Abstract 6670: Combined signals from tumor and immune cells predict outcomes of checkpoint inhibition in melanoma

Samuel S. Freeman; Moshe Sade-Feldman; Jaegil Kim; Chip Stewart; Arvind Ravi; Monica Arniella; Keren Yizhak; Ignaty Leshchiner; Liudmila Elagina; Oliver Spiro; Dimitri Livitz; Daniel Rosebrock; François Aguet; Jian Carrot-Zhang; Anna Gonye; Gavin Ha; Ziao Lin; Jonathan H. Chen; Dennie T. Frederick; Michal Barzily-Rokni; Marc R. Hammond; Hans Vitzthum; Shauna M. Blackmon; Yunxin J. Jiao; Donald P. Lawrence; Lyn M. Duncan; Anat Stemmer-Rachamimov; Jennifer A. Wargo; Keith T. Flaherty; Genevieve M. Boland; Ryan J. Sullivan; Matthew Meyerson; Gad Getz; Nir Hacohen

doi:10.1158/1538-7445.AM2020-6670

Immunology

Abstract 6670: Combined signals from tumor and immune cells predict outcomes of checkpoint inhibition in melanoma

Samuel S. Freeman, Moshe Sade-Feldman, Jaegil Kim, Chip Stewart, Arvind Ravi, Monica Arniella, Keren Yizhak, Ignaty Leshchiner, Liudmila Elagina, Oliver Spiro, Dimitri Livitz, Daniel Rosebrock, François Aguet, Jian Carrot-Zhang, Anna Gonye, Gavin Ha, Ziao Lin, Jonathan H. Chen, Dennie T. Frederick, Michal Barzily-Rokni, Marc R. Hammond, Hans Vitzthum, Shauna M. Blackmon, Yunxin J. Jiao, Donald P. Lawrence, Lyn M. Duncan, Anat Stemmer-Rachamimov, Jennifer A. Wargo, Keith T. Flaherty, Genevieve M. Boland, Ryan J. Sullivan, Matthew Meyerson, Gad Getz and Nir Hacohen

Samuel S. Freeman

1Broad Institute, Cambridge, MA;

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Moshe Sade-Feldman

2Massachusetts General Hospital, Boston, MA;

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Jaegil Kim

1Broad Institute, Cambridge, MA;

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Chip Stewart

1Broad Institute, Cambridge, MA;

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Arvind Ravi

1Broad Institute, Cambridge, MA;

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Monica Arniella

1Broad Institute, Cambridge, MA;

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Keren Yizhak

1Broad Institute, Cambridge, MA;

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Ignaty Leshchiner

1Broad Institute, Cambridge, MA;

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Liudmila Elagina

1Broad Institute, Cambridge, MA;

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Oliver Spiro

1Broad Institute, Cambridge, MA;

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Dimitri Livitz

1Broad Institute, Cambridge, MA;

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Daniel Rosebrock

1Broad Institute, Cambridge, MA;

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François Aguet

1Broad Institute, Cambridge, MA;

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Jian Carrot-Zhang

1Broad Institute, Cambridge, MA;

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Anna Gonye

2Massachusetts General Hospital, Boston, MA;

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Gavin Ha

3Fred Hutchinson Cancer Research Center, Seattle, WA;

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Ziao Lin

1Broad Institute, Cambridge, MA;

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Jonathan H. Chen

2Massachusetts General Hospital, Boston, MA;

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Dennie T. Frederick

2Massachusetts General Hospital, Boston, MA;

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Michal Barzily-Rokni

2Massachusetts General Hospital, Boston, MA;

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Marc R. Hammond

2Massachusetts General Hospital, Boston, MA;

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Hans Vitzthum

2Massachusetts General Hospital, Boston, MA;

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Shauna M. Blackmon

2Massachusetts General Hospital, Boston, MA;

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Yunxin J. Jiao

1Broad Institute, Cambridge, MA;

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Donald P. Lawrence

2Massachusetts General Hospital, Boston, MA;

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Lyn M. Duncan

2Massachusetts General Hospital, Boston, MA;

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Anat Stemmer-Rachamimov

2Massachusetts General Hospital, Boston, MA;

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Jennifer A. Wargo

4University of Texas MD Anderson Cancer Center, Houston, TX;

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Keith T. Flaherty

2Massachusetts General Hospital, Boston, MA;

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Genevieve M. Boland

2Massachusetts General Hospital, Boston, MA;

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Ryan J. Sullivan

2Massachusetts General Hospital, Boston, MA;

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Matthew Meyerson

5Dana-Farber Cancer Institute, Boston, MA.

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Gad Getz

2Massachusetts General Hospital, Boston, MA;

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Nir Hacohen

2Massachusetts General Hospital, Boston, MA;

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DOI: 10.1158/1538-7445.AM2020-6670 Published August 2020

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Volume 80, Issue 16 Supplement, pp. 6670

DOI

https://doi.org/10.1158/1538-7445.AM2020-6670

Published By

American Association for Cancer Research

Print ISSN

0008-5472

Online ISSN

1538-7445

Author Information

Samuel S. Freeman1,
Moshe Sade-Feldman2,
Jaegil Kim1,
Chip Stewart1,
Arvind Ravi1,
Monica Arniella1,
Keren Yizhak1,
Ignaty Leshchiner1,
Liudmila Elagina1,
Oliver Spiro1,
Dimitri Livitz1,
Daniel Rosebrock1,
François Aguet1,
Jian Carrot-Zhang1,
Anna Gonye2,
Gavin Ha3,
Ziao Lin1,
Jonathan H. Chen2,
Dennie T. Frederick2,
Michal Barzily-Rokni2,
Marc R. Hammond2,
Hans Vitzthum2,
Shauna M. Blackmon2,
Yunxin J. Jiao1,
Donald P. Lawrence2,
Lyn M. Duncan2,
Anat Stemmer-Rachamimov2,
Jennifer A. Wargo4,
Keith T. Flaherty2,
Genevieve M. Boland2,
Ryan J. Sullivan2,
Matthew Meyerson5,
Gad Getz2, and
Nir Hacohen2

¹Broad Institute, Cambridge, MA;
²Massachusetts General Hospital, Boston, MA;
³Fred Hutchinson Cancer Research Center, Seattle, WA;
⁴University of Texas MD Anderson Cancer Center, Houston, TX;
⁵Dana-Farber Cancer Institute, Boston, MA.

August 2020
Volume 80, Issue 16 Supplement

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Abstract 6670: Combined signals from tumor and immune cells predict outcomes of checkpoint inhibition in melanoma

Cancer Res August 15 2020 (80) (16 Supplement) 6670; DOI: 10.1158/1538-7445.AM2020-6670

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Abstract 6670: Combined signals from tumor and immune cells predict outcomes of checkpoint inhibition in melanoma

Cancer Res August 15 2020 (80) (16 Supplement) 6670; DOI: 10.1158/1538-7445.AM2020-6670

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