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Table of Contents

Breaking Advances

  • Breaking Advances
    Highlights from Recent Cancer Literature
    Cancer Res April 1 2014 74 (7) 1883-1884;

Reviews

  • Reviews
    Obesity and Cancer: A Gut Microbial Connection
    Naoko Ohtani, Shin Yoshimoto and Eiji Hara
    Cancer Res April 1 2014 74 (7) 1885-1889; DOI:10.1158/0008-5472.CAN-13-3501

  • Reviews | AuthorChoice
    Transforming Growth Factor-β as a Therapeutic Target in Hepatocellular Carcinoma
    Gianluigi Giannelli, Erica Villa and Michael Lahn
    Cancer Res April 1 2014 74 (7) 1890-1894; DOI:10.1158/0008-5472.CAN-14-0243

Priority Report

  • Priority Report
    A Common Cancer-Associated DNA Polymerase ε Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading
    Daniel P. Kane and Polina V. Shcherbakova
    Cancer Res April 1 2014 74 (7) 1895-1901; DOI:10.1158/0008-5472.CAN-13-2892

    This study describes the functional consequences of the most frequent DNA polymerase variant linked to colorectal and endometrial cancer, challenging the recently forwarded idea that hypermutated human cancers must result from loss of exonucleolytic proofreading.

Integrated Systems and Technologies

  • Integrated Systems and Technologies | AuthorChoice
    Noninvasive Quantification of Solid Tumor Microstructure Using VERDICT MRI
    Eletheria Panagiotaki, Simon Walker-Samuel, Bernard Siow, S. Peter Johnson, Vineeth Rajkumar, R. Barbara Pedley, Mark F. Lythgoe and Daniel C. Alexander
    Cancer Res April 1 2014 74 (7) 1902-1912; DOI:10.1158/0008-5472.CAN-13-2511

    This article highlights the superior qualities of a novel noninvasive imaging method to monitor tumor development and therapeutic response in preclinical models.

  • Integrated Systems and Technologies
    Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
    Thomas G. Weber, Franz Osl, Anja Renner, Thomas Pöschinger, Stefanie Galbán, Alnawaz Rehemtulla and Werner Scheuer
    Cancer Res April 1 2014 74 (7) 1913-1923; DOI:10.1158/0008-5472.CAN-13-3001

    This preclinical study reports a method to quantify antibody accumulation and pharmacodynamics in brain tumors, where delivery after systemic administration is often difficult to assess, offering a holistic in vivo approach to assess CNS-targeting drugs.

Microenvironment and Immunology

  • Microenvironment and Immunology
    VISTA Is an Immune Checkpoint Molecule for Human T Cells
    J. Louise Lines, Eirini Pantazi, Justin Mak, Lorenzo F. Sempere, Li Wang, Samuel O'Connell, Sabrina Ceeraz, Arief A. Suriawinata, Shaofeng Yan, Marc S. Ernstoff and Randolph Noelle
    Cancer Res April 1 2014 74 (7) 1924-1932; DOI:10.1158/0008-5472.CAN-13-1504

    Therapeutic inactivation of CTLA-4–related molecules like VISTA may have enormous potential for generalized immunotherapy of cancer.

  • Microenvironment and Immunology
    VISTA Regulates the Development of Protective Antitumor Immunity
    Isabelle Le Mercier, Wenna Chen, Janet L. Lines, Maria Day, Jiannan Li, Petra Sergent, Randolph J. Noelle and Li Wang
    Cancer Res April 1 2014 74 (7) 1933-1944; DOI:10.1158/0008-5472.CAN-13-1506

    This study offers a preclinical proof-of-concept to evaluate the efficacy and mechanisms of action of a VISTA-targeting antibody in multiple tumor models.

  • Microenvironment and Immunology
    Vaccine-Mediated Immunotherapy Directed against a Transcription Factor Driving the Metastatic Process
    Andressa Ardiani, Sofia R. Gameiro, Claudia Palena, Duane H. Hamilton, Anna Kwilas, Thomas H. King, Jeffrey Schlom and James W. Hodge
    Cancer Res April 1 2014 74 (7) 1945-1957; DOI:10.1158/0008-5472.CAN-13-2045

    This study offers a preclinical proof-of-concept for an antimetastasis vaccine targeting Twist, a transcription factor that promotes metastasis and drug resistance in many tumor types.

  • Microenvironment and Immunology
    T Lymphocytes Restrain Spontaneous Metastases in Permanent Dormancy
    Irene Romero, Cristina Garrido, Ignacio Algarra, Antonia Collado, Federico Garrido and Angel M. Garcia-Lora
    Cancer Res April 1 2014 74 (7) 1958-1968; DOI:10.1158/0008-5472.CAN-13-2084

    This study describes a preclinical model for dormant metastases controlled by the immune system, an understanding of which may lead to new insights into how to extend survival by blocking relapses of metastatic cancer.

