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Table of Contents

Focus on Computer Resources

Breaking Advances

Reviews

Perspective

Meeting Report

  • Meeting Report | AuthorChoice
    Moonshot Acceleration Factor: Medical Imaging
    Eva M. Sevick-Muraca, Richard A. Frank, Maryellen L. Giger and James L. Mulshine
    Cancer Res November 1 2017 77 (21) 5717-5720; DOI:10.1158/0008-5472.CAN-17-1698

Priority Report

  • Priority Report
    Discovery of Human-Similar Gene Fusions in Canine Cancers
    Ronan Ulvé, Mélanie Rault, Mathieu Bahin, Laetitia Lagoutte, Jérôme Abadie, Clotilde De Brito, Jean-Michel Coindre, Nadine Botherel, Audrey Rousseau, Valentin Wucher, Edouard Cadieu, Catherine Thieblemont, Christophe Hitte, Laurence Cornevin, Florian Cabillic, Laura Bachelot, David Gilot, Benoit Hennuy, Thierry Guillaudeux, Arnaud Le Goff, Thomas Derrien, Benoît Hédan and Catherine André
    Cancer Res November 1 2017 77 (21) 5721-5727; DOI:10.1158/0008-5472.CAN-16-2691

    These findings highlight the utility of integrating spontaneous dog models of cancer in preclinical trials to evaluate targeted therapies.

Molecular and Cellular Pathobiology

  • Molecular and Cellular Pathobiology
    miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells
    Ying Z. Mazzu, Yulan Hu, Rajesh K. Soni, Kelly M. Mojica, Li-Xuan Qin, Phaedra Agius, Zachary M. Waxman, Aleksandra Mihailovic, Nicholas D. Socci, Ronald C. Hendrickson, Thomas Tuschl and Samuel Singer
    Cancer Res November 1 2017 77 (21) 5728-5740; DOI:10.1158/0008-5472.CAN-16-2253

    These mechanistic findings reveal critical tyrosine kinase andDNA methylation pathways in liposarcoma, some with immediate implications for therapeutic exploration.

  • Molecular and Cellular Pathobiology
    Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
    Ches'Nique M. Phillips, John R. Zatarain, Michael E. Nicholls, Craig Porter, Steve G. Widen, Ketan Thanki, Paul Johnson, Muhammad U. Jawad, Mary P. Moyer, James W. Randall, Judith L. Hellmich, Manjit Maskey, Suimin Qiu, Thomas G. Wood, Nadiya Druzhyna, Bartosz Szczesny, Katalin Módis, Csaba Szabo, Celia Chao and Mark R. Hellmich
    Cancer Res November 1 2017 77 (21) 5741-5754; DOI:10.1158/0008-5472.CAN-16-3480

    These findings suggest that efforts to limit transsulfuration pathways that upregulate H2S production may have preventive benefits in limiting colorectal cancer.

  • Molecular and Cellular Pathobiology
    PADI2-Mediated Citrullination Promotes Prostate Cancer Progression
    Lin Wang, Guanhua Song, Xiang Zhang, Tingting Feng, Jihong Pan, Weiwen Chen, Muyi Yang, Xinnuo Bai, Yu Pang, Jindan Yu, Jinxiang Han and Bo Han
    Cancer Res November 1 2017 77 (21) 5755-5768; DOI:10.1158/0008-5472.CAN-17-0150

    This study reveals protein citrullination, a unique type of protein modification, as a novel pathogenic contributor to advanced prostate cancer, with immediate implications for its potential treatment given the opportunity to reposition modalities currently in clinical development for arthritis therapy.

