PT  - JOURNAL ARTICLE
AU  - Her, Joonyoung
AU  - Bunting, Samuel F.
TI  - BRCA1 and PALB2 in a Messy Breakup
AID  - 10.1158/0008-5472.CAN-20-2731
DP  - 2020 Oct 01
TA  - Cancer Research
PG  - 4044--4045
VI  - 80
IP  - 19
4099  - http://cancerres.aacrjournals.org/content/80/19/4044.short
4100  - http://cancerres.aacrjournals.org/content/80/19/4044.full
SO  - Cancer Res2020 Oct 01; 80
AB  - Mutations in the BRCA1 gene cause an extremely high lifetime risk of breast and ovarian cancer, but the exact mechanism by which the BRCA1 protein acts to prevent cancer onset remains unclear. In this edition of Cancer Research, Park and colleagues describe a new mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA1. This change prevents BRCA1 from interacting with PALB2 (partner and localizer of BRCA2), causing rapid cancer onset and a loss of blood cells similar to Fanconi anemia.See related article by Park et al., p. 4172