  • Microenvironment and Immunology
    IL-17A Produced by γδ T Cells Promotes Tumor Growth in Hepatocellular Carcinoma
    Shoubao Ma, Qiao Cheng, Yifeng Cai, Huanle Gong, Yan Wu, Xiao Yu, Liyun Shi, Depei Wu, Chen Dong and Haiyan Liu
    Cancer Res April 1 2014 74 (7) 1969-1982; DOI:10.1158/0008-5472.CAN-13-2534

    These findings offer new insights into how the proinflammatory cytokine IL-17A influences tumor immunity, with potential implications for the development of tumor immunotherapy.

Molecular and Cellular Pathobiology

  • Molecular and Cellular Pathobiology
    β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
    Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon, Wanguo Liu, Lionel Larue and Jacky Bonaventure
    Cancer Res April 1 2014 74 (7) 1983-1995; DOI:10.1158/0008-5472.CAN-13-0920

    ICAT inhibition reduces the mesenchymal amoeboid transition involved in invasive cancer cell motility, limiting metastasis formation.

  • Molecular and Cellular Pathobiology
    Src Kinase Is a Novel Therapeutic Target in Lymphangioleiomyomatosis
    Alexey Tyryshkin, Abhisek Bhattacharya and N. Tony Eissa
    Cancer Res April 1 2014 74 (7) 1996-2005; DOI:10.1158/0008-5472.CAN-13-1256

    This study provides a mechanistic rationale to immediately reposition the use of Src inhibitors currently in clinical trials for the treatment of malignancies associated with mutation of the tumor suppressor gene TSC2.

  • Molecular and Cellular Pathobiology
    PP2A-B55β Antagonizes Cyclin E1 Proteolysis and Promotes Its Dysregulation in Cancer
    YingMeei Tan, Dahui Sun, Weijian Jiang, Kathleen Klotz-Noack, Ajay A. Vashisht, James Wohlschlegel, Martin Widschwendter and Charles Spruck
    Cancer Res April 1 2014 74 (7) 2006-2014; DOI:10.1158/0008-5472.CAN-13-1263

    As a candidate therapeutic target, overexpressed cyclin E1 is a driving force of hormone-independent growth, genetic instability, and progression of “triple-negative” breast cancers and other aggressive cancers.

  • Molecular and Cellular Pathobiology
    LRH-1 Governs Vital Transcriptional Programs in Endocrine-Sensitive and -Resistant Breast Cancer Cells
    Stéphanie Bianco, Mylène Brunelle, Maïka Jangal, Luca Magnani and Nicolas Gévry
    Cancer Res April 1 2014 74 (7) 2015-2025; DOI:10.1158/0008-5472.CAN-13-2351

    This study shows how the nuclear receptor LRH-1 modulates the sensitivity of breast cancer cells to antiestrogen therapy, suggesting new insights into how resistance may emerge to limit treatment effectiveness.

  • Molecular and Cellular Pathobiology
    Latency-Associated Nuclear Antigen of Kaposi Sarcoma–Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1
    Xing Wang, Zhiheng He, Tian Xia, Xiaofan Li, Deguang Liang, Xianzhi Lin, Hao Wen and Ke Lan
    Cancer Res April 1 2014 74 (7) 2026-2037; DOI:10.1158/0008-5472.CAN-13-1467

    These findings identify a therapeutic target for treatment of Kaposi sarcoma, a cancer best known for its association with AIDS patients at highest risk of this herpesvirus-driven disease.

  • Molecular and Cellular Pathobiology
    Tumor-Infiltrating Myeloid Cells Activate Dll4/Notch/TGF-β Signaling to Drive Malignant Progression
    Hidetaka Ohnuki, Kan Jiang, Dunrui Wang, Ombretta Salvucci, Hyeongil Kwak, David Sánchez-Martín, Dragan Maric and Giovanna Tosato
    Cancer Res April 1 2014 74 (7) 2038-2049; DOI:10.1158/0008-5472.CAN-13-3118

    This study describes a myeloid cell–carcinoma signaling network that links the tumor microenvironment in new ways with tumor growth, highlighting opportunities to target tumors where this network is active.

Therapeutics, Targets, and Chemical Biology

  • Therapeutics, Targets, and Chemical Biology
    CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy
    Liya Ding, Shuai Chen, Ping Liu, Yunqian Pan, Jian Zhong, Kevin M. Regan, Liguo Wang, Chunrong Yu, Anthony Rizzardi, Liang Cheng, Jun Zhang, Stephen C. Schmechel, John C. Cheville, Jan Van Deursen, Donald J. Tindall and Haojie Huang
    Cancer Res April 1 2014 74 (7) 2050-2061; DOI:10.1158/0008-5472.CAN-13-1659

    These results suggest new insights into prostate cancer etiology, establishing a central role for histone modification and providing a rationale for clinical evaluation of epigenetic-targeted therapy in prostate cancer patients.

