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Table of Contents

Focus on Computer Resources

  • Focus on Computer Resources | Free Article
    Cancer Informatics: New Tools for a Data-Driven Age in Cancer Research
    Warren Kibbe, Juli Klemm and John Quackenbush
    Cancer Res November 1 2017 77 (21) e1-e2; DOI:10.1158/0008-5472.CAN-17-2212

  • Focus on Computer Resources | Free Article
    The Cancer Genomics Cloud: Collaborative, Reproducible, and Democratized—A New Paradigm in Large-Scale Computational Research
    Jessica W. Lau, Erik Lehnert, Anurag Sethi, Raunaq Malhotra, Gaurav Kaushik, Zeynep Onder, Nick Groves-Kirkby, Aleksandar Mihajlovic, Jack DiGiovanna, Mladen Srdic, Dragan Bajcic, Jelena Radenkovic, Vladimir Mladenovic, Damir Krstanovic, Vladan Arsenijevic, Djordje Klisic, Milan Mitrovic, Igor Bogicevic, Deniz Kural and Brandi Davis-Dusenbery; for The Seven Bridges CGC Team
    Cancer Res November 1 2017 77 (21) e3-e6; DOI:10.1158/0008-5472.CAN-17-0387

  • Focus on Computer Resources | Free Article
    The ISB Cancer Genomics Cloud: A Flexible Cloud-Based Platform for Cancer Genomics Research
    Sheila M. Reynolds, Michael Miller, Phyliss Lee, Kalle Leinonen, Suzanne M. Paquette, Zack Rodebaugh, Abigail Hahn, David L. Gibbs, Joseph Slagel, William J. Longabaugh, Varsha Dhankani, Madelyn Reyes, Todd Pihl, Mark Backus, Matthew Bookman, Nicole Deflaux, Jonathan Bingham, David Pot and Ilya Shmulevich
    Cancer Res November 1 2017 77 (21) e7-e10; DOI:10.1158/0008-5472.CAN-17-0617

  • Focus on Computer Resources | Free Article
    WebMeV: A Cloud Platform for Analyzing and Visualizing Cancer Genomic Data
    Yaoyu E. Wang, Lev Kutnetsov, Antony Partensky, Jalil Farid and John Quackenbush
    Cancer Res November 1 2017 77 (21) e11-e14; DOI:10.1158/0008-5472.CAN-17-0802

  • Focus on Computer Resources | Free Article
    Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API
    Shane Wilson, Michael Fitzsimons, Martin Ferguson, Allison Heath, Mark Jensen, Josh Miller, Mark W. Murphy, James Porter, Himanso Sahni, Louis Staudt, Yajing Tang, Zhining Wang, Christine Yu, Junjun Zhang, Vincent Ferretti and Robert L. Grossman; for the GDC Project
    Cancer Res November 1 2017 77 (21) e15-e18; DOI:10.1158/0008-5472.CAN-17-0598

  • Focus on Computer Resources | Free Article
    Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer
    Shenglin Mei, Clifford A. Meyer, Rongbin Zheng, Qian Qin, Qiu Wu, Peng Jiang, Bo Li, Xiaohui Shi, Binbin Wang, Jingyu Fan, Celina Shih, Myles Brown, Chongzhi Zang and X. Shirley Liu
    Cancer Res November 1 2017 77 (21) e19-e22; DOI:10.1158/0008-5472.CAN-17-0327

  • Focus on Computer Resources | Free Article
    A Galaxy Implementation of Next-Generation Clustered Heatmaps for Interactive Exploration of Molecular Profiling Data
    Bradley M. Broom, Michael C. Ryan, Robert E. Brown, Futa Ikeda, Mark Stucky, David W. Kane, James Melott, Chris Wakefield, Tod D. Casasent, Rehan Akbani and John N. Weinstein
    Cancer Res November 1 2017 77 (21) e23-e26; DOI:10.1158/0008-5472.CAN-17-0318

  • Focus on Computer Resources | Free Article
    Integrating DNA Methylation and Hydroxymethylation Data with the Mint Pipeline
    Raymond G. Cavalcante, Snehal Patil, Yongseok Park, Laura S. Rozek and Maureen A. Sartor
    Cancer Res November 1 2017 77 (21) e27-e30; DOI:10.1158/0008-5472.CAN-17-0330

  • Focus on Computer Resources | Free Article
    Variant Review with the Integrative Genomics Viewer
    James T. Robinson, Helga Thorvaldsdóttir, Aaron M. Wenger, Ahmet Zehir and Jill P. Mesirov
    Cancer Res November 1 2017 77 (21) e31-e34; DOI:10.1158/0008-5472.CAN-17-0337