  • Molecular and Cellular Pathobiology
    YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63–GPX2 Axis and ROS Accumulation
    Hsinyi Huang, Wenjing Zhang, Yafang Pan, Yijun Gao, Lei Deng, Fuming Li, Fei Li, Xueyan Ma, Shenda Hou, Jing Xu, Peixue Li, Xiaoxun Li, Guohong Hu, Cheng Li, Haiquan Chen, Lei Zhang and Hongbin Ji
    Cancer Res November 1 2017 77 (21) 5769-5781; DOI:10.1158/0008-5472.CAN-17-0449

    These findings indicate that the transcription factor YAP, a classic oncogene in lung adenocarcinoma, acts as a tumor suppressor in lung squamous cell carcinoma.

  • Molecular and Cellular Pathobiology
    MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway
    Tao Yu, Yingjun Zhao, Zhixiang Hu, Jing Li, Dandan Chu, Jiwei Zhang, Zhe Li, Bing Chen, Xiao Zhang, Hongyu Pan, Shengli Li, Hechun Lin, Lei Liu, Mingxia Yan, Xianghuo He and Ming Yao
    Cancer Res November 1 2017 77 (21) 5782-5794; DOI:10.1158/0008-5472.CAN-17-0671

    These results establish the long noncoding RNA MetaLnc9 as a driver of metastasis and a candidate therapeutic target for treating advanced NSCLC.

  • Molecular and Cellular Pathobiology
    Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation
    Laura E. Jackson, Sucheta Kulkarni, Huabo Wang, Jie Lu, James M. Dolezal, Sivakama S. Bharathi, Sarangarajan Ranganathan, Mulchand S. Patel, Rahul Deshpande, Frances Alencastro, Stacy G. Wendell, Eric S. Goetzman, Andrew W. Duncan and Edward V. Prochownik
    Cancer Res November 1 2017 77 (21) 5795-5807; DOI:10.1158/0008-5472.CAN-17-1325

    These striking findings show that the pyruvate dehydrogenase complex, which biochemically links glycolysis to the TCA cycle, can be completely eliminated without significantly affecting normal or neoplastic proliferation.

Tumor and Stem Cell Biology

  • Tumor and Stem Cell Biology
    Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587
    Javier Figueroa, Lynette M. Phillips, Tal Shahar, Anwar Hossain, Joy Gumin, Hoon Kim, Andrew J. Bean, George A. Calin, Juan Fueyo, Edgar T. Walters, Raghu Kalluri, Roel G. Verhaak and Frederick F. Lang
    Cancer Res November 1 2017 77 (21) 5808-5819; DOI:10.1158/0008-5472.CAN-16-2524

    These results illuminate the mechanism through which glioma-associated mesenchymal stem cells enhance the aggressiveness of glioblastoma.

  • Tumor and Stem Cell Biology
    KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling
    James V. Neiswender, Robert L. Kortum, Caitlin Bourque, Melissa Kasheta, Leonard I. Zon, Deborah K. Morrison and Craig J. Ceol
    Cancer Res November 1 2017 77 (21) 5820-5830; DOI:10.1158/0008-5472.CAN-17-0473

    These findings establish that KIT exerts a negative modifier role in melanoma by attenuating BRAFV600E activity.

  • Tumor and Stem Cell Biology
    ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling
    Qian Yan, Lingxi Jiang, Ming Liu, Dandan Yu, Yu Zhang, Yan Li, Shuo Fang, Yan Li, Ying-Hui Zhu, Yun-Fei Yuan and Xin-Yuan Guan
    Cancer Res November 1 2017 77 (21) 5831-5845; DOI:10.1158/0008-5472.CAN-17-0579

    These results suggest a secreted tumor suppressor has the potential to be developed as a novel prognostic biomarker and novel therapeutic target in liver cancer.

  • Tumor and Stem Cell Biology | AuthorChoice
    Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
    Fernando Salvador, Alberto Martin, Celia López-Menéndez, Gema Moreno-Bueno, Vanesa Santos, Alberto Vázquez-Naharro, Patricia G. Santamaria, Saleta Morales, Pierre R. Dubus, Laura Muinelo-Romay, Rafael López-López, Jason C. Tung, Valerie M. Weaver, Francisco Portillo and Amparo Cano
    Cancer Res November 1 2017 77 (21) 5846-5859; DOI:10.1158/0008-5472.CAN-16-3152

    Conditional transgenic mouse models establish a new role for an ECM regulator in metastatic invasion that is independent of its canonical function in ECM remodeling.

