Prevention and Epidemiology
Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
Caihua Liang, Carmen J. Marsit, Michael D. McClean, Heather H. Nelson, Brock C. Christensen, Robert I. Haddad, John R. Clark, Richard O. Wein, Gregory A. Grillone, E. Andres Houseman, Gordana Halec, Tim Waterboer, Michael Pawlita, Jeffrey F. Krane and Karl T. Kelsey
Caihua Liang
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Carmen J. Marsit
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Michael D. McClean
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Heather H. Nelson
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Brock C. Christensen
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Robert I. Haddad
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
John R. Clark
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Richard O. Wein
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Gregory A. Grillone
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
E. Andres Houseman
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Gordana Halec
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Tim Waterboer
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Michael Pawlita
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Jeffrey F. Krane
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Karl T. Kelsey
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
DOI: 10.1158/0008-5472.CAN-11-3277 Published October 2012

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Volume 72, Issue 19, pp. 5004-5013
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History
- Received October 4, 2011
- Revision received May 31, 2012
- Accepted June 15, 2012
- Published first September 18, 2012.
Article Versions
- Previous version (September 18, 2012 - 09:45).
- You are viewing the most recent version of this article.
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©2012 American Association for Cancer Research.
Author Information
- Caihua Liang1,
- Carmen J. Marsit3,4,
- Michael D. McClean5,
- Heather H. Nelson11,
- Brock C. Christensen3,4,
- Robert I. Haddad6,
- John R. Clark7,
- Richard O. Wein8,
- Gregory A. Grillone9,
- E. Andres Houseman12,
- Gordana Halec13,
- Tim Waterboer13,
- Michael Pawlita13,
- Jeffrey F. Krane10, and
- Karl T. Kelsey1,2
- Authors' Affiliations: Departments of 1Epidemiology and 2Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island; Departments of 3Pharmacology and Toxicology and 4Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire; 5Department of Environmental Health, School of Public Health, Boston University; 6Department of Medical Oncology/Solid Tumor Oncology, Dana-Farber Cancer Institute; 7Department of Medicine Hematology/Oncology, Massachusetts General Hospital; 8Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center; 9Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, Massachusetts; 10Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts; 11Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota; 12College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; and 13Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany
- Corresponding Author:
Karl T. Kelsey, Department of Epidemiology and Department of Pathology and Laboratory Medicine, Brown University, Providence, RI. Phone: 401-863-6420; Fax: 401-863-9008; E-mail: Karl_Kelsey{at}brown.edu
October 2012
Volume 72, Issue 19
Volume 72, Issue 19
Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
Caihua Liang, Carmen J. Marsit, Michael D. McClean, Heather H. Nelson, Brock C. Christensen, Robert I. Haddad, John R. Clark, Richard O. Wein, Gregory A. Grillone, E. Andres Houseman, Gordana Halec, Tim Waterboer, Michael Pawlita, Jeffrey F. Krane and Karl T. Kelsey
Cancer Res October 1 2012 (72) (19) 5004-5013; DOI: 10.1158/0008-5472.CAN-11-3277
Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma
Caihua Liang, Carmen J. Marsit, Michael D. McClean, Heather H. Nelson, Brock C. Christensen, Robert I. Haddad, John R. Clark, Richard O. Wein, Gregory A. Grillone, E. Andres Houseman, Gordana Halec, Tim Waterboer, Michael Pawlita, Jeffrey F. Krane and Karl T. Kelsey
Cancer Res October 1 2012 (72) (19) 5004-5013; DOI: 10.1158/0008-5472.CAN-11-3277
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