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Cancer Research Highlights

Several Faces of Glutaminase Regulation in Cells

Ana C.P. Mafra and Sandra M.G. Dias
Ana C.P. Mafra
Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Sao Paulo, Brazil. Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas – UNICAMP, Campinas, Sao Paulo, Brazil.
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Sandra M.G. Dias
Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Sao Paulo, Brazil.
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  • For correspondence: Sandra.dias@lnbio.cnpem.br
DOI: 10.1158/0008-5472.CAN-19-0313 Published April 2019
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Abstract

The cancer target glutaminase (GLS) has proven to be a fascinating protein. Since it was first described to be regulated by the oncogene Myc 10 years ago, several other transcriptional, posttranscriptional, and posttranslational regulatory mechanisms have emerged, and the list is growing. A recent study by Deng and colleagues revealed that an antisense (AS) long noncoding RNA named GLS-AS, which is negatively regulated by Myc, downregulates GLS in pancreatic cancer. The Myc/GLS-AS/GLS regulatory axis is activated by nutrient stress, which is important for the often hypovascular pancreatic cancer, displaying the significance of GLS for the progression of this highly lethal type of cancer.

See related article by Deng et al., p. 1398

  • Received January 24, 2019.
  • Accepted January 25, 2019.
  • Published first April 1, 2019.
  • ©2019 American Association for Cancer Research.
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Cancer Research: 79 (7)
April 2019
Volume 79, Issue 7
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Several Faces of Glutaminase Regulation in Cells
Ana C.P. Mafra and Sandra M.G. Dias
Cancer Res April 1 2019 (79) (7) 1302-1304; DOI: 10.1158/0008-5472.CAN-19-0313

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Several Faces of Glutaminase Regulation in Cells
Ana C.P. Mafra and Sandra M.G. Dias
Cancer Res April 1 2019 (79) (7) 1302-1304; DOI: 10.1158/0008-5472.CAN-19-0313
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Cancer Research Online ISSN: 1538-7445
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