  • Focus on Computer Resources | Free Article
    CRAVAT 4: Cancer-Related Analysis of Variants Toolkit
    David L. Masica, Christopher Douville, Collin Tokheim, Rohit Bhattacharya, RyangGuk Kim, Kyle Moad, Michael C. Ryan and Rachel Karchin
    Cancer Res November 1 2017 77 (21) e35-e38; DOI:10.1158/0008-5472.CAN-17-0338

  • Focus on Computer Resources | Free Article
    Software for the Integration of Multiomics Experiments in Bioconductor
    Marcel Ramos, Lucas Schiffer, Angela Re, Rimsha Azhar, Azfar Basunia, Carmen Rodriguez, Tiffany Chan, Phil Chapman, Sean R. Davis, David Gomez-Cabrero, Aedin C. Culhane, Benjamin Haibe-Kains, Kasper D. Hansen, Hanish Kodali, Marie S. Louis, Arvind S. Mer, Markus Riester, Martin Morgan, Vince Carey and Levi Waldron
    Cancer Res November 1 2017 77 (21) e39-e42; DOI:10.1158/0008-5472.CAN-17-0344

  • Focus on Computer Resources | Free Article
    An Accessible Proteogenomics Informatics Resource for Cancer Researchers
    Matthew C. Chambers, Pratik D. Jagtap, James E. Johnson, Thomas McGowan, Praveen Kumar, Getiria Onsongo, Candace R. Guerrero, Harald Barsnes, Marc Vaudel, Lennart Martens, Björn Grüning, Ira R. Cooke, Mohammad Heydarian, Karen L. Reddy and Timothy J. Griffin
    Cancer Res November 1 2017 77 (21) e43-e46; DOI:10.1158/0008-5472.CAN-17-0331

  • Focus on Computer Resources | Free Article
    P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
    Bobbie-Jo M. Webb-Robertson, Lisa M. Bramer, Jeffrey L. Jensen, Markus A. Kobold, Kelly G. Stratton, Amanda M. White and Karin D. Rodland
    Cancer Res November 1 2017 77 (21) e47-e50; DOI:10.1158/0008-5472.CAN-17-0335

  • Focus on Computer Resources | Free Article
    Explore, Visualize, and Analyze Functional Cancer Proteomic Data Using the Cancer Proteome Atlas
    Jun Li, Rehan Akbani, Wei Zhao, Yiling Lu, John N. Weinstein, Gordon B. Mills and Han Liang
    Cancer Res November 1 2017 77 (21) e51-e54; DOI:10.1158/0008-5472.CAN-17-0369

  • Focus on Computer Resources | Free Article
    DINC 2.0: A New Protein–Peptide Docking Webserver Using an Incremental Approach
    Dinler A. Antunes, Mark Moll, Didier Devaurs, Kyle R. Jackson, Gregory Lizée and Lydia E. Kavraki
    Cancer Res November 1 2017 77 (21) e55-e57; DOI:10.1158/0008-5472.CAN-17-0511

  • Focus on Computer Resources | Free Article
    NDEx 2.0: A Clearinghouse for Research on Cancer Pathways
    Dexter Pratt, Jing Chen, Rudolf Pillich, Vladimir Rynkov, Aaron Gary, Barry Demchak and Trey Ideker
    Cancer Res November 1 2017 77 (21) e58-e61; DOI:10.1158/0008-5472.CAN-17-0606

  • Focus on Computer Resources | Free Article
    PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
    Terrence F. Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A. Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A. Wiser, Patrick Dunn, Dale A. Begley, Debra M. Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H. Brush, Annette T. Byrne, Carlos Caldas, Amanda L. Christie, Dominic A. Clark, Heidi Dowst, Jonathan R. Dry, James H. Doroshow, Olivier Duchamp, Yvonne A. Evrard, Stephane Ferretti, Kristopher K. Frese, Neal C. Goodwin, Danielle Greenawalt, Melissa A. Haendel, Els Hermans, Peter J. Houghton, Jos Jonkers, Kristel Kemper, Tin O. Khor, Michael T. Lewis, K.C. Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B. Neuhauser, James M. Olson, Daniel S. Peeper, Oscar M. Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J. Wechsler-Reya, David M. Weinstock, Alana Welm, S. John Weroha, Frédéric Amant, Stefan M. Pfister, Marcel Kool, Helen Parkinson, Atul J. Butte and Carol J. Bult
    Cancer Res November 1 2017 77 (21) e62-e66; DOI:10.1158/0008-5472.CAN-17-0582

  • Focus on Computer Resources | Free Article
    The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer
    Debra M. Krupke, Dale A. Begley, John P. Sundberg, Joel E. Richardson, Steven B. Neuhauser and Carol J. Bult
    Cancer Res November 1 2017 77 (21) e67-e70; DOI:10.1158/0008-5472.CAN-17-0584

