumorigenesis in most microsatellite-unstable colorectal cancers.
- Molecular and Cellular PathobiologyVictoria K. Hill, Christopher Ricketts, Ivan Bieche, Sophie Vacher, Dean Gentle, Cheryl Lewis, Eamonn R. Maher and Farida LatifCancer Res April 15 2011 71 (8) 2988-2999; DOI:10.1158/0008-5472.CAN-10-4026
A genome-wide study of DNA methylation patterns suggests clinically useful theranostic markers in breast cancer, as well as new candidate pathways in etiology, progression, and therapy.
Prevention and Epidemiology
- Prevention and EpidemiologyHai-De Qin, Yin Yao Shugart, Jin-Xin Bei, Qing-Hua Pan, Lina Chen, Qi-Sheng Feng, Li-Zhen Chen, Wei Huang, Jian Jun Liu, Timothy J. Jorgensen, Yi-Xin Zeng and Wei-Hua JiaCancer Res April 15 2011 71 (8) 3000-3008; DOI:10.1158/0008-5472.CAN-10-0469
Findings support the notion that RAD51L1 and other DNA repair genes play a role in the etilogy and development of nasopharyngeal carcinoma.
- Prevention and EpidemiologyS.M. Jamshedur Rahman, Adriana L. Gonzalez, Ming Li, Erin H. Seeley, Lisa J. Zimmerman, Xueqiong J. Zhang, M. Lisa Manier, Sandra J. Olson, Ronak N. Shah, Alison N. Miller, Joe B. Putnam, York E. Miller, Wilbur A. Franklin, William J. Blot, David P. Carbone, Yu Shyr, Richard M. Caprioli and Pierre P. MassionCancer Res April 15 2011 71 (8) 3009-3017; DOI:10.1158/0008-5472.CAN-10-2510
This study reports a simple proteomic signature in bronchial specimens as a quantitative tool for the diagnostic assessment of lung cancer beyond qualitative histology methods.
Therapeutics, Targets, and Chemical Biology
- Therapeutics, Targets, and Chemical BiologyTaher Nassar, Suha Attili-Qadri, Oshrat Harush-Frenkel, Shimon Farber, Shimon Lecht, Philip Lazarovici and Simon BenitaCancer Res April 15 2011 71 (8) 3018-3028; DOI:10.1158/0008-5472.CAN-10-3118
An oral nanocarrier of docetaxel favors lymphatic uptake in preclinical studies, potentially stimulating clinical studies that could allow docetaxel chemotherapy to be switched from intravenous to oral delivery in patients.
- Therapeutics, Targets, and Chemical BiologyZhi Shi, Amit K. Tiwari, Suneet Shukla, Robert W. Robey, Satyakam Singh, In-Wha Kim, Susan E. Bates, Xingxiang Peng, Ioana Abraham, Suresh V. Ambudkar, Tanaji T. Talele, Li-Wu Fu and Zhe-Sheng ChenCancer Res April 15 2011 71 (8) 3029-3041; DOI:10.1158/0008-5472.CAN-10-3820
A drug used widely to treat erectile dysfunction in men is found to abrogate two common mechanisms of chemotherapeutic drug resistance, with immediate potential applications to improve the treatment of many advanced cancers.
- Therapeutics, Targets, and Chemical BiologyMichael A. Milhollen, Usha Narayanan, Teresa A. Soucy, Petter O. Veiby, Peter G. Smith and Benjamin AmidonCancer Res April 15 2011 71 (8) 3042-3051; DOI:10.1158/0008-5472.CAN-10-2122
DNA re-replication elicited in cancer cells by a small molecule inhibitor currently in Phase I trials creates an unrecoverable cellular insult, with implications for gaining deeper understanding of a unique therapeutic mechanism of cytotoxicity in cancer treatment.
- Therapeutics, Targets, and Chemical BiologyKatharine Ellwood-Yen, Heike Keilhack, Kaiko Kunii, Brian Dolinski, Yamicia Connor, Kun Hu, Kumiko Nagashima, Erin O'Hare, Yusuf Erkul, Alessandra Di Bacco, Diana Gargano, Nirah H. Shomer, Minilik Angagaw, Erica Leccese, Paula Andrade, Melissa Hurd, Myung K. Shin, Thomas F. Vogt, Alan Northrup, Ekaterina V. Bobkova, Shailaja Kasibhatla, Roderick T. Bronson, Martin L. Scott, Giulio Draetta, Victoria Richon, Nancy Kohl, Peter Blume-Jensen, Jannik N. Andersen and Manfred KrausCancer Res April 15 2011 71 (8) 3052-3065; DOI:10.1158/0008-5472.CAN-10-2282
This study employed a novel RNAi approach useful for context-dependent target validation in vivo, applying it to demonstrate that the protein kinase PDK1 is not a rate limiting factor for PI3K-pathway activation or tumor formation in PTEN-deficient mouse models.
