RT Journal Article
SR Electronic
T1 Deciphering the Complexity of MEK Mutations in the Clinic
JF Cancer Research
JO Cancer Res
FD American Association for Cancer Research
SP 4042
OP 4043
DO 10.1158/0008-5472.CAN-20-2611
VO 80
IS 19
A1 Whitehead, Christopher E.
A1 Sebolt-Leopold, Judith S.
YR 2020
UL http://cancerres.aacrjournals.org/content/80/19/4042.abstract
AB Significant advances in tumor sequencing have led to an explosion in our knowledge of the genetic complexity of cancer. For many cancers, the selection of a targetable alteration is not readily apparent, especially when confronted with mutational variants of unknown significance. The complex clinical landscape of MEK mutations illustrates the need for improved methods to identify those patients, independent of tumor histology, who would benefit from treatment with a MAP kinase pathway inhibitor. In this issue of Cancer Research, Hanrahan and colleagues adopt an in silico platform to attempt to distinguish benign MEK mutations from those that are functional and, therefore, most likely to be therapeutically actionable.See related article by Hanrahan et al., p. 4233