Table of Contents

Poster Presentations

• Proffered Abstracts

  Abstract A1: Long stress-induced non-coding transcripts (LSINCTs) and Cancer

  David I. Smith and Silva M. Jessica

  Cancer Res January 8 2012 72 (2 Supplement) A1-A1; DOI:10.1158/1538-7445.NONRNA12-A1

  
  
• Proffered Abstracts

  Abstract A2: miR-10a regulation of PIK3CA and response to taxol in non small cell lung cancer

  Chris DeSevo, Liqin Du, Carmen Behrens, Ignacio I. Wistuba, John Minna and Alexander Pertsemlidis

  Cancer Res January 8 2012 72 (2 Supplement) A2-A2; DOI:10.1158/1538-7445.NONRNA12-A2

  
  
• Proffered Abstracts

  Abstract A3: miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer

  Katarzyna Augoff, Brian McCue, Edward F. Plow and Khalid Sossey-Alaoui

  Cancer Res January 8 2012 72 (2 Supplement) A3-A3; DOI:10.1158/1538-7445.NONRNA12-A3

  
  
• Proffered Abstracts

  Abstract A5: Cytotoxic Extracts of Ethnomedicinal Plants: Podophyllum peltatum (Mayapple) and Echinacea angustifolia

  Olena T. James and E. Lewis Myles

  Cancer Res January 8 2012 72 (2 Supplement) A5-A5; DOI:10.1158/1538-7445.NONRNA12-A5

  
  
• Proffered Abstracts

  Abstract A6: microRNA sequencing of AKXD recombinant inbred panel identifies miR-216b as a candidate metastasis suppressor in a murine model of breast cancer

  Farhoud Faraji, Ying Hu, Natalie Goldberger, Gang Wu, Ken H. Buetow, Jinghui Zhang and Kent W. Hunter

  Cancer Res January 8 2012 72 (2 Supplement) A6-A6; DOI:10.1158/1538-7445.NONRNA12-A6

  
  
• Proffered Abstracts

  Abstract A7: Roles of miRNAs in the switch of TGF-β from tumor suppressor to pro-oncogenic factor in cancer progression

  Yoshiko Nagano, Maxwell P. Lee and Lalage M. Wakefield

  Cancer Res January 8 2012 72 (2 Supplement) A7-A7; DOI:10.1158/1538-7445.NONRNA12-A7

  
  
• Proffered Abstracts

  Abstract A8: Defining specific microRNAs that cooperatively regulate GRP78, an ER chaperone and signaling regulator, in cancer

  Sheng-Fang Su, Amy S. Lee and Gangning Liang

  Cancer Res January 8 2012 72 (2 Supplement) A8-A8; DOI:10.1158/1538-7445.NONRNA12-A8

  
  
• Proffered Abstracts

  Abstract A9: De novo sequencing of circulating microRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer

  Xiwei Wu, George Somlo, Melanie Palomares, Yun Yen, John Rossi, Harry Gao and Shizhen Emily Wang

  Cancer Res January 8 2012 72 (2 Supplement) A9-A9; DOI:10.1158/1538-7445.NONRNA12-A9

  
  
• Proffered Abstracts

  Abstract A10: MicroRNA 27a is downreguated in cisplatin resistant bladder cancer cells, and contributes to resistance through the targeting of xCT, a cystine transporter involved with glutathione production

  Ross M. Drayton, Ewa Dudziec, James W.F. Catto and Helen E. Bryant

  Cancer Res January 8 2012 72 (2 Supplement) A10-A10; DOI:10.1158/1538-7445.NONRNA12-A10

  
  
• Proffered Abstracts

  Abstract A12: Identification of microRNA-based therapeutic candidates using a unique lentiviral microRNA overexpression library

  Paula I. van Noort, Negar Babae, Gerald W. Verhaegh, Willemijn M. Gommans, Francesco Cerisoli, Mark Verheul, Raymond M. Schiffelers, Arjan W. Griffioen, Jack A. Schalken, Eugene Berezikov, Edwin Cuppen, Roel Q. J. Schaapveld, Jos B. Poell, Gregoire P. Prevost, Meriem Bourajjaj, Suzanna Vidic, Judy R. van Beijnum, Rick J. van Haastert, Iman Schultz, Thijs de Gunt and Onno van Hooij

