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Poster Session Abstracts

Abstract P4-01-17: Viable circulating ensembles of tumor associated cells persist in patients with no radiologically detectable disease after treatment in breast cancer

Ajay Srinivasan, Dadasaheb Akolkar, Darshana Patil, Timothy Crook, Cynthe Sims, Revati Patil, Vineet Datta, Anantbhushan Ranade, Pradip Fulmali, Pradip Devhare, Pooja Fulmali, Shoeb Patel, Akshay Ainwale, Sneha Puranik and Rajan Datar
Ajay Srinivasan
1Datar Cancer Genetics Limited, Nasik, India
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Dadasaheb Akolkar
1Datar Cancer Genetics Limited, Nasik, India
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Darshana Patil
1Datar Cancer Genetics Limited, Nasik, India
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Timothy Crook
2Royal Surrey County Hospital, Guildford, United Kingdom
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Cynthe Sims
1Datar Cancer Genetics Limited, Nasik, India
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Revati Patil
1Datar Cancer Genetics Limited, Nasik, India
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Vineet Datta
1Datar Cancer Genetics Limited, Nasik, India
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Anantbhushan Ranade
3Avinash Cancer Clinic, Pune, India
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Pradip Fulmali
1Datar Cancer Genetics Limited, Nasik, India
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Pradip Devhare
1Datar Cancer Genetics Limited, Nasik, India
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Pooja Fulmali
1Datar Cancer Genetics Limited, Nasik, India
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Shoeb Patel
1Datar Cancer Genetics Limited, Nasik, India
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Akshay Ainwale
1Datar Cancer Genetics Limited, Nasik, India
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Sneha Puranik
1Datar Cancer Genetics Limited, Nasik, India
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Rajan Datar
1Datar Cancer Genetics Limited, Nasik, India
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DOI: 10.1158/1538-7445.SABCS19-P4-01-17 Published February 2020
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Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas

Abstract

Oncological orthodoxy holds that (metastatic) breast cancer is an incurable disease. Response evaluation in metastatic breast cancer is determined by clinical, biochemical and radiological parameters, FDG PET CT being the imaging modality of choice for most types of breast cancer. However, even in cases where FDG PET CT and/or normalisation of serum tumour markers imply complete response to systemic therapy, durable disease-free survival is uncommon. To explore the mechanistic basis underlying persistent disease in spite of apparently effective systemic therapy, we hypothesized that Circulating Metastatic Disease (CMD) in the form of viable tumor cells or clusters might be a feature of persisting breast cancer. To address this, we obtained 15ml of peripheral blood from 927 known and previously treated cases of breast cancers immediately prior to FDG PET CT restaging. Peripheral blood mononuclear cells (PBMCs) were harvested by centrifugation. Circulating Ensembles of Tumor Associated Cells (C-ETACs), which are clusters of heterotypic apoptosis resistant cells of tumorigenic origin were enriched by a novel process using a combination of commercially available stabilizing agents. C-ETACs were characterized by immunostaining for EpCAM, pan-CK and CD45 as well as GCDFP-15 or GATA3. 927 patients underwent FDG PET CT of whom 731 (78.9%) had evidence of FDG avid residual disease. 196 patients (21.1%) had no metabolically active disease, among whom C-ETACs were detected in 171/196 cases (87.2%). The presence of CMD in a high proportion of cases in patients with no evidence of metabolically active disease implies that the majority of patients in whom conventional parameters of disease are negative have residual disease and are not biologically cured.

Citation Format: Ajay Srinivasan, Dadasaheb Akolkar, Darshana Patil, Timothy Crook, Cynthe Sims, Revati Patil, Vineet Datta, Anantbhushan Ranade, Pradip Fulmali, Pradip Devhare, Pooja Fulmali, Shoeb Patel, Akshay Ainwale, Sneha Puranik, Rajan Datar. Viable circulating ensembles of tumor associated cells persist in patients with no radiologically detectable disease after treatment in breast cancer [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P4-01-17.

  • ©2020 American Association for Cancer Research.
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Cancer Research: 80 (4 Supplement)
February 2020
Volume 80, Issue 4 Supplement
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Abstract P4-01-17: Viable circulating ensembles of tumor associated cells persist in patients with no radiologically detectable disease after treatment in breast cancer
Ajay Srinivasan, Dadasaheb Akolkar, Darshana Patil, Timothy Crook, Cynthe Sims, Revati Patil, Vineet Datta, Anantbhushan Ranade, Pradip Fulmali, Pradip Devhare, Pooja Fulmali, Shoeb Patel, Akshay Ainwale, Sneha Puranik and Rajan Datar
Cancer Res February 15 2020 (80) (4 Supplement) P4-01-17; DOI: 10.1158/1538-7445.SABCS19-P4-01-17

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Abstract P4-01-17: Viable circulating ensembles of tumor associated cells persist in patients with no radiologically detectable disease after treatment in breast cancer
Ajay Srinivasan, Dadasaheb Akolkar, Darshana Patil, Timothy Crook, Cynthe Sims, Revati Patil, Vineet Datta, Anantbhushan Ranade, Pradip Fulmali, Pradip Devhare, Pooja Fulmali, Shoeb Patel, Akshay Ainwale, Sneha Puranik and Rajan Datar
Cancer Res February 15 2020 (80) (4 Supplement) P4-01-17; DOI: 10.1158/1538-7445.SABCS19-P4-01-17
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