Breaking Advances
Cancer Res March 1 2013 73 (5) 1447-1448;
Chromothripsis and focal copy number alterations determine poor outcome in patients with malignant melanoma, suggesting a role of chromothripsis as a genetic marker of aggressive cancer types.
Important mechanistic findings offer an explanation for the long-standing question why testicular cancers are so susceptible to eradication with cisplatin treatment.
Findings offer compelling evidence for complementary strengths of MRI and PET for noninvasive in vivo imaging of choline metabolism that is broadly important in cancer growth and progression.
Different types of radiation treatment for aggressive brain tumors exert distinct effects on stem cells, with profound implications for treatment regimens used currently.
A class of molecules regulating cell polarity in circulating chronic lymphocytic leukemia cells mediates key pathogenic interactions with their microenvironment that determine prognosis.
Circulating proteins, free autoantibodies, and protein-antibody complexes are defined in breast cancer patients, with possible implications for earlier detection of disease.
Several distinct types of immune regulatory cells influence tumor immunity at the same time in a tumor, but their balance depends on T cells coordinately controlling them, possibly impacting immunotherapeutic strategies.
Striking findings show that tumor invasion into adjacent normal tissues proceeds in the direction of low pH and that simply lowering the acidity of adjacent tissues in vivo by administering sodium bicarbonate is sufficient to block invasion.
Strategies to alter interstitial flow patterns in brain tumors may combat invasive dissemination and therapeutic failures occurring in this disease.
A nanoparticle-based platform for intratumoral delivery of potent immunotherapeutic agents enables antitumor immunity while avoiding systemic toxicities.
A factor associated previously with angiogenesis support is found to control the aggressiveness and self-renewal potential of glioblastoma, the most common and deadly primary adult brain tumor.
The findings of this study raise questions about the precise specificity of accepted androgen receptor pathways in castration-resistant prostate tumors under androgen-deprived states.
A homeobox transcription factor implicated in mesenchymal differentiation and craniofacial development upregulates the EMT regulator Snail to drive invasion and metastasis.
Results identify a chromatin modifier that may act through the same pathways as MLL chimeric proteins in driving a variety of hematopoietic cancers.
Obesity and low physical activity associate with increased risk of colorectal cancers that do not involve β-catenin, the chief target of the WNT pathway, but not risk of β-catenin-positive colorectal cancers, which may be more aggressive.
The tyrosine kinase inhibitor Gleevec may have additional uses to radiosensitize tumors that are defective in non-homologous end joining (NHEJ), with the potential to greatly expand clinical applications of this agent.
Findings suggest how XRCC1 deficiency in breast cancer can inform choice of targeted chemotherapies for treatment, based on the synthetic lethality that can be achieved with the inhibition of particular mechanisms of DNA double-strand break repair.
HER2 selectively regulates the cancer stem cell population in luminal breast cancers, perhaps explaining the clinical benefits of adjuvant trastuzumab therapy in tumors where the HER2 gene is not amplified.