  Cancer Res January 8 2012 72 (2 Supplement) A12-A12; DOI:10.1158/1538-7445.NONRNA12-A12

  
  
• Proffered Abstracts

  Abstract A13: The microRNA-200 family overcomes cisplatin resistance by targeting ceramide glycosylation

  Chunxiao Cai, Hassan Ashktorab, Xiaowu Pang, Yuan Zhao, Wei Sha, Yulan Liu and Xinbin Gu

  Cancer Res January 8 2012 72 (2 Supplement) A13-A13; DOI:10.1158/1538-7445.NONRNA12-A13

  
  
• Proffered Abstracts

  Abstract A14: microRNA-mediated interactions regulate established oncongenic pathways in cancer

  Pavel Sumazin, Hua-Sheng Chiu and Andrea Califano

  Cancer Res January 8 2012 72 (2 Supplement) A14-A14; DOI:10.1158/1538-7445.NONRNA12-A14

  
  
• Proffered Abstracts

  Abstract A16: MiR-22 down-regulation via epigenetic control in oral cancer cells

  Li-Wha Wu

  Cancer Res January 8 2012 72 (2 Supplement) A16-A16; DOI:10.1158/1538-7445.NONRNA12-A16

  
  
• Proffered Abstracts

  Abstract A17: MiR-15, miR-16 and miR-21 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation and apoptosis

  Matan Ofir, Berta Ben-Shachar, Dalia Hacohen and Doron Ginsberg

  Cancer Res January 8 2012 72 (2 Supplement) A17-A17; DOI:10.1158/1538-7445.NONRNA12-A17

  
  
• Proffered Abstracts

  Abstract A18: p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

  Taewan Kim, Tae Jin Lee, Young-Jun Jeon, Pascal Pineau, Anne Dejean and Carlo Maria Croce

  Cancer Res January 8 2012 72 (2 Supplement) A18-A18; DOI:10.1158/1538-7445.NONRNA12-A18

  
  
• Proffered Abstracts

  Abstract A19: Profiling long noncoding RNA expression in cancer cells by real-time PCR arrays

  Fangting Wu and Yin-Yuan Mo

  Cancer Res January 8 2012 72 (2 Supplement) A19-A19; DOI:10.1158/1538-7445.NONRNA12-A19

  
  
• Proffered Abstracts

  Abstract A20: The Six1-regulated miR-106b-25 cluster is a mediator of the tumor promotional effects of TGF-β signaling in human breast cancer

  Anna L. Smith, Ritsuko Iwanaga, David J. Drasin, Douglas S. Micalizzi, Rebecca L. Vartuli and Heide L. Ford

  Cancer Res January 8 2012 72 (2 Supplement) A20-A20; DOI:10.1158/1538-7445.NONRNA12-A20

  
  
• Proffered Abstracts

  Abstract A21: MALAT-1 is essential for lung cancer metastasis in a novel human knockout model

  Tony Gutschner, Moritz Eißmann, Monika Hämmerle, Marion Stentrup, Catherina Hildenbrandt, Matthias Groß, Martin Zörnig and Sven Diederichs

  Cancer Res January 8 2012 72 (2 Supplement) A21-A21; DOI:10.1158/1538-7445.NONRNA12-A21

  
  
• Proffered Abstracts

  Abstract A23: A non-coding RNA panel predicts intermediate-risk childhood rhabdomyosarcoma prognosis better than standard pathologic criteria and coding genes

  Anirban P. Mitra, Jonathan D. Buckley, Sheetal A. Mitra, Elai Davicioni, James R. Anderson, Philipp Kapranov, Stephen X. Skapek, Douglas S. Hawkins and Timothy J. Triche

  Cancer Res January 8 2012 72 (2 Supplement) A23-A23; DOI:10.1158/1538-7445.NONRNA12-A23

  
  
