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Integrated Systems and Technologies

Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy

Michael Jermyn, Jeanne Mercier, Kelly Aubertin, Joannie Desroches, Kirk Urmey, Jason Karamchandiani, Eric Marple, Marie-Christine Guiot, Frederic Leblond and Kevin Petrecca
Michael Jermyn
1Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
2Department of Engineering Physics, Polytechnique Montreal, Montreal, Quebec, Canada.
3Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire.
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Jeanne Mercier
2Department of Engineering Physics, Polytechnique Montreal, Montreal, Quebec, Canada.
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Kelly Aubertin
2Department of Engineering Physics, Polytechnique Montreal, Montreal, Quebec, Canada.
4Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Quebec, Canada.
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Joannie Desroches
2Department of Engineering Physics, Polytechnique Montreal, Montreal, Quebec, Canada.
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Kirk Urmey
5EMVision LLC, Loxahatchee, Florida.
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Jason Karamchandiani
6Division of Neuropathology, Department of Pathology, McGill University, Montreal, Quebec, Canada.
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Eric Marple
5EMVision LLC, Loxahatchee, Florida.
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Marie-Christine Guiot
6Division of Neuropathology, Department of Pathology, McGill University, Montreal, Quebec, Canada.
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Frederic Leblond
2Department of Engineering Physics, Polytechnique Montreal, Montreal, Quebec, Canada.
4Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Quebec, Canada.
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  • For correspondence: Frederic.Leblond@polymtl.ca Kevin.Petrecca@mcgill.ca
Kevin Petrecca
1Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
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  • For correspondence: Frederic.Leblond@polymtl.ca Kevin.Petrecca@mcgill.ca
DOI: 10.1158/0008-5472.CAN-17-0668 Published July 2017
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Abstract

Effectiveness of surgery as a cancer treatment is reduced when all cancer cells are not detected during surgery, leading to recurrences that negatively impact survival. To maximize cancer cell detection during cancer surgery, we designed an in situ intraoperative, label-free, optical cancer detection system that combines intrinsic fluorescence spectroscopy, diffuse reflectance spectroscopy, and Raman spectroscopy. Using this multimodal optical cancer detection system, we found that brain, lung, colon, and skin cancers could be detected in situ during surgery with an accuracy, sensitivity, and specificity of 97%, 100%, and 93%, respectively. This highly sensitive optical molecular imaging approach can profoundly impact a wide range of surgical and noninvasive interventional oncology procedures by improving cancer detection capabilities, thereby reducing cancer burden and improving survival and quality of life. Cancer Res; 77(14); 3942–50. ©2017 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Research Online (http://cancerres.aacrjournals.org/).

  • Received March 5, 2017.
  • Revision received April 11, 2017.
  • Accepted April 27, 2017.
  • ©2017 American Association for Cancer Research.
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Cancer Research: 77 (14)
July 2017
Volume 77, Issue 14
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Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy
Michael Jermyn, Jeanne Mercier, Kelly Aubertin, Joannie Desroches, Kirk Urmey, Jason Karamchandiani, Eric Marple, Marie-Christine Guiot, Frederic Leblond and Kevin Petrecca
Cancer Res July 15 2017 (77) (14) 3942-3950; DOI: 10.1158/0008-5472.CAN-17-0668

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Highly Accurate Detection of Cancer In Situ with Intraoperative, Label-Free, Multimodal Optical Spectroscopy
Michael Jermyn, Jeanne Mercier, Kelly Aubertin, Joannie Desroches, Kirk Urmey, Jason Karamchandiani, Eric Marple, Marie-Christine Guiot, Frederic Leblond and Kevin Petrecca
Cancer Res July 15 2017 (77) (14) 3942-3950; DOI: 10.1158/0008-5472.CAN-17-0668
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