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Research Article

A single-step, high-dose selection scheme reveals distinct mechanisms of acquired resistance to oncogenic kinase inhibition in cancer cells

Kenneth J Finn, Scott E Martin and Jeff Settleman
Kenneth J Finn
Calico Life Sciences, LLC
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Scott E Martin
Discovery Oncology, Genentech
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Jeff Settleman
Oncology R&D, Pfizer (United States)
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  • For correspondence: jeffrey.settleman@pfizer.com
DOI: 10.1158/0008-5472.CAN-19-0729
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ARTICLE USAGE: October 2019 to December 2019

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Article Information

DOI 
https://doi.org/10.1158/0008-5472.CAN-19-0729
PubMed 
31641034

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received March 4, 2019
  • Revision received September 11, 2019
  • Accepted October 11, 2019
  • Published first October 22, 2019.

Article Versions

  • You are currently viewing a Previous version of this article (October 22, 2019 - 06:33).
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Copyright & Usage 
Copyright ©2019, American Association for Cancer Research.

Author Information

  1. Kenneth J Finn1,
  2. Scott E Martin2, and
  3. Jeff Settleman3,*
  1. 1Calico Life Sciences, LLC
  2. 2Discovery Oncology, Genentech
  3. 3Oncology R&D, Pfizer (United States)
  1. ↵* Corresponding Author:
    Jeff Settleman, Oncology R&D, Pfizer (United States), San Diego, CA, 92121, United States. E-mail: jeffrey.settleman{at}pfizer.com
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Published OnlineFirst October 22, 2019
doi: 10.1158/0008-5472.CAN-19-0729

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A single-step, high-dose selection scheme reveals distinct mechanisms of acquired resistance to oncogenic kinase inhibition in cancer cells
Kenneth J Finn, Scott E Martin and Jeff Settleman
Cancer Res October 22 2019 DOI: 10.1158/0008-5472.CAN-19-0729

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A single-step, high-dose selection scheme reveals distinct mechanisms of acquired resistance to oncogenic kinase inhibition in cancer cells
Kenneth J Finn, Scott E Martin and Jeff Settleman
Cancer Res October 22 2019 DOI: 10.1158/0008-5472.CAN-19-0729
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Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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