• Proffered Abstracts

  Abstract A24: Interaction of miR-106a~363^Xpcl1 and p27^Kip1 in thymopoiesis and lymphomagenesis

  Daniel Kuppers, Thomas Schmitt, Bruce Clurman, Harry Hwang and Matthew L. Fero

  Cancer Res January 8 2012 72 (2 Supplement) A24-A24; DOI:10.1158/1538-7445.NONRNA12-A24

  
  
• Proffered Abstracts

  Abstract A25: Differences in microRNA expression patterns in breast cancer subtypes

  Sandra L. Romero-Cordoba, Rosa G. Rebollar-Vega, Valeria Quintanar-Jurado, Veronica Bautista-Pina, Sergio Rodriguez-Cuevas, Antonio Maffuz-Aziz and Alfredo Hidalgo-Miranda

  Cancer Res January 8 2012 72 (2 Supplement) A25-A25; DOI:10.1158/1538-7445.NONRNA12-A25

  
  
• Proffered Abstracts

  Abstract A26: DNA copy number alterations deregulate expression of miRNAs in lung adenocarcinoma

  Greg L. Stewart, Katey SS Enfield, Stephen Lam and Wan Lam

  Cancer Res January 8 2012 72 (2 Supplement) A26-A26; DOI:10.1158/1538-7445.NONRNA12-A26

  
  
• Proffered Abstracts

  Abstract A27: MicroRNA 21 in adipocyte-derived microvesicles confers taxol-resistance of ovarian cancer cells through down-regulation of Apoptotic Protease Activating Factor 1

  Ngai Na Co, Rosemarie Schmandt, Karen Lu and Samuel Mok

  Cancer Res January 8 2012 72 (2 Supplement) A27-A27; DOI:10.1158/1538-7445.NONRNA12-A27

  
  
• Proffered Abstracts

  Abstract A28: DD3/PCA3 non-coding RNA regulates prostate cancer cell survival and modulates AR signaling

  Luciana Ferreira, Antonio Palumbo, Kivvi Mello, Felipe Leite, Cinthya Sternberg, Mauricio Caetano, Adriana Neves, Luiz Ricardo Goulart and Etel Gimba

  Cancer Res January 8 2012 72 (2 Supplement) A28-A28; DOI:10.1158/1538-7445.NONRNA12-A28

  
  
• Proffered Abstracts

  Abstract A29: Notch-dependent modulation of microRNAs in rhabdomyosarcoma

  Rossella Rota Sr., Roberta Ciarapica Jr., Letizia Da Sacco Jr., Maria De Salvo Jr., Andrea Masotti Sr., Lucio Miele Sr. and Franco Locatelli Sr.

  Cancer Res January 8 2012 72 (2 Supplement) A29-A29; DOI:10.1158/1538-7445.NONRNA12-A29

  
  
• Proffered Abstracts

  Abstract A30: miRNA Regulators of Ovarian Cancer Metastasis that Predict Patient Outcomes

  Alexander S. Brodsky, Hsin-Ta Wu, Souriya Vang, Benjamin Raphael and Laurent Brard

  Cancer Res January 8 2012 72 (2 Supplement) A30-A30; DOI:10.1158/1538-7445.NONRNA12-A30

  
  
• Proffered Abstracts

  Abstract A31: Differential processing of let-7a precursors influences gemcitabine chemosensitivity in pancreatic cancer: Role of ribonucleotide reductase subunit M2

  Rajgopal Govindarajan

  Cancer Res January 8 2012 72 (2 Supplement) A31-A31; DOI:10.1158/1538-7445.NONRNA12-A31

  
  
• Proffered Abstracts

  Abstract A33: The role of microRNA-181a in TGF-β-mediated breast cancer progression

  Molly A. Taylor and William P. Schiemann

  Cancer Res January 8 2012 72 (2 Supplement) A33-A33; DOI:10.1158/1538-7445.NONRNA12-A33

  
  
• Proffered Abstracts

  Abstract B4: MicroRNAs differentially expressed in preoperative human serum of ovarian cancer

