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Cancer Research
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About the Cover

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Cancer stem cells are implicated in tumor metastasis although the exact mechanisms remain poorly understood. The expression of cellular prion protein (PrPc), a highly conserved glycoprotein that has the same protein sequence as the scrapie prion protein, is positively correlated with an increased risk of metastasis in colorectal cancer. By double immunofluorescence staining of CD44 (green) and PrPc (red), CD44+PrPc+ cells were detected in the cryosections of colorectal cancers. PrPc+CD44+ colorectal cancer stem cells displayed high liver metastatic capability. For details, see article by Du and colleagues on page 2682.

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Cancer Research: 73 (8)
April 2013
Volume 73, Issue 8
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Issue Highlights

  • CD44-Positive Cancer Stem Cells Expressing Cellular Prion Protein Contribute to Metastatic Capacity in Colorectal Cancer
  • Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis
  • Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells
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Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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