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Cancer Research
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Table of Contents

Breaking Insights

  • Breaking Insights
    Highlights from Recent Cancer Literature
    Cancer Res March 15 2019 79 (6) 1017-1018;

Review

  • Review
    AKT as a Therapeutic Target for Cancer
    Mengqiu Song, Ann M. Bode, Zigang Dong and Mee-Hyun Lee
    Cancer Res March 15 2019 79 (6) 1019-1031; DOI:10.1158/0008-5472.CAN-18-2738

Cancer Research Highlights

  • Cancer Research Highlights
    IFNγ, a Double-Edged Sword in Cancer Immunity and Metastasis
    Chengfei Liu and Allen C. Gao
    Cancer Res March 15 2019 79 (6) 1032-1033; DOI:10.1158/0008-5472.CAN-19-0083

  • Cancer Research Highlights
    Is Estrogen the Answer for Osteosarcoma?
    Ryan D. Roberts
    Cancer Res March 15 2019 79 (6) 1034-1035; DOI:10.1158/0008-5472.CAN-19-0209

  • Cancer Research Highlights
    Drak, Drak, Goose: A New Signaling Axis in Glioblastoma
    Justin D. Lathia
    Cancer Res March 15 2019 79 (6) 1036-1037; DOI:10.1158/0008-5472.CAN-19-0229

  • Cancer Research Highlights
    Circulating Tumor DNA Provides a Sneak Peek into Treatment Responses in Non–Small Cell Lung Cancer
    Tao Zou and Matthew Meyerson
    Cancer Res March 15 2019 79 (6) 1038-1040; DOI:10.1158/0008-5472.CAN-19-0231

  • Cancer Research Highlights
    Streamlining Detection of Fusion Genes in Colorectal Cancer: Having “Faith” in Precision Oncology in the (Tissue) “Agnostic” Era
    Nicola Valeri
    Cancer Res March 15 2019 79 (6) 1041-1043; DOI:10.1158/0008-5472.CAN-19-0305

Controversy and Consensus

  • Controversy and Consensus
    Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy
    Tareq Saleh, Liliya Tyutyunyk-Massey and David A. Gewirtz
    Cancer Res March 15 2019 79 (6) 1044-1046; DOI:10.1158/0008-5472.CAN-18-3437

Priority Report

  • Priority Report
    Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions
    Emiliano Cocco, Jamal Benhamida, Sumit Middha, Ahmet Zehir, Kerry Mullaney, Jinru Shia, Rona Yaeger, Liying Zhang, Donna Wong, Liliana Villafania, Khedoudja Nafa, Maurizio Scaltriti, Alexander Drilon, Leonard Saltz, Alison M. Schram, Zsofia K. Stadler, David M. Hyman, Ryma Benayed, Marc Ladanyi and Jaclyn F. Hechtman
    Cancer Res March 15 2019 79 (6) 1047-1053; DOI:10.1158/0008-5472.CAN-18-3126

    A high frequency of targetable kinase fusions in BRAF/RAS wild-type, microsatelltie instability-high colorectal carcinoma offers rationale for screening to identify colorectal cancer patients with kinase fusions that may respond to kinase inhibitors.

Genome and Epigenome

  • Genome and Epigenome
    Activation of Estrogen Receptor Alpha by Decitabine Inhibits Osteosarcoma Growth and Metastasis
    Maria Angeles Lillo Osuna, Jesus Garcia-Lopez, Ikbale El Ayachi, Iram Fatima, Aysha B. Khalid, Jerusha Kumpati, Alexandria V. Slayden, Tiffany N. Seagroves, Gustavo A. Miranda-Carboni and Susan A. Krum
    Cancer Res March 15 2019 79 (6) 1054-1068; DOI:10.1158/0008-5472.CAN-18-1255

    These findings describe the effects of DNA methyltransferase inhibition on ERa and its potential role as a tumor suppressor in osteosarcoma.