  Angel Chao, Tzu Hao Wang, Hua-Chien Chen, Shu-Jen Chen and Chyong-Huey Lai

  Cancer Res January 8 2012 72 (2 Supplement) B4-B4; DOI:10.1158/1538-7445.NONRNA12-B4

  
  
• Proffered Abstracts

  Abstract B6: Human genome contains a large number of very long intergenic transcribed regions, some of which are associated with cancer outcome

  Anirban P. Mitra, Timothy J. Triche, Sheetal A. Mitra, Jonathan D. Buckley, Poul H. B. Sorensen, C Patrick Reynolds, Robert J. Arceci, Patrice Milos, Georges St. Laurent and Philipp Kapranov

  Cancer Res January 8 2012 72 (2 Supplement) B6-B6; DOI:10.1158/1538-7445.NONRNA12-B6

  
  
• Proffered Abstracts

  Abstract B7: microRNA regulation of cell viability and drug sensitivity in lung cancer

  Liqin Du, Christopher DeSevo, Borkowski Robert, Baker Michael, Adi F. Gazdar, John D. Minna and Alexander Pertsemlidis

  Cancer Res January 8 2012 72 (2 Supplement) B7-B7; DOI:10.1158/1538-7445.NONRNA12-B7

  
  
• Proffered Abstracts

  Abstract B9: Critical Early microRNA-Mediated Signalling Events During ATRA Induced Neuroblastoma Cell Differentiation

  Niamh H. Foley, Isabella M. Bray, Raquel Fernandez and Raymond L. Stallings

  Cancer Res January 8 2012 72 (2 Supplement) B9-B9; DOI:10.1158/1538-7445.NONRNA12-B9

  
  
• Proffered Abstracts

  Abstract B10: Genome-wide profiling reveals hyper- and hypomethylation at microRNA promoters in chronic lymphocytic leukemia

  Constance Baer, Michael Rehli, John C. Byrd, Clemens-Martin Wendtner, Christoph Plass, Rainer Claus, Lukas Frenzel, Manuela Zucknick, Yoon Jung Park, Lei Gu, Dieter Weichenhan, Martina Fischer and Christian Pallasch

  Cancer Res January 8 2012 72 (2 Supplement) B10-B10; DOI:10.1158/1538-7445.NONRNA12-B10

  
  
• Proffered Abstracts

  Abstract B11: Expression of microRNAs-135b and -196b in response to cellular stress in leukemia cells

  Tsui-Ting Ho, Xiaolong He, Ahmet Dirim Arslan and William T. Beck

  Cancer Res January 8 2012 72 (2 Supplement) B11-B11; DOI:10.1158/1538-7445.NONRNA12-B11

  
  
• Proffered Abstracts

  Abstract B12: The miR-15 family and miR-155 mediate WEE1 and CHEK1 effects on cisplatin-resistance in cancer cells

  Lynn M. Pouliot, Jennifer Bai, Matthew D. Hall, Scott E. Martin and Michael M. Gottesman

  Cancer Res January 8 2012 72 (2 Supplement) B12-B12; DOI:10.1158/1538-7445.NONRNA12-B12

  
  
• Proffered Abstracts

  Abstract B13: Automated multiplex assay for diagnostic application of contextual microRNA signatures in breast cancer

  Wendy Wells, Sung-hee Choi, Gary Schwartz and Lorenzo F. Sempere

  Cancer Res January 8 2012 72 (2 Supplement) B13-B13; DOI:10.1158/1538-7445.NONRNA12-B13

  
  
• Proffered Abstracts

  Abstract B14: Anti-miR-135b in colon cancer treatment

  Nicola Valeri, Roberta Gafa', Gerard Nuovo, Giovanni Lanza, Wendy Frankel, Peter K. Vogt, Joanna Groden, Michael Karin, Carlo M. Croce, Chiara Braconi, Pierluigi Gasparini, Sergei Grivennikov, Jonathan R. Hart, Alessio Paone, Francesca Lovat and Muller Fabbri

  Cancer Res January 8 2012 72 (2 Supplement) B14-B14; DOI:10.1158/1538-7445.NONRNA12-B14

  
  
• Proffered Abstracts

  Abstract B15: Repression of PDGFRA-targeting miR-34a promotes tumorigenesis in proneural malignant gliomas