  • Focus on Computer Resources | Free Article
    Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images
    Daniel M. Spagnolo, Yousef Al-Kofahi, Peihong Zhu, Timothy R. Lezon, Albert Gough, Andrew M. Stern, Adrian V. Lee, Fiona Ginty, Brion Sarachan, D. Lansing Taylor and S. Chakra Chennubhotla
    Cancer Res November 1 2017 77 (21) e71-e74; DOI:10.1158/0008-5472.CAN-17-0676

  • Focus on Computer Resources | Free Article
    The Digital Slide Archive: A Software Platform for Management, Integration, and Analysis of Histology for Cancer Research
    David A. Gutman, Mohammed Khalilia, Sanghoon Lee, Michael Nalisnik, Zach Mullen, Jonathan Beezley, Deepak R. Chittajallu, David Manthey and Lee A.D. Cooper
    Cancer Res November 1 2017 77 (21) e75-e78; DOI:10.1158/0008-5472.CAN-17-0629

  • Focus on Computer Resources | Free Article
    A Containerized Software System for Generation, Management, and Exploration of Features from Whole Slide Tissue Images
    Joel Saltz, Ashish Sharma, Ganesh Iyer, Erich Bremer, Feiqiao Wang, Alina Jasniewski, Tammy DiPrima, Jonas S. Almeida, Yi Gao, Tianhao Zhao, Mary Saltz and Tahsin Kurc
    Cancer Res November 1 2017 77 (21) e79-e82; DOI:10.1158/0008-5472.CAN-17-0316

  • Focus on Computer Resources | Free Article
    An Image Analysis Resource for Cancer Research: PIIP—Pathology Image Informatics Platform for Visualization, Analysis, and Management
    Anne L. Martel, Dan Hosseinzadeh, Caglar Senaras, Yu Zhou, Azadeh Yazdanpanah, Rushin Shojaii, Emily S. Patterson, Anant Madabhushi and Metin N. Gurcan
    Cancer Res November 1 2017 77 (21) e83-e86; DOI:10.1158/0008-5472.CAN-17-0323

  • Focus on Computer Resources | Free Article
    dcmqi: An Open Source Library for Standardized Communication of Quantitative Image Analysis Results Using DICOM
    Christian Herz, Jean-Christophe Fillion-Robin, Michael Onken, Jörg Riesmeier, Andras Lasso, Csaba Pinter, Gabor Fichtinger, Steve Pieper, David Clunie, Ron Kikinis and Andriy Fedorov
    Cancer Res November 1 2017 77 (21) e87-e90; DOI:10.1158/0008-5472.CAN-17-0336

  • Focus on Computer Resources | Free Article
    Integrative Analysis of Histopathological Images and Genomic Data Predicts Clear Cell Renal Cell Carcinoma Prognosis
    Jun Cheng, Jie Zhang, Yatong Han, Xusheng Wang, Xiufen Ye, Yuebo Meng, Anil Parwani, Zhi Han, Qianjin Feng and Kun Huang
    Cancer Res November 1 2017 77 (21) e91-e100; DOI:10.1158/0008-5472.CAN-17-0313

  • Focus on Computer Resources | Free Article
    SlicerDMRI: Open Source Diffusion MRI Software for Brain Cancer Research
    Isaiah Norton, Walid Ibn Essayed, Fan Zhang, Sonia Pujol, Alex Yarmarkovich, Alexandra J. Golby, Gordon Kindlmann, Demian Wassermann, Raul San Jose Estepar, Yogesh Rathi, Steve Pieper, Ron Kikinis, Hans J. Johnson, Carl-Fredrik Westin and Lauren J. O'Donnell
    Cancer Res November 1 2017 77 (21) e101-e103; DOI:10.1158/0008-5472.CAN-17-0332

  • Focus on Computer Resources | Free Article
    Computational Radiomics System to Decode the Radiographic Phenotype
    Joost J.M. van Griethuysen, Andriy Fedorov, Chintan Parmar, Ahmed Hosny, Nicole Aucoin, Vivek Narayan, Regina G.H. Beets-Tan, Jean-Christophe Fillion-Robin, Steve Pieper and Hugo J.W.L. Aerts
    Cancer Res November 1 2017 77 (21) e104-e107; DOI:10.1158/0008-5472.CAN-17-0339

  • Focus on Computer Resources | Free Article
    TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells
    Taiwen Li, Jingyu Fan, Binbin Wang, Nicole Traugh, Qianming Chen, Jun S. Liu, Bo Li and X. Shirley Liu
    Cancer Res November 1 2017 77 (21) e108-e110; DOI:10.1158/0008-5472.CAN-17-0307