  • Tumor and Stem Cell Biology
    Novel SEC61G–EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens
    Tiziana Servidei, Daniela Meco, Valentina Muto, Alessandro Bruselles, Andrea Ciolfi, Nadia Trivieri, Matteo Lucchini, Roberta Morosetti, Massimiliano Mirabella, Maurizio Martini, Massimo Caldarelli, Anna Lasorella, Marco Tartaglia and Riccardo Riccardi
    Cancer Res November 1 2017 77 (21) 5860-5872; DOI:10.1158/0008-5472.CAN-17-0790

    These findings demonstrate how in vitro culture selections applied to genetically heterogenous tumors that occur rarely may help identify focal mutations that are pharmaceutically actionable in rare cancers, as in the case here for ependymoma, a rare cancer of the central nervous system.

  • Tumor and Stem Cell Biology
    ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma
    Abibatou Ndoye, Anna Budina-Kolomets, Curtis H. Kugel III, Marie R. Webster, Amanpreet Kaur, Reeti Behera, Vito W. Rebecca, Ling Li, Patricia A. Brafford, Qin Liu, Y.N. Vashisht Gopal, Michael A. Davies, Gordon B. Mills, Xiaowei Xu, Hong Wu, Meenhard Herlyn, Michael C. Nicastri, Jeffrey D. Winkler, Maria S. Soengas, Ravi K. Amaravadi, Maureen E. Murphy and Ashani T. Weeraratna
    Cancer Res November 1 2017 77 (21) 5873-5885; DOI:10.1158/0008-5472.CAN-17-0907

    Restoring β-catenin activity in Wnt5Ahigh melanoma cells sensitizes them to inhibition by the lysosomotropic agent Lys05, a finding of significance as studies to inhibit autophagy move into the clinic.

  • Tumor and Stem Cell Biology
    FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk
    Marco Chi-Chung Lau, Kai Yu Ng, Tin Lok Wong, Man Tong, Terence K. Lee, Xiao-Yan Ming, Simon Law, Nikki P. Lee, Annie L. Cheung, Yan-Ru Qin, Kwok Wah Chan, Wen Ning, Xin-Yuan Guan and Stephanie Ma
    Cancer Res November 1 2017 77 (21) 5886-5899; DOI:10.1158/0008-5472.CAN-17-1411

    These findings reveal a critical regulator of oncogenesis and metastasis in esophageal squamous cell carcinoma and highlight its potential as a biomarker and therapeutic target.

  • Tumor and Stem Cell Biology | AuthorChoice
    KDM4 Inhibition Targets Breast Cancer Stem–like Cells
    Eric Metzger, Stella S. Stepputtis, Juliane Strietz, Bogdan-Tiberius Preca, Sylvia Urban, Dominica Willmann, Anita Allen, Fides Zenk, Nicola Iovino, Peter Bronsert, Amelie Proske, Marie Follo, Melanie Boerries, Elmar Stickeler, Jiangchun Xu, Michael B. Wallace, Jeffrey A. Stafford, Toufike Kanouni, Jochen Maurer and Roland Schüle
    Cancer Res November 1 2017 77 (21) 5900-5912; DOI:10.1158/0008-5472.CAN-17-1754

    Breast cancer stem-like cells that can recapitulate triple-negative breast tumors were used in this study to help validate therapeutic targets such as the epigenetic regulator KDM4.