  Joachim Silber, Anders Jacobsen, Tatsuya Ozawa, Girish Harinath, Eric C. Holland, Chris Sander and Jason T. Huse

  Cancer Res January 8 2012 72 (2 Supplement) B15-B15; DOI:10.1158/1538-7445.NONRNA12-B15

  
  
• Proffered Abstracts

  Abstract B17: Inhibition of lung tumor progression in a metastatic mouse model following intravenous delivery of siRNA nanocomplexes

  Jason G. Fewell, Khursheed Anwer, Kevin Polach, Majed Matar, Jennifer Rice, Angela Rea-Ramsey, Jeff Sparks, Diane McClure, Casey Pence, Elaine Brunhoeber and Leslie Wilkinson

  Cancer Res January 8 2012 72 (2 Supplement) B17-B17; DOI:10.1158/1538-7445.NONRNA12-B17

  
  
• Proffered Abstracts

  Abstract B18: The transcribed non-coding genome modulates the biology of Ewing sarcoma family of tumors

  Sheetal A. Mitra, Daniel H. Wai, William A. May, Jonathan D. Buckley, Philipp Kapranov, Robert J. Arceci and Timothy J. Triche

  Cancer Res January 8 2012 72 (2 Supplement) B18-B18; DOI:10.1158/1538-7445.NONRNA12-B18

  
  
• Proffered Abstracts

  Abstract B20: Breast cancer progression suppressor miR-290 targets breast cancer biomarker Arid4b

  Natalie Goldberger, Renard Walker, Chang Hee Kim and Kent Hunter

  Cancer Res January 8 2012 72 (2 Supplement) B20-B20; DOI:10.1158/1538-7445.NONRNA12-B20

  
  
• Proffered Abstracts

  Abstract B21: The paralogous microRNA clusters, miR-17-92 and miR-106-25, are specifically overexpressed in metastatic non-small cell lung carcinomas

  Katey SS Enfield, Stephen Lam and Wan L. Lam

  Cancer Res January 8 2012 72 (2 Supplement) B21-B21; DOI:10.1158/1538-7445.NONRNA12-B21

  
  
• Proffered Abstracts

  Abstract B23: Selective inhibition of a long non-coding RNA (lncRNA), MALAT1 by antisense oligonucleotides results in significant anti-tumor effects in a variety of preclinical cancer models

  Jeff Hsu, Guobin He, Gourab Bhattacharjee, Tianyuan Zhou, Chris May, Xiaokun Xiao, Gene Hung, Brett P. Monia, A. Robert MacLeod and Youngsoo Kim

  Cancer Res January 8 2012 72 (2 Supplement) B23-B23; DOI:10.1158/1538-7445.NONRNA12-B23

  
  
• Proffered Abstracts

  Abstract B24: New views on microRNAs involvement in melanoma

  Eyal Greenberg, Eran Eyal, Gideon Rechavi, Noam Shomron, Jacob Schachter, Gal Markel, Yael Nemlich, Steven Hajdu, Orit Itzhaki, Liat Edry, Oz Solomon, Ninette Amariglio, Michal J. Besser and Yona Keisari

  Cancer Res January 8 2012 72 (2 Supplement) B24-B24; DOI:10.1158/1538-7445.NONRNA12-B24

  
  
• Proffered Abstracts

  Abstract B28: MicroRNA-641 activates MAPK by targeting NF1 and cooperates with its host gene AKT2 in human cancer

  Edward J. Richards, Marc Coppola, Jianping Guo, William Kong and Jin Q. Cheng

  Cancer Res January 8 2012 72 (2 Supplement) B28-B28; DOI:10.1158/1538-7445.NONRNA12-B28

  
  
• Proffered Abstracts

  Abstract B30: Exogenous miR-128 Enforced HNSCC Inhibits Proliferation

  Belinda Hauser, Yubin Hao, Joseph Califano and Xinbin Gu

  Cancer Res January 8 2012 72 (2 Supplement) B30-B30; DOI:10.1158/1538-7445.NONRNA12-B30