  • Focus on Computer Resources | Free Article
    TumorMap: Exploring the Molecular Similarities of Cancer Samples in an Interactive Portal
    Yulia Newton, Adam M. Novak, Teresa Swatloski, Duncan C. McColl, Sahil Chopra, Kiley Graim, Alana S. Weinstein, Robert Baertsch, Sofie R. Salama, Kyle Ellrott, Manu Chopra, Theodore C. Goldstein, David Haussler, Olena Morozova and Joshua M. Stuart
    Cancer Res November 1 2017 77 (21) e111-e114; DOI:10.1158/0008-5472.CAN-17-0580

  • Focus on Computer Resources | Free Article
    DeepPhe: A Natural Language Processing System for Extracting Cancer Phenotypes from Clinical Records
    Guergana K. Savova, Eugene Tseytlin, Sean Finan, Melissa Castine, Timothy Miller, Olga Medvedeva, David Harris, Harry Hochheiser, Chen Lin, Girish Chavan and Rebecca S. Jacobson
    Cancer Res November 1 2017 77 (21) e115-e118; DOI:10.1158/0008-5472.CAN-17-0615

  • Focus on Computer Resources | Free Article
    LesionTracker: Extensible Open-Source Zero-Footprint Web Viewer for Cancer Imaging Research and Clinical Trials
    Trinity Urban, Erik Ziegler, Rob Lewis, Chris Hafey, Cheryl Sadow, Annick D. Van den Abbeele and Gordon J. Harris
    Cancer Res November 1 2017 77 (21) e119-e122; DOI:10.1158/0008-5472.CAN-17-0334

  • Focus on Computer Resources | Free Article
    “Personalized Cancer Therapy”: A Publicly Available Precision Oncology Resource
    Katherine C. Kurnit, Ann M. Bailey, Jia Zeng, Amber M. Johnson, Md. Abu Shufean, Lauren Brusco, Beate C. Litzenburger, Nora S. Sánchez, Yekaterina B. Khotskaya, Vijaykumar Holla, Amy Simpson, Gordon B. Mills, John Mendelsohn, Elmer Bernstam, Kenna Shaw and Funda Meric-Bernstam
    Cancer Res November 1 2017 77 (21) e123-e126; DOI:10.1158/0008-5472.CAN-17-0341

Breaking Advances

  • Breaking Advances
    Highlights from Recent Cancer Literature
    Cancer Res November 1 2017 77 (21) 5699-5700; DOI:10.1158/0008-5472.CAN-BA-77-21

Reviews

  • Reviews
    Therapeutic Targeting of Oncogenic Tyrosine Phosphatases
    Rochelle Frankson, Zhi-Hong Yu, Yunpeng Bai, Qinglin Li, Ruo-Yu Zhang and Zhong-Yin Zhang
    Cancer Res November 1 2017 77 (21) 5701-5705; DOI:10.1158/0008-5472.CAN-17-1510

  • Reviews
    A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies
    Ophélia Maertens, Mila E. McCurrach, Benjamin S. Braun, Thomas De Raedt, Inbal Epstein, Tannie Q. Huang, Jennifer O. Lauchle, Hyerim Lee, Jianqiang Wu, Timothy P. Cripe, D. Wade Clapp, Nancy Ratner, Kevin Shannon and Karen Cichowski
    Cancer Res November 1 2017 77 (21) 5706-5711; DOI:10.1158/0008-5472.CAN-17-1789

Perspective

  • Perspective | AuthorChoice
    Meiosis-like Functions in Oncogenesis: A New View of Cancer
    Ramsay J. McFarlane and Jane A. Wakeman
    Cancer Res November 1 2017 77 (21) 5712-5716; DOI:10.1158/0008-5472.CAN-17-1535

Meeting Report

  • Meeting Report | AuthorChoice
    Moonshot Acceleration Factor: Medical Imaging
    Eva M. Sevick-Muraca, Richard A. Frank, Maryellen L. Giger and James L. Mulshine
    Cancer Res November 1 2017 77 (21) 5717-5720; DOI:10.1158/0008-5472.CAN-17-1698

Priority Report

  • Priority Report
    Discovery of Human-Similar Gene Fusions in Canine Cancers
    Ronan Ulvé, Mélanie Rault, Mathieu Bahin, Laetitia Lagoutte, Jérôme Abadie, Clotilde De Brito, Jean-Michel Coindre, Nadine Botherel, Audrey Rousseau, Valentin Wucher, Edouard Cadieu, Catherine Thieblemont, Christophe Hitte, Laurence Cornevin, Florian Cabillic, Laura Bachelot, David Gilot, Benoit Hennuy, Thierry Guillaudeux, Arnaud Le Goff, Thomas Derrien, Benoît Hédan and Catherine André
    Cancer Res November 1 2017 77 (21) 5721-5727; DOI:10.1158/0008-5472.CAN-16-2691

    These findings highlight the utility of integrating spontaneous dog models of cancer in preclinical trials to evaluate targeted therapies.

