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Integrated Systems and Technologies

Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation

Linglin Yu, Mingyang Lu, Dongya Jia, Jianpeng Ma, Eshel Ben-Jacob, Herbert Levine, Benny Abraham Kaipparettu and José N. Onuchic
Linglin Yu
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
2Applied Physics Program, Rice University, Houston, Texas.
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Mingyang Lu
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
3The Jackson Laboratory, Bar Harbor, Maine.
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  • For correspondence: jonuchic@rice.edu kaippare@bcm.edu mingyang.lu@jax.org
Dongya Jia
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
4Systems, Synthetic and Physical Biology Program, Rice University, Houston, Texas.
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Jianpeng Ma
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
5Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas.
7Department of Bioengineering, Rice University, Houston, Texas.
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Eshel Ben-Jacob
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
6School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv, Israel.
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Herbert Levine
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
7Department of Bioengineering, Rice University, Houston, Texas.
8Department of Biosciences, Rice University, Houston, Texas.
9Department of Physics and Astronomy, Rice University, Houston, Texas.
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Benny Abraham Kaipparettu
10Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
11Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
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  • For correspondence: jonuchic@rice.edu kaippare@bcm.edu mingyang.lu@jax.org
José N. Onuchic
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
8Department of Biosciences, Rice University, Houston, Texas.
9Department of Physics and Astronomy, Rice University, Houston, Texas.
12Department of Chemistry, Rice University, Houston, Texas.
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  • For correspondence: jonuchic@rice.edu kaippare@bcm.edu mingyang.lu@jax.org
DOI: 10.1158/0008-5472.CAN-16-2074 Published April 2017
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Article Information

Volume 77, Issue 7, pp. 1564-1574

DOI 
https://doi.org/10.1158/0008-5472.CAN-16-2074
PubMed 
28202516

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received August 5, 2016
  • Revision received December 2, 2016
  • Accepted December 19, 2016
  • Published first February 15, 2017.

Article Versions

  • Previous version (February 15, 2017 - 10:20).
  • Previous version (March 22, 2017 - 07:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Linglin Yu1,2,
  2. Mingyang Lu1,3,*,
  3. Dongya Jia1,4,
  4. Jianpeng Ma1,5,7,
  5. Eshel Ben-Jacob1,6,†,
  6. Herbert Levine1,7,8,9,
  7. Benny Abraham Kaipparettu10,11,*, and
  8. José N. Onuchic1,8,9,12,*
  1. 1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
  2. 2Applied Physics Program, Rice University, Houston, Texas.
  3. 3The Jackson Laboratory, Bar Harbor, Maine.
  4. 4Systems, Synthetic and Physical Biology Program, Rice University, Houston, Texas.
  5. 5Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas.
  6. 6School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv, Israel.
  7. 7Department of Bioengineering, Rice University, Houston, Texas.
  8. 8Department of Biosciences, Rice University, Houston, Texas.
  9. 9Department of Physics and Astronomy, Rice University, Houston, Texas.
  10. 10Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
  11. 11Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
  12. 12Department of Chemistry, Rice University, Houston, Texas.
  1. ↵*Corresponding Authors:
    José N. Onuchic, Rice University, 6500 Main St., Houston, TX 77030. Phone: 713-348-8121; Fax: 713-348-8125; E-mail: jonuchic{at}rice.edu; Benny Abraham Kaipparettu, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Phone: 713-798-6506; E-mail: kaippare{at}bcm.edu; and Mingyang Lu, Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609. Phone: 207-288-6350; E-mail: mingyang.lu{at}jax.org
  1. L. Yu, M. Lu, and D. Jia contributed equally to this article.

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Cancer Research: 77 (7)
April 2017
Volume 77, Issue 7
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Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation
Linglin Yu, Mingyang Lu, Dongya Jia, Jianpeng Ma, Eshel Ben-Jacob, Herbert Levine, Benny Abraham Kaipparettu and José N. Onuchic
Cancer Res April 1 2017 (77) (7) 1564-1574; DOI: 10.1158/0008-5472.CAN-16-2074

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Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation
Linglin Yu, Mingyang Lu, Dongya Jia, Jianpeng Ma, Eshel Ben-Jacob, Herbert Levine, Benny Abraham Kaipparettu and José N. Onuchic
Cancer Res April 1 2017 (77) (7) 1564-1574; DOI: 10.1158/0008-5472.CAN-16-2074
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