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Therapeutics, Targets, and Chemical Biology

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

Eli M. Wallace, James P. Rizzi, Guangzhou Han, Paul M. Wehn, Zhaodan Cao, Xinlin Du, Tzuling Cheng, Robert M. Czerwinski, Darryl D. Dixon, Barry S. Goggin, Jonas A. Grina, Megan M. Halfmann, Melissa A. Maddie, Sarah R. Olive, Stephen T. Schlachter, Huiling Tan, Bin Wang, Keshi Wang, Shanhai Xie, Rui Xu, Hanbiao Yang and John A. Josey
Eli M. Wallace
Peloton Therapeutics, Inc., Dallas, Texas.
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  • For correspondence: eli.wallace@pelotontx.com
James P. Rizzi
Peloton Therapeutics, Inc., Dallas, Texas.
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Guangzhou Han
Peloton Therapeutics, Inc., Dallas, Texas.
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Paul M. Wehn
Peloton Therapeutics, Inc., Dallas, Texas.
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Zhaodan Cao
Peloton Therapeutics, Inc., Dallas, Texas.
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Xinlin Du
Peloton Therapeutics, Inc., Dallas, Texas.
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Tzuling Cheng
Peloton Therapeutics, Inc., Dallas, Texas.
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Robert M. Czerwinski
Peloton Therapeutics, Inc., Dallas, Texas.
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Darryl D. Dixon
Peloton Therapeutics, Inc., Dallas, Texas.
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Barry S. Goggin
Peloton Therapeutics, Inc., Dallas, Texas.
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Jonas A. Grina
Peloton Therapeutics, Inc., Dallas, Texas.
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Megan M. Halfmann
Peloton Therapeutics, Inc., Dallas, Texas.
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Melissa A. Maddie
Peloton Therapeutics, Inc., Dallas, Texas.
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Sarah R. Olive
Peloton Therapeutics, Inc., Dallas, Texas.
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Stephen T. Schlachter
Peloton Therapeutics, Inc., Dallas, Texas.
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Huiling Tan
Peloton Therapeutics, Inc., Dallas, Texas.
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Bin Wang
Peloton Therapeutics, Inc., Dallas, Texas.
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Keshi Wang
Peloton Therapeutics, Inc., Dallas, Texas.
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Shanhai Xie
Peloton Therapeutics, Inc., Dallas, Texas.
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Rui Xu
Peloton Therapeutics, Inc., Dallas, Texas.
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Hanbiao Yang
Peloton Therapeutics, Inc., Dallas, Texas.
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John A. Josey
Peloton Therapeutics, Inc., Dallas, Texas.
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DOI: 10.1158/0008-5472.CAN-16-0473 Published September 2016
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Cited By

Article Information

Volume 76, Issue 18, pp. 5491-5500

DOI 
https://doi.org/10.1158/0008-5472.CAN-16-0473
PubMed 
27635045

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received February 22, 2016
  • Revision received June 19, 2016
  • Accepted July 6, 2016
  • Published first September 6, 2016.

Article Versions

  • Previous version (September 6, 2016 - 12:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. Eli M. Wallace*,
  2. James P. Rizzi,
  3. Guangzhou Han,
  4. Paul M. Wehn,
  5. Zhaodan Cao,
  6. Xinlin Du,
  7. Tzuling Cheng,
  8. Robert M. Czerwinski,
  9. Darryl D. Dixon,
  10. Barry S. Goggin,
  11. Jonas A. Grina,
  12. Megan M. Halfmann,
  13. Melissa A. Maddie,
  14. Sarah R. Olive,
  15. Stephen T. Schlachter,
  16. Huiling Tan,
  17. Bin Wang,
  18. Keshi Wang,
  19. Shanhai Xie,
  20. Rui Xu,
  21. Hanbiao Yang, and
  22. John A. Josey
  1. Peloton Therapeutics, Inc., Dallas, Texas.
  1. ↵*Corresponding Author:
    Eli M. Wallace, Peloton Therapeutics Inc., 2330 Inwood Road, Suite 226, Dallas, TX 75235. Phone: 972-629-4126; Fax: 972-629-4111; E-mail: eli.wallace{at}pelotontx.com
  • Current address for D.D. Dixon: Bristol-Myers Squibb, New Brunswick, New Jersey; current address for M.M. Halfmann: Stowers Institute for Medical Research, Kansas City, Missouri; current address for M.A. Maddie: Renovo Neural, Inc., Cleveland, Ohio; and current address for S.R. Olive: Progen Lab, Dallas, Texas.

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Cancer Research: 76 (18)
September 2016
Volume 76, Issue 18
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A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
Eli M. Wallace, James P. Rizzi, Guangzhou Han, Paul M. Wehn, Zhaodan Cao, Xinlin Du, Tzuling Cheng, Robert M. Czerwinski, Darryl D. Dixon, Barry S. Goggin, Jonas A. Grina, Megan M. Halfmann, Melissa A. Maddie, Sarah R. Olive, Stephen T. Schlachter, Huiling Tan, Bin Wang, Keshi Wang, Shanhai Xie, Rui Xu, Hanbiao Yang and John A. Josey
Cancer Res September 15 2016 (76) (18) 5491-5500; DOI: 10.1158/0008-5472.CAN-16-0473

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A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
Eli M. Wallace, James P. Rizzi, Guangzhou Han, Paul M. Wehn, Zhaodan Cao, Xinlin Du, Tzuling Cheng, Robert M. Czerwinski, Darryl D. Dixon, Barry S. Goggin, Jonas A. Grina, Megan M. Halfmann, Melissa A. Maddie, Sarah R. Olive, Stephen T. Schlachter, Huiling Tan, Bin Wang, Keshi Wang, Shanhai Xie, Rui Xu, Hanbiao Yang and John A. Josey
Cancer Res September 15 2016 (76) (18) 5491-5500; DOI: 10.1158/0008-5472.CAN-16-0473
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