Molecular and Cellular Pathobiology

  • Molecular and Cellular Pathobiology
    miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells
    Ying Z. Mazzu, Yulan Hu, Rajesh K. Soni, Kelly M. Mojica, Li-Xuan Qin, Phaedra Agius, Zachary M. Waxman, Aleksandra Mihailovic, Nicholas D. Socci, Ronald C. Hendrickson, Thomas Tuschl and Samuel Singer
    Cancer Res November 1 2017 77 (21) 5728-5740; DOI:10.1158/0008-5472.CAN-16-2253

    These mechanistic findings reveal critical tyrosine kinase andDNA methylation pathways in liposarcoma, some with immediate implications for therapeutic exploration.

  • Molecular and Cellular Pathobiology
    Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
    Ches'Nique M. Phillips, John R. Zatarain, Michael E. Nicholls, Craig Porter, Steve G. Widen, Ketan Thanki, Paul Johnson, Muhammad U. Jawad, Mary P. Moyer, James W. Randall, Judith L. Hellmich, Manjit Maskey, Suimin Qiu, Thomas G. Wood, Nadiya Druzhyna, Bartosz Szczesny, Katalin Módis, Csaba Szabo, Celia Chao and Mark R. Hellmich
    Cancer Res November 1 2017 77 (21) 5741-5754; DOI:10.1158/0008-5472.CAN-16-3480

    These findings suggest that efforts to limit transsulfuration pathways that upregulate H2S production may have preventive benefits in limiting colorectal cancer.

  • Molecular and Cellular Pathobiology
    PADI2-Mediated Citrullination Promotes Prostate Cancer Progression
    Lin Wang, Guanhua Song, Xiang Zhang, Tingting Feng, Jihong Pan, Weiwen Chen, Muyi Yang, Xinnuo Bai, Yu Pang, Jindan Yu, Jinxiang Han and Bo Han
    Cancer Res November 1 2017 77 (21) 5755-5768; DOI:10.1158/0008-5472.CAN-17-0150

    This study reveals protein citrullination, a unique type of protein modification, as a novel pathogenic contributor to advanced prostate cancer, with immediate implications for its potential treatment given the opportunity to reposition modalities currently in clinical development for arthritis therapy.

  • Molecular and Cellular Pathobiology
    YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63–GPX2 Axis and ROS Accumulation
    Hsinyi Huang, Wenjing Zhang, Yafang Pan, Yijun Gao, Lei Deng, Fuming Li, Fei Li, Xueyan Ma, Shenda Hou, Jing Xu, Peixue Li, Xiaoxun Li, Guohong Hu, Cheng Li, Haiquan Chen, Lei Zhang and Hongbin Ji
    Cancer Res November 1 2017 77 (21) 5769-5781; DOI:10.1158/0008-5472.CAN-17-0449

    These findings indicate that the transcription factor YAP, a classic oncogene in lung adenocarcinoma, acts as a tumor suppressor in lung squamous cell carcinoma.

  • Molecular and Cellular Pathobiology
    MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway
    Tao Yu, Yingjun Zhao, Zhixiang Hu, Jing Li, Dandan Chu, Jiwei Zhang, Zhe Li, Bing Chen, Xiao Zhang, Hongyu Pan, Shengli Li, Hechun Lin, Lei Liu, Mingxia Yan, Xianghuo He and Ming Yao
    Cancer Res November 1 2017 77 (21) 5782-5794; DOI:10.1158/0008-5472.CAN-17-0671

    These results establish the long noncoding RNA MetaLnc9 as a driver of metastasis and a candidate therapeutic target for treating advanced NSCLC.

  • Molecular and Cellular Pathobiology
    Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation
    Laura E. Jackson, Sucheta Kulkarni, Huabo Wang, Jie Lu, James M. Dolezal, Sivakama S. Bharathi, Sarangarajan Ranganathan, Mulchand S. Patel, Rahul Deshpande, Frances Alencastro, Stacy G. Wendell, Eric S. Goetzman, Andrew W. Duncan and Edward V. Prochownik
    Cancer Res November 1 2017 77 (21) 5795-5807; DOI:10.1158/0008-5472.CAN-17-1325

    These striking findings show that the pyruvate dehydrogenase complex, which biochemically links glycolysis to the TCA cycle, can be completely eliminated without significantly affecting normal or neoplastic proliferation.