Metabolism and Chemical Biology

  • Metabolism and Chemical Biology | AuthorChoice
    Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription
    Song Fan, Tian Tian, Weixiong Chen, Xiaobin Lv, Xinyuan Lei, Hanqing Zhang, Sheng Sun, Lei Cai, Guokai Pan, Lile He, Zhanpeng Ou, Xinyu Lin, Xinhui Wang, Matthew Francis Perez, Zhiming Tu, Soldano Ferrone, Bakhos A. Tannous and Jinsong Li
    Cancer Res March 15 2019 79 (6) 1069-1084; DOI:10.1158/0008-5472.CAN-18-2505

    These findings uncover a novel mechanism by which mitomiRNA regulates mitochondrial transcription and provide rationale for use of mitomiRNA and mtDNAencoded genes to predict chemosensitivity and patient clinical prognosis.

Molecular Cell Biology

  • Molecular Cell Biology
    Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling
    Alexander S. Chen, Joanna Wardwell-Ozgo, Nilang N. Shah, Deidre Wright, Christina L. Appin, Krishanthan Vigneswaran, Daniel J. Brat, Harley I. Kornblum and Renee D. Read
    Cancer Res March 15 2019 79 (6) 1085-1097; DOI:10.1158/0008-5472.CAN-18-0482

    These findings reveal new insights into differential regulation of cell proliferation in malignant brain tumors, which will have a broader impact on research regarding mechanisms of oncogene cooperation and dependencies in cancer.

  • Molecular Cell Biology
    IFNγ-Induced IFIT5 Promotes Epithelial-to-Mesenchymal Transition in Prostate Cancer via miRNA Processing
    U-Ging Lo, Rey-Chen Pong, Diane Yang, Leah Gandee, Elizabeth Hernandez, Andrew Dang, Chung-Jung Lin, John Santoyo, Shihong Ma, Rajni Sonavane, Jun Huang, Shu-Fen Tseng, Loredana Moro, Arnaldo A. Arbini, Payal Kapur, Ganesh V. Raj, Dalin He, Chih-Ho Lai, Ho Lin and Jer-Tsong Hsieh
    Cancer Res March 15 2019 79 (6) 1098-1112; DOI:10.1158/0008-5472.CAN-18-2207

    A unique IFIT5-XRN1 complex involved in the turnover of specific tumor suppressive microRNAs is the underlying mechanism of IFNγ-induced epithelial-tomesenchymal transition in prostate cancer.

Tumor Biology and Immunology

  • Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
    Tumor Biology and Immunology | AuthorChoice
    Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma
    Bradley D. Shields, Brian Koss, Erin M. Taylor, Aaron J. Storey, Kirk L. West, Stephanie D. Byrum, Samuel G. Mackintosh, Rick Edmondson, Fade Mahmoud, Sara C. Shalin and Alan J. Tackett
    Cancer Res March 15 2019 79 (6) 1113-1123; DOI:10.1158/0008-5472.CAN-18-1722

    These findings identify the mechanism behind checkpoint blockade resistance observed in melanoma that has undergone mesenchymal transition and suggest activation of CD103+ immune cells as a therapeutic strategy against other E-cadherin-expressing malignancies.

  • Constant Degradation of the Androgen Receptor by MDM2 Conserves Prostate Cancer Stem Cell Integrity
    Tumor Biology and Immunology
    Constant Degradation of the Androgen Receptor by MDM2 Conserves Prostate Cancer Stem Cell Integrity
    Premkumar Vummidi Giridhar, Karin Williams, Andrew P. VonHandorf, Paul L. Deford and Susan Kasper
    Cancer Res March 15 2019 79 (6) 1124-1137; DOI:10.1158/0008-5472.CAN-18-1753

    These findings provide a novel mechanistic aspect of prostate cancer cell stemness that advances our understanding of the diverse transcriptional activity that bypasses AR in contributing to therapeutic resistance, tumor progression, and metastasis.

  • Tumor Biology and Immunology
    IDO1 and Kynurenine Pathway Metabolites Activate PI3K-Akt Signaling in the Neoplastic Colon Epithelium to Promote Cancer Cell Proliferation and Inhibit Apoptosis
    Kumar S. Bishnupuri, David M. Alvarado, Alexander N. Khouri, Mark Shabsovich, Baosheng Chen, Brian K. Dieckgraefe and Matthew A. Ciorba
    Cancer Res March 15 2019 79 (6) 1138-1150; DOI:10.1158/0008-5472.CAN-18-0668

    This study defines a new mechanistic link between IDO1 activity and PI3K/AKT signaling, both of which are important pathways involved in cancer growth and resistance to cancer therapy.