Therapeutics, Targets, and Chemical Biology

Microenvironment and Immunology

  • Microenvironment and Immunology
    Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer
    Zenobia D'Costa, Keaton Jones, Abul Azad, Ruud van Stiphout, Su Y. Lim, Ana L. Gomes, Paul Kinchesh, Sean C. Smart, W. Gillies McKenna, Francesca M. Buffa, Owen J. Sansom, Ruth J. Muschel, Eric O'Neill and Emmanouil Fokas
    Cancer Res November 1 2017 77 (21) 5952-5962; DOI:10.1158/0008-5472.CAN-16-2833

    These findings suggest TIMP1 as an appealing therapeutic target in pancreatic cancer, which continues to defy effective treatment.

  • Microenvironment and Immunology
    Enhanced Acid Sphingomyelinase Activity Drives Immune Evasion and Tumor Growth in Non–Small Cell Lung Carcinoma
    Katerina Kachler, Maximilian Bailer, Lisanne Heim, Fabian Schumacher, Martin Reichel, Corinna D. Holzinger, Sonja Trump, Susanne Mittler, Juliana Monti, Denis I. Trufa, Ralf J. Rieker, Arndt Hartmann, Horia Sirbu, Burkhard Kleuser, Johannes Kornhuber and Susetta Finotto
    Cancer Res November 1 2017 77 (21) 5963-5976; DOI:10.1158/0008-5472.CAN-16-3313

    An enzyme that controls membrane composition and dynamics in cancer cells is a potential therapeutic target for immunomodulatory therapy in lung adenocarcinoma.

  • Microenvironment and Immunology
    Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand
    Sang W. Kang, Sang C. Lee, So H. Park, Juyang Kim, Hyeon H. Kim, Hyeon-Woo Lee, Su K. Seo, Byoung S. Kwon, Hong R. Cho and Byungsuk Kwon
    Cancer Res November 1 2017 77 (21) 5989-6000; DOI:10.1158/0008-5472.CAN-17-0610

    This potentially seminal study suggests a nodal role for CD137-CD137L immune signaling in the coordinate control of tumor immunosurveillance, spotlighting CD137L as an attractive intervention point to enhance cancer immunotherapy.

  • Microenvironment and Immunology
    Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques
    Hirohito Ishigaki, Toshinaga Maeda, Hirokazu Inoue, Tsuyoshi Akagi, Takako Sasamura, Hideaki Ishida, Toshiro Inubushi, Junko Okahara, Takashi Shiina, Misako Nakayama, Yasushi Itoh and Kazumasa Ogasawara
    Cancer Res November 1 2017 77 (21) 6001-6010; DOI:10.1158/0008-5472.CAN-17-0775

    These seminal findings show that adequate immune surveillance depends vitally on the generation of cancer-specific antibodies.

Integrated Systems and Technologies

  • Integrated Systems and Technologies
    Optical Coherence Tomography Detects Necrotic Regions and Volumetrically Quantifies Multicellular Tumor Spheroids
    Yongyang Huang, Shunqiang Wang, Qiongyu Guo, Sarah Kessel, Ian Rubinoff, Leo Li-Ying Chan, Peter Li, Yaling Liu, Jean Qiu and Chao Zhou
    Cancer Res November 1 2017 77 (21) 6011-6020; DOI:10.1158/0008-5472.CAN-17-0821

    These findings introduce a label-free imaging technology capable of performing live, longitudinal analysis of 3D tumor spheroids for high-throughput screening of anticancer drugs.

  • Integrated Systems and Technologies
    Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy
    Yang Zhao, Chenran Zhang, Liquan Gao, Xinhe Yu, Jianhao Lai, Dehua Lu, Rui Bao, Yanpu Wang, Bing Jia, Fan Wang and Zhaofei Liu
    Cancer Res November 1 2017 77 (21) 6021-6032; DOI:10.1158/0008-5472.CAN-17-1655

    Photodynamic therapy after chemotherapy is a promising cancer treatment strategy, with macrophage-specific molecular imaging an important potential aid in the rational design of combination therapies.

Prevention and Epidemiology

Letter to the Editor

Corrections

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