Tumor and Stem Cell Biology

  • Tumor and Stem Cell Biology
    Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587
    Javier Figueroa, Lynette M. Phillips, Tal Shahar, Anwar Hossain, Joy Gumin, Hoon Kim, Andrew J. Bean, George A. Calin, Juan Fueyo, Edgar T. Walters, Raghu Kalluri, Roel G. Verhaak and Frederick F. Lang
    Cancer Res November 1 2017 77 (21) 5808-5819; DOI:10.1158/0008-5472.CAN-16-2524

    These results illuminate the mechanism through which glioma-associated mesenchymal stem cells enhance the aggressiveness of glioblastoma.

  • Tumor and Stem Cell Biology
    KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling
    James V. Neiswender, Robert L. Kortum, Caitlin Bourque, Melissa Kasheta, Leonard I. Zon, Deborah K. Morrison and Craig J. Ceol
    Cancer Res November 1 2017 77 (21) 5820-5830; DOI:10.1158/0008-5472.CAN-17-0473

    These findings establish that KIT exerts a negative modifier role in melanoma by attenuating BRAFV600E activity.

  • Tumor and Stem Cell Biology
    ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling
    Qian Yan, Lingxi Jiang, Ming Liu, Dandan Yu, Yu Zhang, Yan Li, Shuo Fang, Yan Li, Ying-Hui Zhu, Yun-Fei Yuan and Xin-Yuan Guan
    Cancer Res November 1 2017 77 (21) 5831-5845; DOI:10.1158/0008-5472.CAN-17-0579

    These results suggest a secreted tumor suppressor has the potential to be developed as a novel prognostic biomarker and novel therapeutic target in liver cancer.

  • Tumor and Stem Cell Biology | AuthorChoice
    Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
    Fernando Salvador, Alberto Martin, Celia López-Menéndez, Gema Moreno-Bueno, Vanesa Santos, Alberto Vázquez-Naharro, Patricia G. Santamaria, Saleta Morales, Pierre R. Dubus, Laura Muinelo-Romay, Rafael López-López, Jason C. Tung, Valerie M. Weaver, Francisco Portillo and Amparo Cano
    Cancer Res November 1 2017 77 (21) 5846-5859; DOI:10.1158/0008-5472.CAN-16-3152

    Conditional transgenic mouse models establish a new role for an ECM regulator in metastatic invasion that is independent of its canonical function in ECM remodeling.

  • Tumor and Stem Cell Biology
    Novel SEC61G–EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens
    Tiziana Servidei, Daniela Meco, Valentina Muto, Alessandro Bruselles, Andrea Ciolfi, Nadia Trivieri, Matteo Lucchini, Roberta Morosetti, Massimiliano Mirabella, Maurizio Martini, Massimo Caldarelli, Anna Lasorella, Marco Tartaglia and Riccardo Riccardi
    Cancer Res November 1 2017 77 (21) 5860-5872; DOI:10.1158/0008-5472.CAN-17-0790

    These findings demonstrate how in vitro culture selections applied to genetically heterogenous tumors that occur rarely may help identify focal mutations that are pharmaceutically actionable in rare cancers, as in the case here for ependymoma, a rare cancer of the central nervous system.

  • Tumor and Stem Cell Biology
    ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma
    Abibatou Ndoye, Anna Budina-Kolomets, Curtis H. Kugel III, Marie R. Webster, Amanpreet Kaur, Reeti Behera, Vito W. Rebecca, Ling Li, Patricia A. Brafford, Qin Liu, Y.N. Vashisht Gopal, Michael A. Davies, Gordon B. Mills, Xiaowei Xu, Hong Wu, Meenhard Herlyn, Michael C. Nicastri, Jeffrey D. Winkler, Maria S. Soengas, Ravi K. Amaravadi, Maureen E. Murphy and Ashani T. Weeraratna
    Cancer Res November 1 2017 77 (21) 5873-5885; DOI:10.1158/0008-5472.CAN-17-0907

    Restoring β-catenin activity in Wnt5Ahigh melanoma cells sensitizes them to inhibition by the lysosomotropic agent Lys05, a finding of significance as studies to inhibit autophagy move into the clinic.

  • Tumor and Stem Cell Biology
    FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk
    Marco Chi-Chung Lau, Kai Yu Ng, Tin Lok Wong, Man Tong, Terence K. Lee, Xiao-Yan Ming, Simon Law, Nikki P. Lee, Annie L. Cheung, Yan-Ru Qin, Kwok Wah Chan, Wen Ning, Xin-Yuan Guan and Stephanie Ma
    Cancer Res November 1 2017 77 (21) 5886-5899; DOI:10.1158/0008-5472.CAN-17-1411

    These findings reveal a critical regulator of oncogenesis and metastasis in esophageal squamous cell carcinoma and highlight its potential as a biomarker and therapeutic target.

