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Research Article

Role of Chitinase 3-like-1 and Semaphorin 7A in Pulmonary Melanoma Metastasis

Bing Ma, Erica L Herzog, Chun Geun Lee, Xueyan Peng, Chang-Min Lee, Xiaosong Chen, Sara Rockwell, Ja Seok Koo, Harriet Kluger, Roy S. Herbst, Mario Sznol and Jack Elias
Bing Ma
1Department of Molecular Microbiology and Immunology, Brown University
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Erica L Herzog
2Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine
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Chun Geun Lee
3Molecular Microbiology and Immunology, Brown University
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Xueyan Peng
2Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine
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Chang-Min Lee
1Department of Molecular Microbiology and Immunology, Brown University
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Xiaosong Chen
2Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine
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Sara Rockwell
4Therapeutic Radiology, Yale Cancer Center
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Ja Seok Koo
5Section of Medical Oncology, Yale University School of Medicine
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Harriet Kluger
6Section of Medical Oncology, Yale Cancer Center, Yale University School of Medicine
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Roy S. Herbst
5Section of Medical Oncology, Yale University School of Medicine
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Mario Sznol
5Section of Medical Oncology, Yale University School of Medicine
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Jack Elias
1Department of Molecular Microbiology and Immunology, Brown University
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  • For correspondence: jack_elias@brown.edu
DOI: 10.1158/0008-5472.CAN-13-3339
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    • Supplementary Figures 1-5 - Supplementary Figures 1-5. Supplementary Figure 1. Dose and time kinetic evaluation of the production of Chi3l1 by recombinant murine Sema7a (rmSema7a) stimulated macrophages. Supplementary Figure 2. Double label immunohistochemical staining of CD4, Ly-6G, and Chi3l1. Supplementary Figure 3. Growth of melanoma cells 10 weeks of B16-F10 cell subcutaneous (s.c.) inoculation. Supplementary Figure 4. The expression of Chi3l1 and Sema7a in lungs with and without metastatic breast cancer cells. Supplementary Figure 5. Role of integrin β3 in Sema7a-stimualted expression of Chi3l1.
    • Supplementary Figure Legend - Supplementary Figure Legend
    • Supplementary Materials and Methods - Supplementary Materials and Methods
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This OnlineFirst version was published on December 15, 2014
doi: 10.1158/0008-5472.CAN-13-3339

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Role of Chitinase 3-like-1 and Semaphorin 7A in Pulmonary Melanoma Metastasis
Bing Ma, Erica L Herzog, Chun Geun Lee, Xueyan Peng, Chang-Min Lee, Xiaosong Chen, Sara Rockwell, Ja Seok Koo, Harriet Kluger, Roy S. Herbst, Mario Sznol and Jack Elias
Cancer Res December 15 2014 DOI: 10.1158/0008-5472.CAN-13-3339

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Role of Chitinase 3-like-1 and Semaphorin 7A in Pulmonary Melanoma Metastasis
Bing Ma, Erica L Herzog, Chun Geun Lee, Xueyan Peng, Chang-Min Lee, Xiaosong Chen, Sara Rockwell, Ja Seok Koo, Harriet Kluger, Roy S. Herbst, Mario Sznol and Jack Elias
Cancer Res December 15 2014 DOI: 10.1158/0008-5472.CAN-13-3339
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Cancer Research Online ISSN: 1538-7445
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