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Cancer Research
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About the Cover

Cover image

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DNA topoisomerase IIa (Topo IIa) plays a pivotal role in chromatin organization and unaltered chromosome inheritance. Moreover, Topo IIa is a core target of several anticancer drugs. Smurf2, an E3 ubiquitin ligase and suggested tumor suppressor, acts as a key cellular factor that directly binds and stabilizes Topo IIa and prevents the formation of pathological chromatin bridges. The image shows molecular biodistribution of Smurf2 and Topo IIa in human interphase and mitotic cells. For details, see article by Emanuelli and colleagues on page 4217.

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Cancer Research: 77 (16)
August 2017
Volume 77, Issue 16
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Issue Highlights

  • Smurf2-Mediated Stabilization of DNA Topoisomerase IIα Controls Genomic Integrity
  • Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell–Mediated Immunotherapy
  • Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells
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Copyright © 2021 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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