  • Tumor and Stem Cell Biology | AuthorChoice
    KDM4 Inhibition Targets Breast Cancer Stem–like Cells
    Eric Metzger, Stella S. Stepputtis, Juliane Strietz, Bogdan-Tiberius Preca, Sylvia Urban, Dominica Willmann, Anita Allen, Fides Zenk, Nicola Iovino, Peter Bronsert, Amelie Proske, Marie Follo, Melanie Boerries, Elmar Stickeler, Jiangchun Xu, Michael B. Wallace, Jeffrey A. Stafford, Toufike Kanouni, Jochen Maurer and Roland Schüle
    Cancer Res November 1 2017 77 (21) 5900-5912; DOI:10.1158/0008-5472.CAN-17-1754

    Breast cancer stem-like cells that can recapitulate triple-negative breast tumors were used in this study to help validate therapeutic targets such as the epigenetic regulator KDM4.

Therapeutics, Targets, and Chemical Biology

  • Therapeutics, Targets, and Chemical Biology | AuthorChoice
    MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy
    Mounia Beloueche-Babari, Slawomir Wantuch, Teresa Casals Galobart, Markella Koniordou, Harold G. Parkes, Vaitha Arunan, Yuen-Li Chung, Thomas R. Eykyn, Paul D. Smith and Martin O. Leach
    Cancer Res November 1 2017 77 (21) 5913-5924; DOI:10.1158/0008-5472.CAN-16-2686

    These findings show how blocking the lactate transporter MCT1 rewires metabolism to enable tumor cell survival under therapeutic challenge.

  • Therapeutics, Targets, and Chemical Biology
    Caveolae-Mediated Endocytosis Is Critical for Albumin Cellular Uptake and Response to Albumin-Bound Chemotherapy
    Moumita Chatterjee, Edgar Ben-Josef, Ryan Robb, Marall Vedaie, Star Seum, Krishnan Thirumoorthy, Kamalakannan Palanichamy, Matthew Harbrecht, Arnab Chakravarti and Terence M. Williams
    Cancer Res November 1 2017 77 (21) 5925-5937; DOI:10.1158/0008-5472.CAN-17-0604

    These findings define a key lipid raft-bound plasma membrane scaffolding protein as a predictive biomarker for the response to albumin-conjugated cancer drugs, such as the widely used antimitotic agent Abraxane.

  • Therapeutics, Targets, and Chemical Biology
    Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells
    Youssef Jounaidi, Joseph F. Cotten, Keith W. Miller and Stuart A. Forman
    Cancer Res November 1 2017 77 (21) 5938-5951; DOI:10.1158/0008-5472.CAN-17-1007

    These findings describe a strategy to improve natural killer cells as a cellular immunotherapy for cancer by engineering them to express a fusion protein that tethers interleukin-2 to its receptor IL2Rβ.

Microenvironment and Immunology

  • Microenvironment and Immunology
    Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer
    Zenobia D'Costa, Keaton Jones, Abul Azad, Ruud van Stiphout, Su Y. Lim, Ana L. Gomes, Paul Kinchesh, Sean C. Smart, W. Gillies McKenna, Francesca M. Buffa, Owen J. Sansom, Ruth J. Muschel, Eric O'Neill and Emmanouil Fokas
    Cancer Res November 1 2017 77 (21) 5952-5962; DOI:10.1158/0008-5472.CAN-16-2833

    These findings suggest TIMP1 as an appealing therapeutic target in pancreatic cancer, which continues to defy effective treatment.

  • Microenvironment and Immunology
    Enhanced Acid Sphingomyelinase Activity Drives Immune Evasion and Tumor Growth in Non–Small Cell Lung Carcinoma
    Katerina Kachler, Maximilian Bailer, Lisanne Heim, Fabian Schumacher, Martin Reichel, Corinna D. Holzinger, Sonja Trump, Susanne Mittler, Juliana Monti, Denis I. Trufa, Ralf J. Rieker, Arndt Hartmann, Horia Sirbu, Burkhard Kleuser, Johannes Kornhuber and Susetta Finotto
    Cancer Res November 1 2017 77 (21) 5963-5976; DOI:10.1158/0008-5472.CAN-16-3313

    An enzyme that controls membrane composition and dynamics in cancer cells is a potential therapeutic target for immunomodulatory therapy in lung adenocarcinoma.

  • Microenvironment and Immunology
    Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment
    Rebeca San Martin, Ravi Pathak, Antrix Jain, Sung Yun Jung, Susan G. Hilsenbeck, María C. Piña-Barba, Andrew G. Sikora, Kenneth J. Pienta and David R. Rowley
    Cancer Res November 1 2017 77 (21) 5977-5988; DOI:10.1158/0008-5472.CAN-17-0064

    This study identifies fundamental mechanisms of metastasis through the use of novel models of this process.

