A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer

Meera Saxena; Ravi K.R. Kalathur; Natalia Rubinstein; Andrea Vettiger; Nami Sugiyama; Melanie Neutzner; Mairene Coto-Llerena; Venkatesh Kancherla; Caner Ercan; Salvatore Piscuoglio; Jonas Fischer; Ernesta Fagiani; Claudio Cantù; Konrad Basler; Gerhard Christofori

doi:10.1158/0008-5472.CAN-19-2910

Tumor Biology and Immunology

A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer

Meera Saxena, Ravi K.R. Kalathur, Natalia Rubinstein, Andrea Vettiger, Nami Sugiyama, Melanie Neutzner, Mairene Coto-Llerena, Venkatesh Kancherla, Caner Ercan, Salvatore Piscuoglio, Jonas Fischer, Ernesta Fagiani, Claudio Cantù, Konrad Basler and Gerhard Christofori

Meera Saxena

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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For correspondence: gerhard.christofori@unibas.ch meera.saxena@unibas.ch

Ravi K.R. Kalathur

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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Natalia Rubinstein

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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Andrea Vettiger

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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Nami Sugiyama

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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Melanie Neutzner

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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Mairene Coto-Llerena

2Institute of Pathology, University Hospital Basel, Basel, Switzerland.

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Venkatesh Kancherla

2Institute of Pathology, University Hospital Basel, Basel, Switzerland.

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Caner Ercan

2Institute of Pathology, University Hospital Basel, Basel, Switzerland.

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Salvatore Piscuoglio

2Institute of Pathology, University Hospital Basel, Basel, Switzerland.

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Jonas Fischer

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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Ernesta Fagiani

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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Claudio Cantù

3Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

4Wallenberg Centre for Molecular Medicine Linköping; Department of Biomedical and Clinical Sciences, Faculty of Health Science, Linköping University, Linköping, Sweden.

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Konrad Basler

3Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

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Gerhard Christofori

1Department of Biomedicine, University of Basel, Basel, Switzerland.

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For correspondence: gerhard.christofori@unibas.ch meera.saxena@unibas.ch

DOI: 10.1158/0008-5472.CAN-19-2910 Published September 2020

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September 2020
Volume 80, Issue 17

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A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer