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Poster Session Abstracts

Abstract P5-11-17: Body image in women with breast cancer using a scalp cooling system to reduce chemotherapy induced alopecia

T Cigler, SA Melin, P Klein, SA Hurvitz, M Melisko, A Moore, GD Park, E Bageman, ES Ver Hoeve and HS Rugo
T Cigler
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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SA Melin
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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P Klein
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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SA Hurvitz
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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M Melisko
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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A Moore
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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GD Park
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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E Bageman
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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ES Ver Hoeve
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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HS Rugo
Weill Cornell Medical College, New York, NY; Wake Forest School of Medicine, Winston Salem, NC; Icahn School of Medicine at Mount Sinai, New York, NY; University of California Los Angeles, Lost Angeles, CA; Univeristy of California San Francisco Helen Diller Comprehensive Cancer Center, San Francisco, CA; Target Health Inc., New York, NY; Dignitana AB, Lund, Sweden
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DOI: 10.1158/1538-7445.SABCS16-P5-11-17 Published February 2017
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Abstracts: 2016 San Antonio Breast Cancer Symposium; December 6-10, 2016; San Antonio, Texas

Abstract

Background: Most women consider hair to be an important part of body image. Alopecia is an emotionally traumatic side effect for breast cancer patients undergoing adjuvant chemotherapy. The DigniCap™ Scalp Cooling System is the first scalp cooling system cleared by the US Food and Drug Administration to reduce the likelihood of chemotherapy induced alopecia.

Methods: Quality of Life (QOL) data were collected as part of a prospective clinical trial evaluating the clinical performance of scalp cooling in women with early stage BC receiving adjuvant chemotherapy.

The study's primary endpoint was hair loss as evaluated by patient self-assessment. Treatment success was defined as ≤ 50% hair loss. QOL was evaluated by the EORTC-QLQ-BR23 (BR23) administered at baseline, last chemotherapy cycle, and one month later. For BR23, 4 response categories were collapsed to 2 categories (Not at all/A little bit and Quite a bit/Very much) for analysis. QOL was compared between those with success vs. failure of scalp cooling.

Results: 101 patients were evaluable for the primary endpoint: Success was seen in 67 (66.3%) pts. QOL at study entry was comparable between pts with scalp cooling success or failure for each item in the BR23 questionnaire. Results reported as percentages of patients in each group who answered either quite a bit or very much to body image-related questions on the BR23 questionnaire are displayed in Table 1.

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BR23 results (% quite a bit/very much) one month after chemotherapy

Conclusions: Women with breast cancer using scalp cooling during chemotherapy who had hair preservation experienced improved quality of life, according to self-assessment of body image, compared to women who had significant hair loss.

Citation Format: Cigler T, Melin SA, Klein P, Hurvitz SA, Melisko M, Moore A, Park GD, Bageman E, Ver Hoeve ES, Rugo HS. Body image in women with breast cancer using a scalp cooling system to reduce chemotherapy induced alopecia [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P5-11-17.

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Cancer Research: 77 (4 Supplement)
February 2017
Volume 77, Issue 4 Supplement
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Abstract P5-11-17: Body image in women with breast cancer using a scalp cooling system to reduce chemotherapy induced alopecia
T Cigler, SA Melin, P Klein, SA Hurvitz, M Melisko, A Moore, GD Park, E Bageman, ES Ver Hoeve and HS Rugo
Cancer Res February 15 2017 (77) (4 Supplement) P5-11-17; DOI: 10.1158/1538-7445.SABCS16-P5-11-17

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Abstract P5-11-17: Body image in women with breast cancer using a scalp cooling system to reduce chemotherapy induced alopecia
T Cigler, SA Melin, P Klein, SA Hurvitz, M Melisko, A Moore, GD Park, E Bageman, ES Ver Hoeve and HS Rugo
Cancer Res February 15 2017 (77) (4 Supplement) P5-11-17; DOI: 10.1158/1538-7445.SABCS16-P5-11-17
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Cancer Research Online ISSN: 1538-7445
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