  • Tumor Biology and Immunology
    Natural Killer–Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms
    Paolo Neviani, Petra M. Wise, Mariam Murtadha, Cathy W. Liu, Chun-Hua Wu, Ambrose Y. Jong, Robert C. Seeger and Muller Fabbri
    Cancer Res March 15 2019 79 (6) 1151-1164; DOI:10.1158/0008-5472.CAN-18-0779

    These findings highlight the therapeutic potential of NK cell-derived exosomes containing the tumor suppressor miR-186 that inhibits growth, spreading, and TGFβ-dependent immune escape mechanisms in neuroblastoma.

  • Tumor Biology and Immunology
    An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia–Microenvironment Interactions and Confers Drug Resistance in AML
    Bing Z. Carter, Po Yee Mak, Xiangmeng Wang, Wenjing Tao, Vivian Ruvolo, Duncan Mak, Hong Mu, Jared K. Burks and Michael Andreeff
    Cancer Res March 15 2019 79 (6) 1165-1177; DOI:10.1158/0008-5472.CAN-18-0921

    The antiapoptotic protein ARC promotes AML aggressiveness by enabling detrimental cross-talk with bone marrow mesenchymal stromal cells.

  • Tumor Biology and Immunology
    GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon
    Mohammad Salem, Caroline Wallace, Maria Velegraki, Anqi Li, Ephraim Ansa-Addo, Alessandra Metelli, Hyunwoo Kwon, Brian Riesenberg, Bill Wu, Yongliang Zhang, Silvia Guglietta, Shaoli Sun, Bei Liu and Zihai Li
    Cancer Res March 15 2019 79 (6) 1178-1190; DOI:10.1158/0008-5472.CAN-18-2623

    These findings uncover functions of membrane-bound TGFβ and GARP that tune the activity of Treg cells, highlighting a potential treatment strategy in autoimmune diseases and cancer.

  • Tumor Biology and Immunology
    BET Inhibitors Potentiate Chemotherapy and Killing of SPOP-Mutant Colon Cancer Cells via Induction of DR5
    Xiao Tan, Jingshan Tong, Yi-Jun Wang, Rochelle Fletcher, Robert E. Schoen, Jian Yu, Liangfang Shen and Lin Zhang
    Cancer Res March 15 2019 79 (6) 1191-1203; DOI:10.1158/0008-5472.CAN-18-3223

    These findings reveal how BET inhibition sensitizes chemotherapy and kills a subset of colon cancer cells with specific genetic alterations and may provide a new molecular marker for improving colon cancer therapies.

Translational Science

  • Translational Science | AuthorChoice
    Early Noninvasive Detection of Response to Targeted Therapy in Non–Small Cell Lung Cancer
    Jillian Phallen, Alessandro Leal, Brian D. Woodward, Patrick M. Forde, Jarushka Naidoo, Kristen A. Marrone, Julie R. Brahmer, Jacob Fiksel, Jamie E. Medina, Stephen Cristiano, Doreen N. Palsgrove, Christopher D. Gocke, Daniel C. Bruhm, Parissa Keshavarzian, Vilmos Adleff, Elizabeth Weihe, Valsamo Anagnostou, Robert B. Scharpf, Victor E. Velculescu and Hatim Husain
    Cancer Res March 15 2019 79 (6) 1204-1213; DOI:10.1158/0008-5472.CAN-18-1082

    Cell-free tumor load provides a novel approach for evaluating longitudinal changes in ctDNA during systemic treatment with tyrosine kinase inhibitors and serves an unmet clinical need for real-time, noninvasive detection of tumor response to targeted therapies before radiographic assessment.

