YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis

Stefan Thomann; Sofia M.E. Weiler; Simone Marquard; Fabian Rose; Claudia R. Ball; Marcell Tóth; Teng Wei; Carsten Sticht; Sarah Fritzsche; Stephanie Roessler; Carolina De La Torre; Eduard Ryschich; Olga Ermakova; Carolin Mogler; Daniel Kazdal; Norbert Gretz; Hanno Glimm; Eugen Rempel; Peter Schirmacher; Kai Breuhahn

doi:10.1158/0008-5472.CAN-20-0242

Molecular Cell Biology

YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis

Stefan Thomann, Sofia M.E. Weiler, Simone Marquard, Fabian Rose, Claudia R. Ball, Marcell Tóth, Teng Wei, Carsten Sticht, Sarah Fritzsche, Stephanie Roessler, Carolina De La Torre, Eduard Ryschich, Olga Ermakova, Carolin Mogler, Daniel Kazdal, Norbert Gretz, Hanno Glimm, Eugen Rempel, Peter Schirmacher and Kai Breuhahn

Stefan Thomann

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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For correspondence: kai.breuhahn@med.uni-heidelberg.de thomann@ie-freiburg.mpg.de

Sofia M.E. Weiler

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Simone Marquard

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Fabian Rose

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Claudia R. Ball

2Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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ORCID record for Claudia R. Ball

Marcell Tóth

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Teng Wei

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Carsten Sticht

3Medical Research Center, University of Heidelberg, Heidelberg, Germany.

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Sarah Fritzsche

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Stephanie Roessler

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Carolina De La Torre

3Medical Research Center, University of Heidelberg, Heidelberg, Germany.

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Eduard Ryschich

4Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany.

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Olga Ermakova

5Center for Organismal Studies, University Heidelberg, Heidelberg, Germany.

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Carolin Mogler

6Institute of Pathology, Technical University of Munich, Munich, Germany.

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Daniel Kazdal

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Norbert Gretz

3Medical Research Center, University of Heidelberg, Heidelberg, Germany.

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Hanno Glimm

2Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.

7Translational Functional Cancer Genomics, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.

8Center for Personalized Oncology, University Hospital Carl Gustav Carus TU Dresden, Germany.

9German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.

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Eugen Rempel

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Peter Schirmacher

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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Kai Breuhahn

1Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

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For correspondence: kai.breuhahn@med.uni-heidelberg.de thomann@ie-freiburg.mpg.de

DOI: 10.1158/0008-5472.CAN-20-0242 Published December 2020

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December 2020
Volume 80, Issue 24

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YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis