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Integrated Systems and Technologies

Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type–Specific Dynamic Logic Models

Federica Eduati, Victoria Doldàn-Martelli, Bertram Klinger, Thomas Cokelaer, Anja Sieber, Fiona Kogera, Mathurin Dorel, Mathew J. Garnett, Nils Blüthgen and Julio Saez-Rodriguez
Federica Eduati
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.
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Victoria Doldàn-Martelli
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.
2Departamento de Física de la Materia Condensada, Condensed Matter Physics Center (IFIMAC) and Instituto Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
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Bertram Klinger
3Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
4Integrative Research Institute (IRI) Life Sciences and Institute for Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
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Thomas Cokelaer
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.
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Anja Sieber
3Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
4Integrative Research Institute (IRI) Life Sciences and Institute for Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
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Fiona Kogera
5Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
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Mathurin Dorel
3Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
4Integrative Research Institute (IRI) Life Sciences and Institute for Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
6Berlin Institute of Health (BIH), Berlin, Germany.
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Mathew J. Garnett
5Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
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Nils Blüthgen
3Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
4Integrative Research Institute (IRI) Life Sciences and Institute for Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
6Berlin Institute of Health (BIH), Berlin, Germany.
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  • For correspondence: saezrodriguez@gmail.com nils.bluethgen@charite.de
Julio Saez-Rodriguez
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.
7Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Faculty of Medicine, Aachen, Germany.
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  • For correspondence: saezrodriguez@gmail.com nils.bluethgen@charite.de
DOI: 10.1158/0008-5472.CAN-17-0078 Published June 2017
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Total538842563466

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Article Information

Volume 77, Issue 12, pp. 3364-3375

DOI 
https://doi.org/10.1158/0008-5472.CAN-17-0078
PubMed 
28381545

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received January 10, 2017
  • Revision received March 17, 2017
  • Accepted March 31, 2017
  • Published first April 5, 2017.

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  • Previous version (April 5, 2017 - 14:22).
  • Previous version (June 5, 2017 - 07:21).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Federica Eduati1,
  2. Victoria Doldàn-Martelli1,2,
  3. Bertram Klinger3,4,
  4. Thomas Cokelaer1,
  5. Anja Sieber3,4,
  6. Fiona Kogera5,
  7. Mathurin Dorel3,4,6,
  8. Mathew J. Garnett5,
  9. Nils Blüthgen3,4,6,*, and
  10. Julio Saez-Rodriguez1,7,*
  1. 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom.
  2. 2Departamento de Física de la Materia Condensada, Condensed Matter Physics Center (IFIMAC) and Instituto Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
  3. 3Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  4. 4Integrative Research Institute (IRI) Life Sciences and Institute for Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
  5. 5Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
  6. 6Berlin Institute of Health (BIH), Berlin, Germany.
  7. 7Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Faculty of Medicine, Aachen, Germany.
  1. ↵*Corresponding Authors:
    Julio Saez-Rodriguez, MTZ, Pauwelsstr 19, D-52074 Aachen, Germany. Phone: 49-2418089-337; Fax: 49-0241-80-82189; E-mail: saezrodriguez{at}gmail.com; and Nils Blüthgen, Institute of Pathology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin. Phone: 49-30-2093-92390; E-mail: nils.bluethgen{at}charite.de
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Cancer Research: 77 (12)
June 2017
Volume 77, Issue 12
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Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type–Specific Dynamic Logic Models
Federica Eduati, Victoria Doldàn-Martelli, Bertram Klinger, Thomas Cokelaer, Anja Sieber, Fiona Kogera, Mathurin Dorel, Mathew J. Garnett, Nils Blüthgen and Julio Saez-Rodriguez
Cancer Res June 15 2017 (77) (12) 3364-3375; DOI: 10.1158/0008-5472.CAN-17-0078

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Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type–Specific Dynamic Logic Models
Federica Eduati, Victoria Doldàn-Martelli, Bertram Klinger, Thomas Cokelaer, Anja Sieber, Fiona Kogera, Mathurin Dorel, Mathew J. Garnett, Nils Blüthgen and Julio Saez-Rodriguez
Cancer Res June 15 2017 (77) (12) 3364-3375; DOI: 10.1158/0008-5472.CAN-17-0078
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