  • Translational Science | AuthorChoice
    Dynamics of Tumor and Immune Responses during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer
    Valsamo Anagnostou, Patrick M. Forde, James R. White, Noushin Niknafs, Carolyn Hruban, Jarushka Naidoo, Kristen Marrone, I.K. Ashok Sivakumar, Daniel C. Bruhm, Samuel Rosner, Jillian Phallen, Alessandro Leal, Vilmos Adleff, Kellie N. Smith, Tricia R. Cottrell, Lamia Rhymee, Doreen N. Palsgrove, Christine L. Hann, Benjamin Levy, Josephine Feliciano, Christos Georgiades, Franco Verde, Peter Illei, Qing Kay Li, Edward Gabrielson, Malcolm V. Brock, James M. Isbell, Jennifer L. Sauter, Janis Taube, Robert B. Scharpf, Rachel Karchin, Drew M. Pardoll, Jamie E. Chaft, Matthew D. Hellmann, Julie R. Brahmer and Victor E. Velculescu
    Cancer Res March 15 2019 79 (6) 1214-1225; DOI:10.1158/0008-5472.CAN-18-1127

    Rapid and sensitive detection of circulating tumor DNA dynamic changes and T-cell expansion can be used to guide immune targeted therapy for patients with lung cancer.

  • Translational Science | AuthorChoice
    A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications
    Matthieu Gobin, Petr V. Nazarov, Rolf Warta, Marco Timmer, Guido Reifenberger, Joerg Felsberg, Laurent Vallar, Anthony J. Chalmers, Christel C. Herold-Mende, Roland Goldbrunner, Simone P. Niclou and Eric Van Dyck
    Cancer Res March 15 2019 79 (6) 1226-1238; DOI:10.1158/0008-5472.CAN-18-2076

    These findings suggest that classification of GBM tumors based on a DNA repair and cell-cycle gene expression signature exposes vulnerabilities to standard-ofcare therapies and offers the potential for personalized therapeutic strategies.

  • Translational Science | AuthorChoice
    Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk
    Tao Sun, Rameshwar Patil, Anna Galstyan, Dmytro Klymyshyn, Hui Ding, Alexandra Chesnokova, Webster K. Cavenee, Frank B. Furnari, Vladimir A. Ljubimov, Ekaterina S. Shatalova, Shawn Wagner, Debiao Li, Adam N. Mamelak, Serguei I. Bannykh, Chirag G. Patil, Jeremy D. Rudnick, Jethro Hu, Zachary B. Grodzinski, Arthur Rekechenetskiy, Vida Falahatian, Alexander V. Lyubimov, Yongmei L. Chen, Lai S. Leoh, Tracy R. Daniels-Wells, Manuel L. Penichet, Eggehard Holler, Alexander V. Ljubimov, Keith L. Black and Julia Y. Ljubimova
    Cancer Res March 15 2019 79 (6) 1239-1251; DOI:10.1158/0008-5472.CAN-18-2725

    Laminin-411 expression in the glioma microenvironment correlates with Notch and other cancer stem cell markers and can be targeted by a novel, clinically translatable nanobioconjugate to inhibit glioma growth.

Population and Prevention Science

  • Population and Prevention Science | AuthorChoice
    Epidemiologic and Clinical Analysis of Cervical Cancer Using Data from the Population-Based Osaka Cancer Registry
    Asami Yagi, Yutaka Ueda, Mamoru Kakuda, Yusuke Tanaka, Sayaka Ikeda, Shinya Matsuzaki, Eiji Kobayashi, Toshitaka Morishima, Isao Miyashiro, Keisuke Fukui, Yuri Ito, Tomio Nakayama and Tadashi Kimura
    Cancer Res March 15 2019 79 (6) 1252-1259; DOI:10.1158/0008-5472.CAN-18-3109

    A large cohort analysis of cervical cancer cases reveals that age-adjusted incidence in Japan has increased since 2000 and that age may negatively correlate with resistance to radiation therapy.

Correction

  • Correction | Free Article
    Correction: Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma
    Weikun Xiao, Rongyu Zhang, Alireza Sohrabi, Arshia Ehsanipour, Songping Sun, Jesse Liang, Christopher M. Walthers, Lisa Ta, David A. Nathanson and Stephanie K. Seidlits
    Cancer Res March 15 2019 79 (6) 1260-1260; DOI:10.1158/0008-5472.CAN-19-0265

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Cancer Research: 79 (6)
March 2019
Volume 79, Issue 6
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Issue Highlights

  • Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription
  • Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling
  • Early Noninvasive Detection of Response to Targeted Therapy in Non–Small Cell Lung Cancer

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Cancer Research Online ISSN: 1538-7445
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