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The molecular machinery governing cell polarity controls various aspects of cell behaviors including directional migration of cells under monolayer culture conditions. Immunofluorescence revealed that the Par-1 kinase, a critical component of the polarity-regulating machinery, is enriched on the lateral side of such migrating cells. However, in cells that were surrounded by extracellular matrix proteins, including tumor cells that have recently extravasated into the parenchyma of foreign tissues during metastasis, the Par-1 kinase was diffusely distributed throughout the cytosol. In these cells, cytosolically distributed Par-1 interfered with the critical signaling pathway driving cell proliferation, accounting for the difficulty of the recently extravasated tumor cells to initiate rapid proliferation. For details, see the article by Shibue and colleagues on page 5944.

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Cancer Research: 79 (23)
December 2019
Volume 79, Issue 23
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Issue Highlights

  • Syndecan-Mediated Ligation of ECM Proteins Triggers Proliferative Arrest of Disseminated Tumor Cells
  • Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma
  • Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host–Virus Interactions
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Copyright © 2019 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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