  • Therapeutics, Targets, and Chemical Biology | AuthorChoice
    Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
    Nagaraj S. Nagathihalli, Yugandhar Beesetty, Wooin Lee, M. Kay Washington, Xi Chen, A. Craig Lockhart and Nipun B. Merchant
    Cancer Res April 1 2014 74 (7) 2062-2072; DOI:10.1158/0008-5472.CAN-13-2329

    These findings define an EGF-related signaling pathway that mediates the oncogenic effects of secondary bile acids in gastrointestinal cancers, the targeting of which may enhance therapeutic responses.

  • Therapeutics, Targets, and Chemical Biology
    Bioluminescent Imaging of HPV-Positive Oral Tumor Growth and Its Response to Image-Guided Radiotherapy
    Rong Zhong, Matt Pytynia, Charles Pelizzari and Michael Spiotto
    Cancer Res April 1 2014 74 (7) 2073-2081; DOI:10.1158/0008-5472.CAN-13-2993

    More rapid visualization of HPV-positive oral tumor growth will assist the development of chemotherapeutic and radiotherapeutic strategies to stem this rapidly growing disease.

Tumor and Stem Cell Biology

  • Tumor and Stem Cell Biology
    Small GTPase RhoE/Rnd3 Is a Critical Regulator of Notch1 Signaling
    Zehua Zhu, Kristina Todorova, Kevin K. Lee, Jun Wang, Eunjeong Kwon, Ivan Kehayov, Hyung-Gu Kim, Vihren Kolev, G. Paolo Dotto, Sam W. Lee and Anna Mandinova
    Cancer Res April 1 2014 74 (7) 2082-2093; DOI:10.1158/0008-5472.CAN-12-0452

    These findings describe an important regulatory feedback on a key tumor suppressor pathway that may have a pivotal role in epithelial tumors.

  • Tumor and Stem Cell Biology
    Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication
    David C. de Leeuw, Fedor Denkers, Marjolein C. Olthof, Arjo P. Rutten, Walter Pouwels, Gerrit Jan Schuurhuis, Gert J. Ossenkoppele and Linda Smit
    Cancer Res April 1 2014 74 (7) 2094-2105; DOI:10.1158/0008-5472.CAN-13-1733

    These findings define miR-126 as a therapeutic focus to specifically eradicate stem-like cells in acute myeloid leukemias that tend to relapse in patients despite early positive responses to chemotherapy.

  • Tumor and Stem Cell Biology
    NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells
    Anna Pastò, Valentina Serafin, Giorgia Pilotto, Claudia Lago, Chiara Bellio, Livio Trusolino, Andrea Bertotti, Timothy Hoey, Michelina Plateroti, Giovanni Esposito, Marica Pinazza, Marco Agostini, Donato Nitti, Alberto Amadori and Stefano Indraccolo
    Cancer Res April 1 2014 74 (7) 2106-2118; DOI:10.1158/0008-5472.CAN-13-2022

    These findings point to a specific inhibition of NOTCH2/3, rather than NOTCH1, as a strategy for attacking cancer stem-like cells in metastatic colon cancer.

  • Tumor and Stem Cell Biology
    shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
    Tao Deng, Jeff C. Liu, Philip E.D. Chung, David Uehling, Ahmed Aman, Babu Joseph, Troy Ketela, Zhe Jiang, Nathan F. Schachter, Robert Rottapel, Sean E. Egan, Rima Al-awar, Jason Moffat and Eldad Zacksenhaus
    Cancer Res April 1 2014 74 (7) 2119-2130; DOI:10.1158/0008-5472.CAN-13-2138

    These results identify a novel target to improve treatment of HER2-positive breast cancer through leveraging existing anti-HER2 therapy.

Correction

  • Correction
    Correction: Epithelial Junction Opener JO-1 Improves Monoclonal Antibody Therapy of Cancer
    Cancer Res April 1 2014 74 (7) 2131-2131; DOI:10.1158/0008-5472.CAN-14-0557

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Cancer Research: 74 (7)
April 2014
Volume 74, Issue 7
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Issue Highlights

  • Vaccine-Mediated Immunotherapy Directed against a Transcription Factor Driving the Metastatic Process
  • VISTA Is an Immune Checkpoint Molecule for Human T Cells
  • VISTA Regulates the Development of Protective Antitumor Immunity

Jump to

  • Breaking Advances
  • Reviews
  • Priority Report
  • Integrated Systems and Technologies
  • Microenvironment and Immunology
  • Molecular and Cellular Pathobiology
  • Therapeutics, Targets, and Chemical Biology
  • Tumor and Stem Cell Biology
  • Correction
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  • Towards Multidrug Adaptive Therapy
  • MEK Inhibition Synergizes with Statins for Cancer Treatment
  • IL1β Promotes Immune Suppression in Pancreatic Cancer
  • Multiple Primary Cancer Penetrance for TP53
  • Metabolomic Gradients in Glioblastoma Models
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Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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