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Cancer Research
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About the Cover

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In normal epithelial cells, there is a balance of pro- and antiangiogenic and lymphangiogenic factors maintaining proper tissue homeostasis. During malignant transformation, early loss of one such factor, the lymphatic endothelial cell inhibitor SEMA3F, is necessary to enable pathologic lymphangiogenesis. As the squamous cell carcinoma cells develop a more aggressive phenotype, acquired expression of surface receptors like neuropilin 2 (NRP2), a receptor typically expressed at high levels on lymphatic endothelial cells, further facilitate tumor vascularity, expansion, and metastatic spread. Thus, expression of SEMA3F may function in both an autocrine and paracrine fashion through NRP2 to inhibit tumor growth, lymphatic invasion, and metastasis. For details, see article by Doçi and colleagues on page 2937.

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Cancer Research: 75 (14)
July 2015
Volume 75, Issue 14
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Issue Highlights

  • Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma
  • Enhanced MET Translation and Signaling Sustains K-Ras–Driven Proliferation under Anchorage-Independent Growth Conditions
  • Evidence Suggesting That Discontinuous Dosing of ALK Kinase Inhibitors May Prolong Control of ALK+ Tumors
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Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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