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Prevention and Epidemiology

Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

Caihua Liang, Carmen J. Marsit, Michael D. McClean, Heather H. Nelson, Brock C. Christensen, Robert I. Haddad, John R. Clark, Richard O. Wein, Gregory A. Grillone, E. Andres Houseman, Gordana Halec, Tim Waterboer, Michael Pawlita, Jeffrey F. Krane and Karl T. Kelsey
Caihua Liang
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Carmen J. Marsit
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Michael D. McClean
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Heather H. Nelson
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Brock C. Christensen
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Robert I. Haddad
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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John R. Clark
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Richard O. Wein
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Gregory A. Grillone
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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E. Andres Houseman
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Gordana Halec
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Tim Waterboer
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Michael Pawlita
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Jeffrey F. Krane
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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Karl T. Kelsey
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
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DOI: 10.1158/0008-5472.CAN-11-3277 Published October 2012
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Article Information

Volume 72, Issue 19, pp. 5004-5013

DOI 
https://doi.org/10.1158/0008-5472.CAN-11-3277
PubMed 
22991304

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received October 4, 2011
  • Revision received May 31, 2012
  • Accepted June 15, 2012
  • Published first September 18, 2012.

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  • Previous version (September 18, 2012 - 09:45).
  • You are viewing the most recent version of this article.
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©2012 American Association for Cancer Research.

Author Information

  1. Caihua Liang1,
  2. Carmen J. Marsit3,4,
  3. Michael D. McClean5,
  4. Heather H. Nelson11,
  5. Brock C. Christensen3,4,
  6. Robert I. Haddad6,
  7. John R. Clark7,
  8. Richard O. Wein8,
  9. Gregory A. Grillone9,
  10. E. Andres Houseman12,
  11. Gordana Halec13,
  12. Tim Waterboer13,
  13. Michael Pawlita13,
  14. Jeffrey F. Krane10, and
  15. Karl T. Kelsey1,2
  1. Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
  1. Corresponding Author:
    Karl T. Kelsey, Department of Epidemiology and Department of Pathology and Laboratory Medicine, Brown University, Providence, RI. Phone: 401-863-6420; Fax: 401-863-9008; E-mail: Karl_Kelsey{at}brown.edu
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Cancer Research: 72 (19)
October 2012
Volume 72, Issue 19
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Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
Caihua Liang, Carmen J. Marsit, Michael D. McClean, Heather H. Nelson, Brock C. Christensen, Robert I. Haddad, John R. Clark, Richard O. Wein, Gregory A. Grillone, E. Andres Houseman, Gordana Halec, Tim Waterboer, Michael Pawlita, Jeffrey F. Krane and Karl T. Kelsey
Cancer Res October 1 2012 (72) (19) 5004-5013; DOI: 10.1158/0008-5472.CAN-11-3277

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Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
Caihua Liang, Carmen J. Marsit, Michael D. McClean, Heather H. Nelson, Brock C. Christensen, Robert I. Haddad, John R. Clark, Richard O. Wein, Gregory A. Grillone, E. Andres Houseman, Gordana Halec, Tim Waterboer, Michael Pawlita, Jeffrey F. Krane and Karl T. Kelsey
Cancer Res October 1 2012 (72) (19) 5004-5013; DOI: 10.1158/0008-5472.CAN-11-3277
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