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About the Cover

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Deleted in liver cancer 1 (DLC1), a tumor suppressor gene frequently inactivated in non-small cell lung cancer (NSCLC) and other malignancies, encodes a multidomain protein with a RhoGTPase-activating domain and a StAR-related lipid transfer (START) domain. By using immunofluorescence, DLC1 was found to colocalize with caveolin 1 (CAV-1), the principal structural component and marker of caveolae in NSCLC cell lines. The interaction between DLC1 and CAV-1 was mapped to the DLC1 START domain and was shown to be necessary for the tumor suppressor activity of DLC1. For details, see article by Du and colleagues on page 4405.

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Cancer Research: 72 (17)
September 2012
Volume 72, Issue 17
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Issue Highlights

  • Functional Interaction of Tumor Suppressor DLC1 and Caveolin-1 in Cancer Cells
  • Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice
  • Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
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Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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