RT Journal Article
SR Electronic
T1 Vascular Changes in Cancer Treatment—Seeing Is Believing
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 3461
OP 3462
DO 10.1158/0008-5472.CAN-20-2361
VO 80
IS 17
A1 Tomaszewski, Michal R.
YR 2020
UL http://cancerres.aacrjournals.org/content/80/17/3461.abstract
AB Understanding the effects of novel cancer drugs on the tumor microenvironment will be crucial for their successful use in patients. In this issue of Cancer Research, Ghosh and colleagues discuss the effect of two promising heme-targeting agents on the vascular network in mouse models of lung cancer, utilizing emerging optoacoustic imaging approaches. The findings demonstrating significant, dynamic modulation of tumor hypoxia with the heme-targeting drug treatments create important opportunities for image-guided combination therapy.See related article by Ghosh et al., p. 3542