  • Microenvironment and Immunology
    Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand
    Sang W. Kang, Sang C. Lee, So H. Park, Juyang Kim, Hyeon H. Kim, Hyeon-Woo Lee, Su K. Seo, Byoung S. Kwon, Hong R. Cho and Byungsuk Kwon
    Cancer Res November 1 2017 77 (21) 5989-6000; DOI:10.1158/0008-5472.CAN-17-0610

    This potentially seminal study suggests a nodal role for CD137-CD137L immune signaling in the coordinate control of tumor immunosurveillance, spotlighting CD137L as an attractive intervention point to enhance cancer immunotherapy.

  • Microenvironment and Immunology
    Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques
    Hirohito Ishigaki, Toshinaga Maeda, Hirokazu Inoue, Tsuyoshi Akagi, Takako Sasamura, Hideaki Ishida, Toshiro Inubushi, Junko Okahara, Takashi Shiina, Misako Nakayama, Yasushi Itoh and Kazumasa Ogasawara
    Cancer Res November 1 2017 77 (21) 6001-6010; DOI:10.1158/0008-5472.CAN-17-0775

    These seminal findings show that adequate immune surveillance depends vitally on the generation of cancer-specific antibodies.

Integrated Systems and Technologies

  • Integrated Systems and Technologies
    Optical Coherence Tomography Detects Necrotic Regions and Volumetrically Quantifies Multicellular Tumor Spheroids
    Yongyang Huang, Shunqiang Wang, Qiongyu Guo, Sarah Kessel, Ian Rubinoff, Leo Li-Ying Chan, Peter Li, Yaling Liu, Jean Qiu and Chao Zhou
    Cancer Res November 1 2017 77 (21) 6011-6020; DOI:10.1158/0008-5472.CAN-17-0821

    These findings introduce a label-free imaging technology capable of performing live, longitudinal analysis of 3D tumor spheroids for high-throughput screening of anticancer drugs.

  • Integrated Systems and Technologies
    Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy
    Yang Zhao, Chenran Zhang, Liquan Gao, Xinhe Yu, Jianhao Lai, Dehua Lu, Rui Bao, Yanpu Wang, Bing Jia, Fan Wang and Zhaofei Liu
    Cancer Res November 1 2017 77 (21) 6021-6032; DOI:10.1158/0008-5472.CAN-17-1655

    Photodynamic therapy after chemotherapy is a promising cancer treatment strategy, with macrophage-specific molecular imaging an important potential aid in the rational design of combination therapies.

Prevention and Epidemiology

  • Prevention and Epidemiology
    Diabetes Treatments and Risks of Adverse Breast Cancer Outcomes among Early-Stage Breast Cancer Patients: A SEER-Medicare Analysis
    Lu Chen, Jessica Chubak, Denise M. Boudreau, William E. Barlow, Noel S. Weiss and Christopher I. Li
    Cancer Res November 1 2017 77 (21) 6033-6041; DOI:10.1158/0008-5472.CAN-17-0687

    A retrospect cohort of 14,766 women with stage I/II breast cancer suggests that metformin may be a preferred treatment for diabetes among women with breast cancer.

Letter to the Editor

  • Letter to the Editor
    Cross-Cancer Analysis Reveals Novel Pleiotropic Associations—Letter
    Lei Quan, Alan Hutson and Peter Demant
    Cancer Res November 1 2017 77 (21) 6042-6044; DOI:10.1158/0008-5472.CAN-16-3262

  • Letter to the Editor
    Cross-Cancer Analysis Reveals Novel Pleiotropic Associations—Response
    Rayjean J. Hung, Gordon Fehringer, Graham Casey, Stephen B. Gruber, Ulrike Peters, Ellen L. Goode, Thomas A. Sellers, Christopher A. Haiman, David J. Hunter, Peter Kraft, Christopher I. Amos, Matthew L. Freedman and Michael D. Wilson
    Cancer Res November 1 2017 77 (21) 6045-6046; DOI:10.1158/0008-5472.CAN-17-1584

Corrections

  • Corrections | Free Article
    Correction: SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming
    Cancer Res November 1 2017 77 (21) 6047-6047; DOI:10.1158/0008-5472.CAN-17-2729

  • Corrections | Free Article
    Correction: A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer
    Cancer Res November 1 2017 77 (21) 6048-6048; DOI:10.1158/0008-5472.CAN-17-2730

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Cancer Research: 77 (21)
November 2017
Volume 77, Issue 21
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Issue Highlights

  • Caveolae-Mediated Endocytosis Is Critical for Albumin Cellular Uptake and Response to Albumin-Bound Chemotherapy
  • PADI2-Mediated Citrullination Promotes Prostate Cancer Progression
  • Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation

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Cancer Research Online ISSN: 1538-7445
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