Table of Contents

Microenvironment and Immunology

• Microenvironment and Immunology

  Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis

  Takashi Tanikawa, Cailin Moira Wilke, Ilona Kryczek, Grace Y. Chen, John Kao, Gabriel Núñez and Weiping Zou

  Cancer Res January 15 2012 72 (2) 420-429; DOI:10.1158/0008-5472.CAN-10-4627

  
  

  This study of cancer susceptibility and progression in mice lacking IL-10 challenges the generally held view that this immune inhibitory cytokine supports cancer, instead offering powerful evidence that endogenous IL-10 actually suppresses cancer by impeding the development of 2 key cellular mechanisms of immune escape.

• Microenvironment and Immunology

  Potent Induction of Tumor Immunity by Combining Tumor Cryoablation with Anti–CTLA-4 Therapy

  Rebecca Waitz, Stephen B. Solomon, Elena N. Petre, Anne E. Trumble, Marcella Fassò, Larry Norton and James P. Allison

  Cancer Res January 15 2012 72 (2) 430-439; DOI:10.1158/0008-5472.CAN-11-1782

  
  

  One use of the recently approved immune activating drug ipilumimab may be to enhance the benefits of tumor cryoablation, a simple older treatment strategy being explored anew in breast and prostate cancers, where it might be very effectively combined with immunotherapy to enhance cure rates in patients with localized tumors.

• Microenvironment and Immunology

  Platelet-Derived MHC Class I Confers a Pseudonormal Phenotype to Cancer Cells That Subverts the Antitumor Reactivity of Natural Killer Immune Cells

  Theresa Placke, Melanie Örgel, Martin Schaller, Gundram Jung, Hans-Georg Rammensee, Hans-Georg Kopp and Helmut Rainer Salih

  Cancer Res January 15 2012 72 (2) 440-448; DOI:10.1158/0008-5472.CAN-11-1872

  
  

  This important paper elucidates a fascinating mechanism of immune escape from NK cells in which platelets function to shield cancer cells and promote their metastatic spread.

• Microenvironment and Immunology

  Chromogranin A Regulates Tumor Self-Seeding and Dissemination

  Eleonora Dondossola, Luca Crippa, Barbara Colombo, Elisabetta Ferrero and Angelo Corti

  Cancer Res January 15 2012 72 (2) 449-459; DOI:10.1158/0008-5472.CAN-11-2944

  
  

  Findings define a role for a circulating regulator of multidirectional trafficking of tumor cells between tumors, blood, and normal tissues, with general implications for metastasis formation and tumor progression.

• Microenvironment and Immunology

  Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

  Anja Heinemann, Fang Zhao, Sonali Pechlivanis, Jürgen Eberle, Alexander Steinle, Sven Diederichs, Dirk Schadendorf and Annette Paschen

  Cancer Res January 15 2012 72 (2) 460-471; DOI:10.1158/0008-5472.CAN-11-1977

  
  

  The perspective that tumor suppressor functions often manifest as immune responses against tumor cells is quickly widening with broader investigations in more valid immunocompetent models of cancer.