Tumor and Stem Cell Biology
- Tumor and Stem Cell BiologyXun Jin, Hee-Young Jeon, Kyeung Min Joo, Jun-Kyum Kim, Juyoun Jin, Sung Hak Kim, Bong Gu Kang, Samuel Beck, Se Jeong Lee, Joong Kyu Kim, Ae-Kyung Park, Woong-Yang Park, Yun-Jaie Choi, Do-Hyun Nam and Hyunggee KimCancer Res April 15 2011 71 (8) 3066-3075; DOI:10.1158/0008-5472.CAN-10-1495
Findings define an important role in glioma recurrence and poor prognosis for a G-protein coupled receptor that is part of the Wnt signaling family governing stemness and invasiveness of glioma stem cells.
- Tumor and Stem Cell BiologyYuanyuan Qiao, Xia Jiang, Shuet Theng Lee, R.K. Murthy Karuturi, Shing Chuan Hooi and Qiang YuCancer Res April 15 2011 71 (8) 3076-3086; DOI:10.1158/0008-5472.CAN-10-2787
Findings identify a member of the FOXO family of transcription factors as a critical regulator of EMT, stem cell properties, and chemotherapeutic resistance in cancer cells.
- Tumor and Stem Cell BiologyCarmen S. Tellez, Daniel E. Juri, Kieu Do, Amanda M. Bernauer, Cindy L. Thomas, Leah A. Damiani, Mathewos Tessema, Shuguang Leng and Steven A. BelinskyCancer Res April 15 2011 71 (8) 3087-3097; DOI:10.1158/0008-5472.CAN-10-3035
This study extends present concepts of how EMT contributes to cancer progression by showing that it can also contribute to cancer initiation, by promoting clonal expansion and stem-like properties in premalignant lung epithelial cells.
- Tumor and Stem Cell BiologyGianluca Civenni, Anne Walter, Nikita Kobert, Daniela Mihic-Probst, Marie Zipser, Benedetta Belloni, Burkhardt Seifert, Holger Moch, Reinhard Dummer, Maries van den Broek and Lukas SommerCancer Res April 15 2011 71 (8) 3098-3109; DOI:10.1158/0008-5472.CAN-10-3997
Using immunocompetent mouse models and methodologies to better preserve cell surface epitopes allowed the identification of a melanoma stem cell marker associated with metastatic disease.
- Tumor and Stem Cell BiologyQing Chang, Igor Jurisica, Trevor Do and David W. HedleyCancer Res April 15 2011 71 (8) 3110-3120; DOI:10.1158/0008-5472.CAN-10-4049
Results offer experimental proof of the expected powerful effects of hypoxia on the progression of early stage pancreatic cancer, with potential to target these effects therapeutically.
- Tumor and Stem Cell BiologyJude Alsarraj, Renard C. Walker, Joshua D. Webster, Thomas R. Geiger, Nigel P.S. Crawford, R. Mark Simpson, Keiko Ozato and Kent W. HunterCancer Res April 15 2011 71 (8) 3121-3131; DOI:10.1158/0008-5472.CAN-10-4417
Findings suggest how an important metastasis susceptibility gene may predispose tumor cells to convert to more de-differentiated or primitive states that are metastatically aggressive.
- Tumor and Stem Cell BiologyAlessandra Gentile, Luca Lazzari, Silvia Benvenuti, Livio Trusolino and Paolo M. ComoglioCancer Res April 15 2011 71 (8) 3132-3141; DOI:10.1158/0008-5472.CAN-10-2662
An uncharacterized member of the human kinome is revealed to be a pseudokinase that acts downstream of the MET oncoprotein, the activation of which mediates powerful effects on the progression of many types of human cancer.
- Tumor and Stem Cell BiologyKai-Oliver Henrich, Tobias Bauer, Johannes Schulte, Volker Ehemann, Hedwig Deubzer, Sina Gogolin, Daniel Muth, Matthias Fischer, Axel Benner, Rainer König, Manfred Schwab and Frank WestermannCancer Res April 15 2011 71 (8) 3142-3151; DOI:10.1158/0008-5472.CAN-10-3014
Findings define properties of a gene involved in neuronal differentiation that support its assignment as a 1p36 tumor suppressor gene in neuroblastoma.
- Tumor and Stem Cell BiologyJohn Brognard, You-Wei Zhang, Lorena A. Puto and Tony HunterCancer Res April 15 2011 71 (8) 3152-3161; DOI:10.1158/0008-5472.CAN-10-3543
There has been a recent flood of cancer kinome sequence data, but the functional consequences of the reported protein kinase mutations have been inferred largely through statistical approaches, and our studies represent a critical first step in assessing the functional relevance of putative driver mutations experimentally.
- Tumor and Stem Cell BiologyXin-Jian Li, Choon Kiat Ong, Yun Cao, Yan-Qun Xiang, Jian-Yong Shao, Aikseng Ooi, Li-Xia Peng, Wen-Hua Lu, Zhongfa Zhang, David Petillo, Li Qin, Ying-Na Bao, Fang-Jing Zheng, Claramae Shulyn Chia, N. Gopalakrishna Iyer, Tie-Bang Kang, Yi-Xin Zeng, Khee Chee Soo, Jeffrey M. Trent, Bin Tean Teh and Chao-Nan QianCancer Res April 15 2011 71 (8) 3162-3172; DOI:10.1158/0008-5472.CAN-10-3557
Findings of this extensive study define a functionally important extracellular theranostic marker of metastasis in nasopharengeal carcinoma, a common deadly cancer in Asia.
April 2011
Volume 71, Issue 8
Volume 71, Issue 8
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