RT Journal Article
SR Electronic
T1 Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 1859
OP 1872
DO 10.1158/0008-5472.CAN-17-1546
VO 78
IS 7
A1 Walker-Samuel, Simon
A1 Roberts, Thomas A.
A1 Ramasawmy, Rajiv
A1 Burrell, Jake S.
A1 Johnson, Sean Peter
A1 Siow, Bernard M.
A1 Richardson, Simon
A1 Gonçalves, Miguel R.
A1 Pendse, Douglas
A1 Robinson, Simon P.
A1 Pedley, R. Barbara
A1 Lythgoe, Mark F.
YR 2018
UL http://cancerres.aacrjournals.org/content/78/7/1859.abstract
AB Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel MRI technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extravascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations, and tumor xenograft models to investigate the technical feasibility of convection-MRI. We observed a significant correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive measurements of interstitial fluid pressure in mouse models of human colorectal carcinoma. Our results show how convection-MRI can provide insights into the growth and responsiveness to vascular-targeting therapy in colorectal cancers.Significance: A noninvasive method for measuring low-velocity fluid flow caused by raised fluid pressure can be used to assess changes caused by therapy. Cancer Res; 78(7); 1859–72. ©2018 AACR.