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About the Cover

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Galectins, a family of endogenous glycan-binding proteins, play different roles in tumor-related processes including tumor transformation, metastasis, angiogenesis, and tumor-immune escape. In spite of considerable progress in elucidating the role of individual galectins in tumor biology, an integrated portrait of the galectin network in different tumor microenvironments is missing. Laderach and colleagues identified a unique galectin signature during human prostate cancer progression characterized by lower levels of galectins-3, -4, -9 and -12, no changes in galectin-8 expression, and dramatic upregulation of galectin-1. In human prostate cancer tissue, galectin-1 expression correlated with the presence of blood vessels in advanced disease. This endogenous lectin promoted prostate cancer angiogenesis through mechanisms that were independent of classical proangiogenic factors, suggesting a tractable independent target for prostate cancer therapy in advanced stages of the disease. For details, please see the article by Laderach and colleagues on page 86.

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Cancer Research: 73 (1)
January 2013
Volume 73, Issue 1
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Issue Highlights

  • A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1 as a Key Target for Treatment of Advanced Disease
  • Dose-Dense Chemotherapy Improves Mechanisms of Antitumor Immune Response
  • Autophagy Control by the VEGF-C/NRP-2 Axis in Cancer and Its Implication for Treatment Resistance
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Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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